| Saturday, 3 September 2022 |
| Blackburn 2nd XV | v | Wirral 2nd XV |
| Burnage 2nd XV | v | Stockport 2nd XV |
| Caldy 2nd XV | v | Rossendale 2nd XV |
| Chester 2nd XV | v | Preston Grasshoppers 2nd XV |
| Lymm 2nd XV | v | Fylde Hawks (2nd XV) |
| Sedgley Park 2nd XV | v | Sandbach 2nd XV |
| Saturday, 10 September 2022 |
| Blackburn 2nd XV | v | Burnage 2nd XV |
| Fylde Hawks (2nd XV) | v | Chester 2nd XV |
| Rossendale 2nd XV | v | Lymm 2nd XV |
| Sandbach 2nd XV | v | Caldy 2nd XV |
| Stockport 2nd XV | v | Sedgley Park 2nd XV |
| Wirral 2nd XV | v | Preston Grasshoppers 2nd XV |
| Saturday, 17 September 2022 |
| Blackburn 2nd XV | v | Sedgley Park 2nd XV |
| Burnage 2nd XV | v | Wirral 2nd XV |
| Caldy 2nd XV | v | Stockport 2nd XV |
| Chester 2nd XV | v | Rossendale 2nd XV |
| Lymm 2nd XV | v | Sandbach 2nd XV |
| Preston Grasshoppers 2nd XV | v | Fylde Hawks (2nd XV) |
| Saturday, 24 September 2022 |
| Blackburn 2nd XV | v | Caldy 2nd XV |
| Burnage 2nd XV | v | Sedgley Park 2nd XV |
| Rossendale 2nd XV | v | Preston Grasshoppers 2nd XV |
| Sandbach 2nd XV | v | Chester 2nd XV |
| Stockport 2nd XV | v | Lymm 2nd XV |
| Wirral 2nd XV | v | Fylde Hawks (2nd XV) |
| Saturday, 1 October 2022 |
| Caldy 2nd XV | v | Burnage 2nd XV |
| Chester 2nd XV | v | Stockport 2nd XV |
| Lymm 2nd XV | v | Blackburn 2nd XV |
| Preston Grasshoppers 2nd XV | v | Sandbach 2nd XV |
| Rossendale 2nd XV | v | Fylde Hawks (2nd XV) |
| Sedgley Park 2nd XV | v | Wirral 2nd XV |
| Saturday, 8 October 2022 |
| Blackburn 2nd XV | v | Fylde Hawks (2nd XV) |
| Saturday, 15 October 2022 |
| Blackburn 2nd XV | v | Chester 2nd XV |
| Burnage 2nd XV | v | Lymm 2nd XV |
| Sandbach 2nd XV | v | Fylde Hawks (2nd XV) |
| Sedgley Park 2nd XV | v | Caldy 2nd XV |
| Stockport 2nd XV | v | Preston Grasshoppers 2nd XV |
| Wirral 2nd XV | v | Rossendale 2nd XV |
| Saturday, 22 October 2022 |
| Caldy 2nd XV | v | Wirral 2nd XV |
| Chester 2nd XV | v | Burnage 2nd XV |
| Fylde Hawks (2nd XV) | v | Stockport 2nd XV |
| Lymm 2nd XV | v | Sedgley Park 2nd XV |
| Preston Grasshoppers 2nd XV | v | Blackburn 2nd XV |
| Rossendale 2nd XV | v | Sandbach 2nd XV |
| Saturday, 29 October 2022 |
| Burnage 2nd XV | v | Preston Grasshoppers 2nd XV |
| Caldy 2nd XV | v | Lymm 2nd XV |
| Sandbach 2nd XV | v | Wirral 2nd XV |
| Sedgley Park 2nd XV | v | Chester 2nd XV |
| Stockport 2nd XV | v | Rossendale 2nd XV |
| Saturday, 5 November 2022 |
| Chester 2nd XV | v | Caldy 2nd XV |
| Fylde Hawks (2nd XV) | v | Burnage 2nd XV |
| Lymm 2nd XV | v | Wirral 2nd XV |
| Preston Grasshoppers 2nd XV | v | Sedgley Park 2nd XV |
| Rossendale 2nd XV | v | Blackburn 2nd XV |
| Sandbach 2nd XV | v | Stockport 2nd XV |
| Saturday, 12 November 2022 |
| Burnage 2nd XV | v | Rossendale 2nd XV |
| Caldy 2nd XV | v | Preston Grasshoppers 2nd XV |
| Lymm 2nd XV | v | Chester 2nd XV |
| Sandbach 2nd XV | v | Blackburn 2nd XV |
| Sedgley Park 2nd XV | v | Fylde Hawks (2nd XV) |
| Wirral 2nd XV | v | Stockport 2nd XV |
| Saturday, 19 November 2022 |
| Preston Grasshoppers 2nd XV | v | Lymm 2nd XV |
| Saturday, 26 November 2022 |
| Chester 2nd XV | v | Wirral 2nd XV |
| Fylde Hawks (2nd XV) | v | Caldy 2nd XV |
| Rossendale 2nd XV | v | Sedgley Park 2nd XV |
| Sandbach 2nd XV | v | Burnage 2nd XV |
