| Saturday, 5 September 2026 |
| Lymm 2nd XV | v | Macclesfield 2nd XV |
| Preston Grasshoppers 2nd XV | v | Caldy 2nd XV |
| Sale FC Vikings 2nd XV | v | Sandbach 2nd XV |
| Stockport 2nd XV | v | Chester 2nd XV |
| Wirral 2nd XV | v | Sedgley Park 2nd XV |
| Saturday, 12 September 2026 |
| Macclesfield 2nd XV | v | Caldy 2nd XV |
| Preston Grasshoppers 2nd XV | v | Fylde Hawks (2nd XV) |
| Sandbach 2nd XV | v | Stockport 2nd XV |
| Sedgley Park 2nd XV | v | Chester 2nd XV |
| Saturday, 19 September 2026 |
| Chester 2nd XV | v | Sandbach 2nd XV |
| Fylde Hawks (2nd XV) | v | Macclesfield 2nd XV |
| Lymm 2nd XV | v | Wirral 2nd XV |
| Sale FC Vikings 2nd XV | v | Preston Grasshoppers 2nd XV |
| Saturday, 26 September 2026 |
| Macclesfield 2nd XV | v | Sale FC Vikings 2nd XV |
| Preston Grasshoppers 2nd XV | v | Stockport 2nd XV |
| Sedgley Park 2nd XV | v | Sandbach 2nd XV |
| Wirral 2nd XV | v | Caldy 2nd XV |
| Saturday, 3 October 2026 |
| Chester 2nd XV | v | Preston Grasshoppers 2nd XV |
| Fylde Hawks (2nd XV) | v | Wirral 2nd XV |
| Lymm 2nd XV | v | Sedgley Park 2nd XV |
| Stockport 2nd XV | v | Macclesfield 2nd XV |
| Saturday, 10 October 2026 |
| Lymm 2nd XV | v | Caldy 2nd XV |
| Macclesfield 2nd XV | v | Chester 2nd XV |
| Preston Grasshoppers 2nd XV | v | Sandbach 2nd XV |
| Wirral 2nd XV | v | Sale FC Vikings 2nd XV |
| Saturday, 17 October 2026 |
| Caldy 2nd XV | v | Sedgley Park 2nd XV |
| Fylde Hawks (2nd XV) | v | Lymm 2nd XV |
| Sandbach 2nd XV | v | Macclesfield 2nd XV |
| Wirral 2nd XV | v | Stockport 2nd XV |
| Saturday, 24 October 2026 |
| Caldy 2nd XV | v | Fylde Hawks (2nd XV) |
| Lymm 2nd XV | v | Sale FC Vikings 2nd XV |
| Sedgley Park 2nd XV | v | Preston Grasshoppers 2nd XV |
| Wirral 2nd XV | v | Chester 2nd XV |
| Saturday, 31 October 2026 |
| Preston Grasshoppers 2nd XV | v | Macclesfield 2nd XV |
| Sale FC Vikings 2nd XV | v | Caldy 2nd XV |
| Sandbach 2nd XV | v | Wirral 2nd XV |
| Sedgley Park 2nd XV | v | Fylde Hawks (2nd XV) |
| Stockport 2nd XV | v | Lymm 2nd XV |
| Saturday, 7 November 2026 |
| Caldy 2nd XV | v | Stockport 2nd XV |
| Fylde Hawks (2nd XV) | v | Sale FC Vikings 2nd XV |
| Lymm 2nd XV | v | Chester 2nd XV |
| Sedgley Park 2nd XV | v | Macclesfield 2nd XV |
| Saturday, 21 November 2026 |
| Chester 2nd XV | v | Caldy 2nd XV |
| Preston Grasshoppers 2nd XV | v | Wirral 2nd XV |
| Sale FC Vikings 2nd XV | v | Sedgley Park 2nd XV |
| Sandbach 2nd XV | v | Lymm 2nd XV |
| Stockport 2nd XV | v | Fylde Hawks (2nd XV) |
| Saturday, 28 November 2026 |
| Caldy 2nd XV | v | Sandbach 2nd XV |
| Fylde Hawks (2nd XV) | v | Chester 2nd XV |
| Sale FC Vikings 2nd XV | v | Stockport 2nd XV |
| Wirral 2nd XV | v | Macclesfield 2nd XV |
| Saturday, 5 December 2026 |
| Chester 2nd XV | v | Sale FC Vikings 2nd XV |
| Preston Grasshoppers 2nd XV | v | Lymm 2nd XV |
| Sandbach 2nd XV | v | Fylde Hawks (2nd XV) |
| Stockport 2nd XV | v | Sedgley Park 2nd XV |
