| Saturday, 7 September 2024 |
| Southport 2nd XV | 31 | 35 | Blackpool |
| Tarleton 2nd XV | 19 | 33 | Widnes 2nd XV |
| Saturday, 14 September 2024 |
| Blackpool | Home Walkover | Liverpool St Helens 2nd XV |
| Sedgley Park 3rd XV | 21 | 7 | Southport 2nd XV |
| West Park (St Helens) 2nd XV | 55 | 27 | Tarleton 2nd XV |
| Saturday, 21 September 2024 |
| Liverpool St Helens 2nd XV | 29 | 0 | Sedgley Park 3rd XV |
| Tarleton 2nd XV | 14 | 24 | Littleborough 2nd XV |
| Widnes 2nd XV | 22 | 21 | West Park (St Helens) 2nd XV |
| Saturday, 28 September 2024 |
| Aspull Development XV | 7 | 41 | Tarleton 2nd XV |
| Littleborough 2nd XV | 22 | 19 | Widnes 2nd XV |
| Liverpool St Helens 2nd XV | 36 | 26 | Southport 2nd XV |
| Saturday, 5 October 2024 |
| Aspull Development XV | 5 | 33 | Sedgley Park 3rd XV |
| Blackpool | Home Walkover | Kirkby Lonsdale RUFC Development XV |
| Littleborough 2nd XV | 19 | 34 | Southport 2nd XV |
| West Park (St Helens) 2nd XV | 27 | 19 | Liverpool St Helens 2nd XV |
| Saturday, 12 October 2024 |
| Tarleton 2nd XV | 17 | 5 | Kirkby Lonsdale RUFC Development XV |
| West Park (St Helens) 2nd XV | Home Walkover | Littleborough 2nd XV |
| Widnes 2nd XV | Home Walkover | Aspull Development XV |
| Saturday, 19 October 2024 |
| Aspull Development XV | 24 | 24 | West Park (St Helens) 2nd XV |
| Blackpool | 12 | 44 | Tarleton 2nd XV |
| Kirkby Lonsdale RUFC Development XV | 41 | 36 | Widnes 2nd XV |
| Saturday, 26 October 2024 |
| Littleborough 2nd XV | 28 | 45 | Aspull Development XV |
| Tarleton 2nd XV | 40 | 5 | Sedgley Park 3rd XV |
| West Park (St Helens) 2nd XV | 29 | 0 | Kirkby Lonsdale RUFC Development XV |
| Widnes 2nd XV | 71 | 10 | Blackpool |
| Saturday, 9 November 2024 |
| Blackpool | 27 | 21 | West Park (St Helens) 2nd XV |
| Littleborough 2nd XV | 71 | 23 | Kirkby Lonsdale RUFC Development XV |
| Sedgley Park 3rd XV | 17 | 32 | Widnes 2nd XV |
| Tarleton 2nd XV | 8 | 24 | Southport 2nd XV |
| Saturday, 16 November 2024 |
| Aspull Development XV | 34 | 17 | Kirkby Lonsdale RUFC Development XV |
| Littleborough 2nd XV | 34 | 26 | Blackpool |
| Sedgley Park 3rd XV | 26 | 12 | West Park (St Helens) 2nd XV |
| Tarleton 2nd XV | 13 | 19 | Liverpool St Helens 2nd XV |
| Widnes 2nd XV | 38 | 7 | Southport 2nd XV |
| Saturday, 23 November 2024 |
| Blackpool | 30 | 38 | Aspull Development XV |
| Southport 2nd XV | 38 | 5 | West Park (St Helens) 2nd XV |
| Saturday, 30 November 2024 |
| Kirkby Lonsdale RUFC Development XV | Home Walkover | Sedgley Park 3rd XV |
| Liverpool St Helens 2nd XV | 41 | 17 | Littleborough 2nd XV |
| Southport 2nd XV | 10 | 15 | Aspull Development XV |
| Saturday, 7 December 2024 |
| Sedgley Park 3rd XV | 7 | 33 | Aspull Development XV |
| Saturday, 14 December 2024 |
| Aspull Development XV | 27 | 24 | Southport 2nd XV |
| Kirkby Lonsdale RUFC Development XV | 14 | 21 | Sedgley Park 3rd XV |
| Littleborough 2nd XV | 75 | 10 | Liverpool St Helens 2nd XV |
| Saturday, 21 December 2024 |
| Aspull Development XV | 20 | 12 | Liverpool St Helens 2nd XV |
| Kirkby Lonsdale RUFC Development XV | Home Walkover | Southport 2nd XV |