| Stockport 2nd XV | v | Blackburn 2nd XV |
| Saturday, 3 December 2022 |
| Burnage 2nd XV | v | Blackburn 2nd XV |
| Caldy 2nd XV | v | Sandbach 2nd XV |
| Chester 2nd XV | v | Fylde Hawks (2nd XV) |
| Lymm 2nd XV | v | Rossendale 2nd XV |
| Preston Grasshoppers 2nd XV | v | Wirral 2nd XV |
| Sedgley Park 2nd XV | v | Stockport 2nd XV |
| Saturday, 10 December 2022 |
| Fylde Hawks (2nd XV) | v | Preston Grasshoppers 2nd XV |
| Rossendale 2nd XV | v | Chester 2nd XV |
| Sandbach 2nd XV | v | Lymm 2nd XV |
| Sedgley Park 2nd XV | v | Blackburn 2nd XV |
| Stockport 2nd XV | v | Caldy 2nd XV |
| Wirral 2nd XV | v | Burnage 2nd XV |
| Saturday, 17 December 2022 |
| Caldy 2nd XV | v | Blackburn 2nd XV |
| Chester 2nd XV | v | Sandbach 2nd XV |
| Fylde Hawks (2nd XV) | v | Wirral 2nd XV |
| Lymm 2nd XV | v | Stockport 2nd XV |
| Preston Grasshoppers 2nd XV | v | Rossendale 2nd XV |
| Sedgley Park 2nd XV | v | Burnage 2nd XV |
| Saturday, 7 January 2023 |
| Blackburn 2nd XV | v | Lymm 2nd XV |
| Burnage 2nd XV | v | Caldy 2nd XV |
| Fylde Hawks (2nd XV) | v | Rossendale 2nd XV |
| Sandbach 2nd XV | v | Preston Grasshoppers 2nd XV |
| Stockport 2nd XV | v | Chester 2nd XV |
| Wirral 2nd XV | v | Sedgley Park 2nd XV |
| Saturday, 14 January 2023 |
| Caldy 2nd XV | v | Sedgley Park 2nd XV |
| Chester 2nd XV | v | Blackburn 2nd XV |
| Fylde Hawks (2nd XV) | v | Sandbach 2nd XV |
| Lymm 2nd XV | v | Burnage 2nd XV |
| Preston Grasshoppers 2nd XV | v | Stockport 2nd XV |
| Rossendale 2nd XV | v | Wirral 2nd XV |
| Saturday, 21 January 2023 |
| Blackburn 2nd XV | v | Preston Grasshoppers 2nd XV |
| Burnage 2nd XV | v | Chester 2nd XV |
| Sandbach 2nd XV | v | Rossendale 2nd XV |
| Sedgley Park 2nd XV | v | Lymm 2nd XV |
| Stockport 2nd XV | v | Fylde Hawks (2nd XV) |
| Wirral 2nd XV | v | Caldy 2nd XV |
| Saturday, 28 January 2023 |
| Chester 2nd XV | v | Sedgley Park 2nd XV |
| Fylde Hawks (2nd XV) | v | Blackburn 2nd XV |
| Lymm 2nd XV | v | Caldy 2nd XV |
| Preston Grasshoppers 2nd XV | v | Burnage 2nd XV |
| Rossendale 2nd XV | v | Stockport 2nd XV |
| Wirral 2nd XV | v | Sandbach 2nd XV |
| Saturday, 11 February 2023 |
| Blackburn 2nd XV | v | Rossendale 2nd XV |
| Burnage 2nd XV | v | Fylde Hawks (2nd XV) |
| Caldy 2nd XV | v | Chester 2nd XV |
| Sedgley Park 2nd XV | v | Preston Grasshoppers 2nd XV |
| Stockport 2nd XV | v | Sandbach 2nd XV |
| Wirral 2nd XV | v | Lymm 2nd XV |
| Saturday, 18 February 2023 |
| Blackburn 2nd XV | v | Sandbach 2nd XV |
| Chester 2nd XV | v | Lymm 2nd XV |
| Fylde Hawks (2nd XV) | v | Sedgley Park 2nd XV |
| Preston Grasshoppers 2nd XV | v | Caldy 2nd XV |
| Rossendale 2nd XV | v | Burnage 2nd XV |
| Stockport 2nd XV | v | Wirral 2nd XV |
| Saturday, 4 March 2023 |
| Blackburn 2nd XV | v | Stockport 2nd XV |
| Burnage 2nd XV | v | Sandbach 2nd XV |
| Caldy 2nd XV | v | Fylde Hawks (2nd XV) |
| Lymm 2nd XV | v | Preston Grasshoppers 2nd XV |
| Sedgley Park 2nd XV | v | Rossendale 2nd XV |
| Wirral 2nd XV | v | Chester 2nd XV |
| Saturday, 11 March 2023 |
| Fylde Hawks (2nd XV) | v | Lymm 2nd XV |
| Preston Grasshoppers 2nd XV | v | Chester 2nd XV |
| Rossendale 2nd XV | v | Caldy 2nd XV |
| Sandbach 2nd XV | v | Sedgley Park 2nd XV |
| Stockport 2nd XV | v | Burnage 2nd XV |
| Wirral 2nd XV | v | Blackburn 2nd XV |