| Saturday, 12 September 2026 |
| Bolton 2nd XV | v | Blackpool |
| De La Salle (Salford) | v | Trafford MV 2nd XV |
| Fleetwood Wyresiders (2nd XV) | v | North Manchester |
| Leigh 2nd XV | v | Blackburn RUFC Vikings |
| Vale of Lune 3rd XV | v | Bury 2nd XV |
| Saturday, 19 September 2026 |
| Blackburn RUFC Vikings | v | Rossendale 2nd XV |
| Blackpool | v | Fleetwood Wyresiders (2nd XV) |
| North Manchester | v | Leigh 2nd XV |
| Trafford MV 2nd XV | v | Bolton 2nd XV |
| Vale of Lune 3rd XV | v | De La Salle (Salford) |
| Saturday, 26 September 2026 |
| Bolton 2nd XV | v | Vale of Lune 3rd XV |
| De La Salle (Salford) | v | Bury 2nd XV |
| Fleetwood Wyresiders (2nd XV) | v | Trafford MV 2nd XV |
| Leigh 2nd XV | v | Blackpool |
| Rossendale 2nd XV | v | North Manchester |
| Saturday, 3 October 2026 |
| Blackpool | v | Rossendale 2nd XV |
| Bury 2nd XV | v | Blackburn RUFC Vikings |
| De La Salle (Salford) | v | Bolton 2nd XV |
| Trafford MV 2nd XV | v | Leigh 2nd XV |
| Vale of Lune 3rd XV | v | Fleetwood Wyresiders (2nd XV) |
| Saturday, 17 October 2026 |
| Blackburn RUFC Vikings | v | North Manchester |
| Bolton 2nd XV | v | Bury 2nd XV |
| Fleetwood Wyresiders (2nd XV) | v | De La Salle (Salford) |
| Leigh 2nd XV | v | Vale of Lune 3rd XV |
| Rossendale 2nd XV | v | Trafford MV 2nd XV |
| Saturday, 24 October 2026 |
| Blackpool | v | Blackburn RUFC Vikings |
| Bolton 2nd XV | v | Fleetwood Wyresiders (2nd XV) |
| Bury 2nd XV | v | North Manchester |
| De La Salle (Salford) | v | Leigh 2nd XV |
| Vale of Lune 3rd XV | v | Rossendale 2nd XV |
| Saturday, 31 October 2026 |
| Blackburn RUFC Vikings | v | Trafford MV 2nd XV |
| Fleetwood Wyresiders (2nd XV) | v | Bury 2nd XV |
| Leigh 2nd XV | v | Bolton 2nd XV |
| North Manchester | v | Blackpool |
| Rossendale 2nd XV | v | De La Salle (Salford) |
| Saturday, 7 November 2026 |
| Bolton 2nd XV | v | Rossendale 2nd XV |
| Bury 2nd XV | v | Blackpool |
| Fleetwood Wyresiders (2nd XV) | v | Leigh 2nd XV |
| North Manchester | v | Trafford MV 2nd XV |
| Vale of Lune 3rd XV | v | Blackburn RUFC Vikings |
| Saturday, 28 November 2026 |
| Bolton 2nd XV | v | Blackburn RUFC Vikings |
| Bury 2nd XV | v | Trafford MV 2nd XV |
| De La Salle (Salford) | v | North Manchester |
| Leigh 2nd XV | v | Rossendale 2nd XV |
| Vale of Lune 3rd XV | v | Blackpool |
| Saturday, 5 December 2026 |
| Blackburn RUFC Vikings | v | Fleetwood Wyresiders (2nd XV) |
| Blackpool | v | De La Salle (Salford) |
| North Manchester | v | Bolton 2nd XV |
| Rossendale 2nd XV | v | Bury 2nd XV |
| Trafford MV 2nd XV | v | Vale of Lune 3rd XV |
| Saturday, 12 December 2026 |
| Bolton 2nd XV | v | Trafford MV 2nd XV |
| De La Salle (Salford) | v | Vale of Lune 3rd XV |
| Fleetwood Wyresiders (2nd XV) | v | Blackpool |
| Leigh 2nd XV | v | North Manchester |
| Rossendale 2nd XV | v | Blackburn RUFC Vikings |
