| Round 1 |
| Saturday, 15 September 2018 |
| Aldwinians 3rd XV | 61 | 14 | Marple 2nd XV |
| Altrincham Kersal 3rd XV | v | Bye |
| Ashton-Under-Lyne 2nd XV | v | Bye |
| Aspull 2nd XV | 43 | 24 | Fylde Vandals (4th XV) |
| Blackburn 3rd XV | 15 | 19 | Leigh 3rd XV |
| Bolton 3rd XV | v | Bye |
| Bowdon 3rd XV | v | Bye |
| Broughton Park 3rd XV | 7 | 45 | Dukinfield 2nd XV |
| Clitheroe 2nd XV | 50 | 12 | Rochdale 3rd XV |
| Congleton 2nd XV | 24 | 24 | Oswestry 2nd XV |
| Crewe & Nantwich 3rd XV | v | Bye |
| Firwood Waterloo 3rd XV | 17 | 8 | Southport 3rd XV |
| Hawcoat Park 'A' Team (2nd XV) | 69 | 7 | Burnley 2nd XV |
| Hope Valley | v | Bye |
| Hoylake 2nd XV | 19 | 45 | Birkenhead Park 3rd XV |
| Linley & Kidsgrove 2nd XV | v | Bye |
| Liverpool Collegiate 3rd XV | 12 | 45 | St Edward's O.B. |
| Liverpool St Helens 3rd XV | v | Bye |
| Macclesfield 4th XV | 14 | 55 | Newcastle (Staffs) 2nd XV |
| Manchester 3rd XV | v | Bye |
| Northwich 3rd XV | 26 | 38 | Leek 2nds |
| Ormskirk 2nd XV | 19 | 24 | Merseyside Police |
| Preston Grasshoppers 4th XV | v | Bye |
| Rochdale 4th XV | 7 | 39 | Ashton-on-Mersey |
| Sandbach 3rd XV | v | Bye |
| Sefton 3rd XV | 15 | 45 | Widnes 3rd XV |
| Stockport 3rd XV | 35 | 20 | Burnage 3rd XV |
| Thornton Cleveleys 2nd XV | v | Bye |
| Vale of Lune 4th XV | v | Bye |
| West Park (St Helens) 3rd XV | 59 | 7 | Wallasey |
| Wilmslow 3rd XV | v | Bye |
| Winnington Park 3rd XV | v | Bye |
| Round 2 |
| Saturday, 6 October 2018 |
| Altrincham Kersal 3rd XV | 19 | 55 | Aldwinians 3rd XV |
| Ashton-Under-Lyne 2nd XV | 28 | 13 | Stockport 3rd XV |
| Aspull 2nd XV | 59 | 13 | Ashton-on-Mersey |
| Bolton 3rd XV | 0 | 36 | Hawcoat Park 'A' Team (2nd XV) |
| Bowdon 3rd XV | Home Walkover | Birkenhead Park 3rd XV |
| Crewe & Nantwich 3rd XV | 34 | 31 | Newcastle (Staffs) 2nd XV |
| Hope Valley | 61 | 14 | Widnes 3rd XV |
| Linley & Kidsgrove 2nd XV | 17 | 38 | Leek 2nds |
| Liverpool St Helens 3rd XV | 5 | 27 | St Edward's O.B. |
| Manchester 3rd XV | Away Walkover | West Park (St Helens) 3rd XV |
| Preston Grasshoppers 4th XV | 34 | 13 | Oswestry 2nd XV |
| Sandbach 3rd XV | 39 | 17 | Merseyside Police |
| Thornton Cleveleys 2nd XV | 24 | 25 | Clitheroe 2nd XV |
| Vale of Lune 4th XV | Away Walkover | Leigh 3rd XV |
| Wilmslow 3rd XV | Away Walkover | Dukinfield 2nd XV |
| Winnington Park 3rd XV | Home Walkover | Firwood Waterloo 3rd XV |
| Round 3 |
| Saturday, 1 December 2018 |
| Aldwinians 3rd XV | Home Walkover | Crewe & Nantwich 3rd XV |
| Clitheroe 2nd XV | 47 | 12 | Ashton-Under-Lyne 2nd XV |
| Hawcoat Park 'A' Team (2nd XV) | Home Walkover | Bowdon 3rd XV |
| Hope Valley | 26 | 24 | Dukinfield 2nd XV |
| Leek 2nds | 14 | 5 | Aspull 2nd XV |
| Leigh 3rd XV | 22 | 19 | West Park (St Helens) 3rd XV |
| Preston Grasshoppers 4th XV | Home Walkover | Winnington Park 3rd XV |
| Sandbach 3rd XV | 29 | 27 | St Edward's O.B. |
| Round 4 |
| Saturday, 23 February 2019 |
| Aldwinians 3rd XV | 12 | 56 | Sandbach 3rd XV |
| Clitheroe 2nd XV | 21 | 30 | Leigh 3rd XV |
| Hope Valley | 17 | 19 | Leek 2nds |
| Preston Grasshoppers 4th XV | 25 | 22 | Hawcoat Park 'A' Team (2nd XV) |
| Round 5 |
| Saturday, 16 March 2019 |
| Preston Grasshoppers 4th XV | 10 | 17 | Leek 2nds |
| Sandbach 3rd XV | 23 | 17 | Leigh 3rd XV |
| Round 6 |
| Saturday, 4 May 2019 |
| Sandbach 3rd XV | 7 | 16 | Leek 2nds |