| Saturday, 12 December 2026 |
| Caldy 2nd XV | v | Macclesfield 2nd XV |
| Chester 2nd XV | v | Sedgley Park 2nd XV |
| Stockport 2nd XV | v | Sandbach 2nd XV |
| Saturday, 19 December 2026 |
| Fylde Hawks (2nd XV) | v | Preston Grasshoppers 2nd XV |
| Saturday, 9 January 2027 |
| Macclesfield 2nd XV | v | Fylde Hawks (2nd XV) |
| Preston Grasshoppers 2nd XV | v | Sale FC Vikings 2nd XV |
| Sandbach 2nd XV | v | Chester 2nd XV |
| Wirral 2nd XV | v | Lymm 2nd XV |
| Saturday, 16 January 2027 |
| Caldy 2nd XV | v | Wirral 2nd XV |
| Sale FC Vikings 2nd XV | v | Macclesfield 2nd XV |
| Sandbach 2nd XV | v | Sedgley Park 2nd XV |
| Stockport 2nd XV | v | Preston Grasshoppers 2nd XV |
| Saturday, 23 January 2027 |
| Macclesfield 2nd XV | v | Stockport 2nd XV |
| Preston Grasshoppers 2nd XV | v | Chester 2nd XV |
| Sedgley Park 2nd XV | v | Lymm 2nd XV |
| Wirral 2nd XV | v | Fylde Hawks (2nd XV) |
| Saturday, 6 February 2027 |
| Caldy 2nd XV | v | Lymm 2nd XV |
| Chester 2nd XV | v | Macclesfield 2nd XV |
| Sale FC Vikings 2nd XV | v | Wirral 2nd XV |
| Sandbach 2nd XV | v | Preston Grasshoppers 2nd XV |
| Saturday, 13 February 2027 |
| Lymm 2nd XV | v | Fylde Hawks (2nd XV) |
| Macclesfield 2nd XV | v | Sandbach 2nd XV |
| Sedgley Park 2nd XV | v | Caldy 2nd XV |
| Stockport 2nd XV | v | Wirral 2nd XV |
| Saturday, 20 February 2027 |
| Chester 2nd XV | v | Wirral 2nd XV |
| Fylde Hawks (2nd XV) | v | Caldy 2nd XV |
| Preston Grasshoppers 2nd XV | v | Sedgley Park 2nd XV |
| Sale FC Vikings 2nd XV | v | Lymm 2nd XV |
| Saturday, 27 February 2027 |
| Caldy 2nd XV | v | Sale FC Vikings 2nd XV |
| Fylde Hawks (2nd XV) | v | Sedgley Park 2nd XV |
| Lymm 2nd XV | v | Stockport 2nd XV |
| Macclesfield 2nd XV | v | Preston Grasshoppers 2nd XV |
| Wirral 2nd XV | v | Sandbach 2nd XV |
| Saturday, 13 March 2027 |
| Chester 2nd XV | v | Lymm 2nd XV |
| Macclesfield 2nd XV | v | Sedgley Park 2nd XV |
| Sale FC Vikings 2nd XV | v | Fylde Hawks (2nd XV) |
| Stockport 2nd XV | v | Caldy 2nd XV |
| Saturday, 20 March 2027 |
| Caldy 2nd XV | v | Chester 2nd XV |
| Fylde Hawks (2nd XV) | v | Stockport 2nd XV |
| Lymm 2nd XV | v | Sandbach 2nd XV |
| Sedgley Park 2nd XV | v | Sale FC Vikings 2nd XV |
| Wirral 2nd XV | v | Preston Grasshoppers 2nd XV |
| Saturday, 3 April 2027 |
| Chester 2nd XV | v | Fylde Hawks (2nd XV) |
| Macclesfield 2nd XV | v | Wirral 2nd XV |
| Sandbach 2nd XV | v | Caldy 2nd XV |
| Stockport 2nd XV | v | Sale FC Vikings 2nd XV |
| Saturday, 10 April 2027 |
| Fylde Hawks (2nd XV) | v | Sandbach 2nd XV |
| Lymm 2nd XV | v | Preston Grasshoppers 2nd XV |
| Sale FC Vikings 2nd XV | v | Chester 2nd XV |
| Sedgley Park 2nd XV | v | Stockport 2nd XV |
| Saturday, 17 April 2027 |
| Caldy 2nd XV | v | Preston Grasshoppers 2nd XV |
| Chester 2nd XV | v | Stockport 2nd XV |
| Macclesfield 2nd XV | v | Lymm 2nd XV |
| Sandbach 2nd XV | v | Sale FC Vikings 2nd XV |
| Sedgley Park 2nd XV | v | Wirral 2nd XV |