| Round 1 |
| Saturday, 12 October 2024 |
| 1 | Buxton RUFC | 6 | 48 | Winnington Park 2nd XV |
| 2 | Macclesfield 3rd XV | v | Bye |
| 3 | Lymm Eagles | v | Bye |
| 4 | Wallasey | v | Bye |
| 5 | Port Sunlight | 22 | 19 | Oldershaw |
| 6 | Caldy 3rd XV | 35 | 7 | Wirral 3rd XV |
| 7 | Knutsford | 33 | 54 | Moore |
| 8 | Capenhurst | v | Bye |
| 9 | Crosby St Mary's | 19 | 19 | Newton-le-Willows |
| 10 | Wilmslow 2nd XV | v | Bye |
| 11 | Liverpool Medical School | v | Bye |
| 12 | Ruskin Park | v | Bye |
| 13 | Birchfield | 29 | 14 | Oxton Parkonians |
| 14 | Manchester Medical School 1st XV | v | Bye |
| 15 | Marple | v | Bye |
| 16 | Stockport 3rd XV | 43 | 0 | Liverpool University Veterinarians |
| Round 2 |
| Saturday, 2 November 2024 |
| Winnington Park 2nd XV | Home Walkover | Macclesfield 3rd XV |
| Lymm Eagles | 46 | 24 | Wallasey |
| Moore | Home Walkover | Capenhurst |
| Newton-le-Willows | Home Walkover | Wilmslow 2nd XV |
| Liverpool Medical School | 12 | 0 | Ruskin Park |
| Birchfield | Home Walkover | Manchester Medical School 1st XV |
| Marple | 18 | 17 | Stockport 3rd XV |
| Saturday, 14 December 2024 |
| Port Sunlight | 14 | 57 | Caldy 3rd XV |
| Round 3 |
| Saturday, 25 January 2025 |
| Winnington Park 2nd XV | 46 | 12 | Moore |
| Caldy 3rd XV | Home Walkover | Birchfield |
| Newton-le-Willows | 28 | 29 | Marple |
| Liverpool Medical School | Away Walkover | Lymm Eagles |
| Round 4 |
| Saturday, 29 March 2025 |
| Winnington Park 2nd XV | 28 | 28 | Caldy 3rd XV |
| Marple | 37 | 12 | Lymm Eagles |
| Round 5 |
| Saturday, 3 May 2025 |
| Caldy 3rd XV | 15 | 46 | Marple |