| Saturday, 7 September 2024 |
| Blackburn 2nd XV | 7 | 64 | Fylde Hawks (2nd XV) |
| Caldy 2nd XV | 62 | 12 | Lymm 2nd XV |
| Macclesfield 2nd XV | 31 | 37 | Preston Grasshoppers 2nd XV |
| Rossendale 2nd XV | 8 | 48 | Chester 2nd XV |
| Sedgley Park 2nd XV | 66 | 14 | Manchester 2nd XV |
| Saturday, 14 September 2024 |
| Chester 2nd XV | 83 | 12 | Blackburn 2nd XV |
| Lymm 2nd XV | 65 | 22 | Macclesfield 2nd XV |
| Manchester 2nd XV | 15 | 52 | Fylde Hawks (2nd XV) |
| Preston Grasshoppers 2nd XV | 86 | 10 | Wirral 2nd XV |
| Sedgley Park 2nd XV | 15 | 52 | Caldy 2nd XV |
| Saturday, 21 September 2024 |
| Caldy 2nd XV | Home Walkover | Manchester 2nd XV |
| Fylde Hawks (2nd XV) | 68 | 19 | Chester 2nd XV |
| Macclesfield 2nd XV | 29 | 26 | Sedgley Park 2nd XV |
| Rossendale 2nd XV | 46 | 26 | Preston Grasshoppers 2nd XV |
| Wirral 2nd XV | 38 | 42 | Lymm 2nd XV |
| Saturday, 28 September 2024 |
| Caldy 2nd XV | 83 | 10 | Macclesfield 2nd XV |
| Manchester 2nd XV | 7 | 67 | Chester 2nd XV |
| Preston Grasshoppers 2nd XV | 38 | 22 | Blackburn 2nd XV |
| Sedgley Park 2nd XV | 53 | 5 | Wirral 2nd XV |
| Saturday, 5 October 2024 |
| Lymm 2nd XV | 44 | 43 | Rossendale 2nd XV |
| Saturday, 12 October 2024 |
| Blackburn 2nd XV | 33 | 15 | Lymm 2nd XV |
| Fylde Hawks (2nd XV) | 47 | 22 | Preston Grasshoppers 2nd XV |
| Macclesfield 2nd XV | 38 | 17 | Manchester 2nd XV |
| Rossendale 2nd XV | 22 | 26 | Sedgley Park 2nd XV |
| Wirral 2nd XV | 0 | 62 | Caldy 2nd XV |
| Saturday, 19 October 2024 |
| Caldy 2nd XV | Home Walkover | Rossendale 2nd XV |
| Lymm 2nd XV | 21 | 38 | Fylde Hawks (2nd XV) |
| Macclesfield 2nd XV | 29 | 46 | Wirral 2nd XV |
| Preston Grasshoppers 2nd XV | 31 | 36 | Chester 2nd XV |
| Sedgley Park 2nd XV | 68 | 21 | Blackburn 2nd XV |
| Saturday, 26 October 2024 |
| Blackburn 2nd XV | Away Walkover | Caldy 2nd XV |
| Chester 2nd XV | 52 | 38 | Lymm 2nd XV |
| Fylde Hawks (2nd XV) | 38 | 12 | Sedgley Park 2nd XV |
| Manchester 2nd XV | 53 | 26 | Wirral 2nd XV |
| Rossendale 2nd XV | 24 | 45 | Macclesfield 2nd XV |
| Saturday, 9 November 2024 |
| Caldy 2nd XV | 52 | 22 | Fylde Hawks (2nd XV) |
| Macclesfield 2nd XV | 81 | 5 | Blackburn 2nd XV |
| Manchester 2nd XV | 33 | 14 | Preston Grasshoppers 2nd XV |
| Rossendale 2nd XV | 29 | 20 | Wirral 2nd XV |
| Sedgley Park 2nd XV | 19 | 59 | Chester 2nd XV |
| Friday, 15 November 2024 |
| Chester 2nd XV | 31 | 64 | Caldy 2nd XV |
| Saturday, 16 November 2024 |
| Blackburn 2nd XV | 21 | 19 | Wirral 2nd XV |
| Fylde Hawks (2nd XV) | Home Walkover | Macclesfield 2nd XV |
| Manchester 2nd XV | 66 | 5 | Rossendale 2nd XV |
| Preston Grasshoppers 2nd XV | 59 | 52 | Lymm 2nd XV |
| Saturday, 23 November 2024 |
| Manchester 2nd XV | 24 | 14 | Lymm 2nd XV |
| Wirral 2nd XV | 22 | 26 | Fylde Hawks (2nd XV) |
| Saturday, 7 December 2024 |
| Blackburn 2nd XV | 0 | 26 | Manchester 2nd XV |
| Chester 2nd XV | 24 | 7 | Wirral 2nd XV |
| Lymm 2nd XV | 20 | 19 | Sedgley Park 2nd XV |
| Saturday, 14 December 2024 |
| Blackburn 2nd XV | 19 | 34 | Chester 2nd XV |
| Caldy 2nd XV | Home Walkover | Sedgley Park 2nd XV |
| Fylde Hawks (2nd XV) | 60 | 7 | Manchester 2nd XV |
| Macclesfield 2nd XV | 29 | 33 | Lymm 2nd XV |
| Wirral 2nd XV | 26 | 57 | Preston Grasshoppers 2nd XV |
| Saturday, 21 December 2024 |
