| Round 1 |
| Saturday, 12 October 2024 |
| 1 | Warrington 2nd XV | v | Bye |
| 2 | Blackburn 3rd XV | 32 | 17 | Orrell 2nd XV |
| 3 | Bolton 2nd XV | Home Walkover | Colne & Nelson 2nd XV |
| 4 | Garstang Blues (2nd XV) | 41 | 5 | Fleetwood Wyresiders (2nd XV) |
| 5 | Clitheroe 2nd XV | Home Walkover | Vale of Lune 3rd XV |
| 6 | Preston Grasshoppers 5th XV | Home Walkover | Thornton Cleveleys 2nd XV |
| 7 | Glossop 2nd XV | v | Bye |
| 8 | Altrincham Kersal Cougars (2nd XV) | v | Bye |
| 9 | Rossendale 3rd XV | v | Bye |
| 10 | Eccles 3rd XV | v | Bye |
| 11 | Fylde Vandals (4th XV) | Home Walkover | Ormskirk 2nd XV |
| 12 | North Manchester | v | Bye |
| 13 | Wigan 2nd XV | v | Bye |
| 14 | Rochdale 3rd XV | 24 | 57 | Tyldesley 2nd XV |
| 15 | Leigh 2nd XV | 17 | 43 | Trafford MV 2nd XV |
| 16 | Aldwinians 3rd XV | v | Bye |
| Round 2 |
| Saturday, 2 November 2024 |
| Warrington 2nd XV | 14 | 12 | Blackburn 3rd XV |
| Bolton 2nd XV | 27 | 19 | Garstang Blues (2nd XV) |
| Clitheroe 2nd XV | Home Walkover | Preston Grasshoppers 5th XV |
| Rossendale 3rd XV | 17 | 28 | Eccles 3rd XV |
| Fylde Vandals (4th XV) | 81 | 0 | North Manchester |
| Wigan 2nd XV | 54 | 5 | Tyldesley 2nd XV |
| Trafford MV 2nd XV | 41 | 5 | Aldwinians 3rd XV |
| Saturday, 14 December 2024 |
| Glossop 2nd XV | 40 | 17 | Altrincham Kersal Cougars (2nd XV) |
| Round 3 |
| Saturday, 18 January 2025 |
| Bolton 2nd XV | 21 | 30 | Fylde Vandals (4th XV) |
| Saturday, 25 January 2025 |
| Warrington 2nd XV | Home Walkover | Glossop 2nd XV |
| Clitheroe 2nd XV | 6 | 77 | Wigan 2nd XV |
| Eccles 3rd XV | 17 | 19 | Trafford MV 2nd XV |
| Round 4 |
| Saturday, 29 March 2025 |
| Warrington 2nd XV | 24 | 25 | Wigan 2nd XV |
| Trafford MV 2nd XV | 29 | 25 | Fylde Vandals (4th XV) |
| Round 5 |
| Saturday, 3 May 2025 |
| Wigan 2nd XV | 27 | 25 | Trafford MV 2nd XV |