| Saturday, 4 January 2025 |
| Liverpool St Helens 2nd XV | Home Walkover | Kirkby Lonsdale RUFC Development XV |
| Saturday, 18 January 2025 |
| Southport 2nd XV | 19 | 14 | Liverpool St Helens 2nd XV |
| Tarleton 2nd XV | 22 | 26 | Aspull Development XV |
| Widnes 2nd XV | 36 | 12 | Littleborough 2nd XV |
| Saturday, 25 January 2025 |
| Liverpool St Helens 2nd XV | 0 | 58 | West Park (St Helens) 2nd XV |
| Sedgley Park 3rd XV | 24 | 27 | Littleborough 2nd XV |
| Saturday, 1 February 2025 |
| Kirkby Lonsdale RUFC Development XV | 19 | 29 | Tarleton 2nd XV |
| Sedgley Park 3rd XV | 45 | 0 | Liverpool St Helens 2nd XV |
| West Park (St Helens) 2nd XV | 43 | 10 | Littleborough 2nd XV |
| Widnes 2nd XV | 34 | 12 | Aspull Development XV |
| Saturday, 8 February 2025 |
| Kirkby Lonsdale RUFC Development XV | 20 | 17 | Southport 2nd XV |
| Liverpool St Helens 2nd XV | 10 | 64 | Aspull Development XV |
| Saturday, 15 February 2025 |
| Southport 2nd XV | 15 | 12 | Littleborough 2nd XV |
| Tarleton 2nd XV | 41 | 13 | Blackpool |
| West Park (St Helens) 2nd XV | 28 | 45 | Aspull Development XV |
| Widnes 2nd XV | Home Walkover | Kirkby Lonsdale RUFC Development XV |
| Saturday, 22 February 2025 |
| Blackpool | 5 | 5 | Southport 2nd XV |
| Liverpool St Helens 2nd XV | 38 | 14 | Kirkby Lonsdale RUFC Development XV |
| Widnes 2nd XV | 45 | 12 | Tarleton 2nd XV |
| Saturday, 1 March 2025 |
| Aspull Development XV | 33 | 28 | Littleborough 2nd XV |
| Blackpool | 5 | 38 | Widnes 2nd XV |
| Kirkby Lonsdale RUFC Development XV | 35 | 38 | West Park (St Helens) 2nd XV |
| Sedgley Park 3rd XV | 21 | 59 | Tarleton 2nd XV |
| Saturday, 8 March 2025 |
| Kirkby Lonsdale RUFC Development XV | 48 | 7 | Littleborough 2nd XV |
| Southport 2nd XV | 10 | 17 | Tarleton 2nd XV |
| West Park (St Helens) 2nd XV | Home Walkover | Blackpool |
| Widnes 2nd XV | Home Walkover | Sedgley Park 3rd XV |
| Saturday, 15 March 2025 |
| Blackpool | 31 | 47 | Kirkby Lonsdale RUFC Development XV |
| Liverpool St Helens 2nd XV | 5 | 21 | Widnes 2nd XV |
| Saturday, 22 March 2025 |
| Blackpool | Away Walkover | Littleborough 2nd XV |
| Kirkby Lonsdale RUFC Development XV | 33 | 24 | Aspull Development XV |
| Liverpool St Helens 2nd XV | 5 | 38 | Tarleton 2nd XV |
| Southport 2nd XV | 12 | 42 | Widnes 2nd XV |
| West Park (St Helens) 2nd XV | 33 | 19 | Sedgley Park 3rd XV |
| Saturday, 29 March 2025 |
| Blackpool | 24 | 7 | Sedgley Park 3rd XV |
| Saturday, 5 April 2025 |
| Aspull Development XV | Home Walkover | Blackpool |
| Littleborough 2nd XV | 47 | 24 | Sedgley Park 3rd XV |
| West Park (St Helens) 2nd XV | 68 | 10 | Southport 2nd XV |
| Widnes 2nd XV | 33 | 26 | Liverpool St Helens 2nd XV |
| Saturday, 12 April 2025 |
| Littleborough 2nd XV | 33 | 15 | Tarleton 2nd XV |
| Sedgley Park 3rd XV | 51 | 15 | Blackpool |
| West Park (St Helens) 2nd XV | Home Walkover | Widnes 2nd XV |
| Saturday, 26 April 2025 |
| Blackpool | v | Liverpool St Helens 2nd XV |
| Southport 2nd XV | v | Sedgley Park 3rd XV |
| Tarleton 2nd XV | v | West Park (St Helens) 2nd XV |