| Caldy 2nd XV | Home Walkover | Manchester 2nd XV |
| Chester 2nd XV | 34 | 45 | Fylde Hawks (2nd XV) |
| Lymm 2nd XV | 41 | 7 | Wirral 2nd XV |
| Preston Grasshoppers 2nd XV | Home Walkover | Rossendale 2nd XV |
| Sedgley Park 2nd XV | 19 | 25 | Macclesfield 2nd XV |
| Saturday, 11 January 2025 |
| Caldy 2nd XV | Home Walkover | Wirral 2nd XV |
| Saturday, 18 January 2025 |
| Blackburn 2nd XV | 5 | 39 | Sedgley Park 2nd XV |
| Caldy 2nd XV | 77 | 19 | Rossendale 2nd XV |
| Chester 2nd XV | 21 | 15 | Preston Grasshoppers 2nd XV |
| Fylde Hawks (2nd XV) | 52 | 26 | Lymm 2nd XV |
| Wirral 2nd XV | 22 | 29 | Macclesfield 2nd XV |
| Saturday, 1 February 2025 |
| Caldy 2nd XV | Home Walkover | Blackburn 2nd XV |
| Lymm 2nd XV | 17 | 40 | Chester 2nd XV |
| Macclesfield 2nd XV | 44 | 14 | Rossendale 2nd XV |
| Sedgley Park 2nd XV | Home Walkover | Fylde Hawks (2nd XV) |
| Wirral 2nd XV | 14 | 56 | Manchester 2nd XV |
| Saturday, 8 February 2025 |
| Macclesfield 2nd XV | 18 | 52 | Chester 2nd XV |
| Preston Grasshoppers 2nd XV | 26 | 41 | Caldy 2nd XV |
| Rossendale 2nd XV | 29 | 29 | Blackburn 2nd XV |
| Saturday, 15 February 2025 |
| Blackburn 2nd XV | 29 | 30 | Macclesfield 2nd XV |
| Fylde Hawks (2nd XV) | 21 | 22 | Caldy 2nd XV |
| Preston Grasshoppers 2nd XV | 75 | 10 | Manchester 2nd XV |
| Wirral 2nd XV | 47 | 36 | Rossendale 2nd XV |
| Saturday, 22 February 2025 |
| Fylde Hawks (2nd XV) | 55 | 25 | Rossendale 2nd XV |
| Saturday, 1 March 2025 |
| Caldy 2nd XV | 50 | 12 | Chester 2nd XV |
| Lymm 2nd XV | 13 | 50 | Preston Grasshoppers 2nd XV |
| Rossendale 2nd XV | 14 | 48 | Manchester 2nd XV |
| Wirral 2nd XV | 33 | 31 | Blackburn 2nd XV |
| Saturday, 8 March 2025 |
| Blackburn 2nd XV | 31 | 34 | Rossendale 2nd XV |
| Chester 2nd XV | 60 | 15 | Macclesfield 2nd XV |
| Fylde Hawks (2nd XV) | Home Walkover | Wirral 2nd XV |
| Lymm 2nd XV | 36 | 15 | Manchester 2nd XV |
| Preston Grasshoppers 2nd XV | 59 | 0 | Sedgley Park 2nd XV |
| Preston Grasshoppers 2nd XV | 59 | 0 | Sedgley Park 2nd XV |
| Friday, 14 March 2025 |
| Preston Grasshoppers 2nd XV | 50 | 19 | Fylde Hawks (2nd XV) |
| Saturday, 15 March 2025 |
| Lymm 2nd XV | 54 | 47 | Blackburn 2nd XV |
| Manchester 2nd XV | 63 | 18 | Macclesfield 2nd XV |
| Sedgley Park 2nd XV | 24 | 31 | Rossendale 2nd XV |
| Saturday, 22 March 2025 |
| Caldy 2nd XV | 38 | 15 | Preston Grasshoppers 2nd XV |
| Manchester 2nd XV | 52 | 10 | Blackburn 2nd XV |
| Rossendale 2nd XV | 28 | 44 | Fylde Hawks (2nd XV) |
| Sedgley Park 2nd XV | Home Walkover | Lymm 2nd XV |
| Wirral 2nd XV | 10 | 26 | Chester 2nd XV |
| Saturday, 29 March 2025 |
| Chester 2nd XV | 19 | 20 | Sedgley Park 2nd XV |
| Fylde Hawks (2nd XV) | 14 | 32 | Macclesfield 2nd XV |
| Saturday, 5 April 2025 |
| Chester 2nd XV | 66 | 21 | Rossendale 2nd XV |
| Fylde Hawks (2nd XV) | 95 | 12 | Blackburn 2nd XV |
| Lymm 2nd XV | Away Walkover | Caldy 2nd XV |
| Manchester 2nd XV | 28 | 17 | Sedgley Park 2nd XV |
| Preston Grasshoppers 2nd XV | 52 | 14 | Macclesfield 2nd XV |
| Saturday, 26 April 2025 |
| Blackburn 2nd XV | v | Preston Grasshoppers 2nd XV |
| Chester 2nd XV | v | Manchester 2nd XV |
| Macclesfield 2nd XV | v | Caldy 2nd XV |
| Rossendale 2nd XV | v | Lymm 2nd XV |
| Wirral 2nd XV | v | Sedgley Park 2nd XV |