| Saturday, 16 January 2027 |
| Blackburn RUFC Vikings | v | Bury 2nd XV |
| Bolton 2nd XV | v | De La Salle (Salford) |
| Fleetwood Wyresiders (2nd XV) | v | Vale of Lune 3rd XV |
| Leigh 2nd XV | v | Trafford MV 2nd XV |
| Rossendale 2nd XV | v | Blackpool |
| Saturday, 23 January 2027 |
| Bury 2nd XV | v | Bolton 2nd XV |
| De La Salle (Salford) | v | Fleetwood Wyresiders (2nd XV) |
| North Manchester | v | Blackburn RUFC Vikings |
| Trafford MV 2nd XV | v | Rossendale 2nd XV |
| Vale of Lune 3rd XV | v | Leigh 2nd XV |
| Saturday, 6 February 2027 |
| Blackburn RUFC Vikings | v | Blackpool |
| Fleetwood Wyresiders (2nd XV) | v | Bolton 2nd XV |
| Leigh 2nd XV | v | De La Salle (Salford) |
| North Manchester | v | Bury 2nd XV |
| Rossendale 2nd XV | v | Vale of Lune 3rd XV |
| Saturday, 13 February 2027 |
| Blackpool | v | North Manchester |
| Bolton 2nd XV | v | Leigh 2nd XV |
| Bury 2nd XV | v | Fleetwood Wyresiders (2nd XV) |
| De La Salle (Salford) | v | Rossendale 2nd XV |
| Trafford MV 2nd XV | v | Blackburn RUFC Vikings |
| Saturday, 20 February 2027 |
| Blackburn RUFC Vikings | v | Vale of Lune 3rd XV |
| Blackpool | v | Bury 2nd XV |
| Leigh 2nd XV | v | Fleetwood Wyresiders (2nd XV) |
| Rossendale 2nd XV | v | Bolton 2nd XV |
| Trafford MV 2nd XV | v | North Manchester |
| Saturday, 27 February 2027 |
| Blackpool | v | Leigh 2nd XV |
| Bury 2nd XV | v | De La Salle (Salford) |
| North Manchester | v | Rossendale 2nd XV |
| Trafford MV 2nd XV | v | Fleetwood Wyresiders (2nd XV) |
| Vale of Lune 3rd XV | v | Bolton 2nd XV |
| Saturday, 6 March 2027 |
| Bury 2nd XV | v | Leigh 2nd XV |
| De La Salle (Salford) | v | Blackburn RUFC Vikings |
| Fleetwood Wyresiders (2nd XV) | v | Rossendale 2nd XV |
| Trafford MV 2nd XV | v | Blackpool |
| Vale of Lune 3rd XV | v | North Manchester |
| Saturday, 13 March 2027 |
| Blackburn RUFC Vikings | v | Bolton 2nd XV |
| Blackpool | v | Vale of Lune 3rd XV |
| North Manchester | v | De La Salle (Salford) |
| Rossendale 2nd XV | v | Leigh 2nd XV |
| Trafford MV 2nd XV | v | Bury 2nd XV |
| Saturday, 3 April 2027 |
| Bolton 2nd XV | v | North Manchester |
| Bury 2nd XV | v | Rossendale 2nd XV |
| De La Salle (Salford) | v | Blackpool |
| Fleetwood Wyresiders (2nd XV) | v | Blackburn RUFC Vikings |
| Vale of Lune 3rd XV | v | Trafford MV 2nd XV |
| Saturday, 10 April 2027 |
| Blackburn RUFC Vikings | v | Leigh 2nd XV |
| Blackpool | v | Bolton 2nd XV |
| Bury 2nd XV | v | Vale of Lune 3rd XV |
| North Manchester | v | Fleetwood Wyresiders (2nd XV) |
| Trafford MV 2nd XV | v | De La Salle (Salford) |
| Saturday, 17 April 2027 |
| Blackburn RUFC Vikings | v | De La Salle (Salford) |
| Blackpool | v | Trafford MV 2nd XV |
| Leigh 2nd XV | v | Bury 2nd XV |
| North Manchester | v | Vale of Lune 3rd XV |
| Rossendale 2nd XV | v | Fleetwood Wyresiders (2nd XV) |