| Saturday, 3 September 2022 |
| Bury 3rd XV | 65 | 5 | Carrington |
| Oldham 2nd XV | 0 | 8 | Wythenshawe |
| Saturday, 10 September 2022 |
| Carrington | 29 | 22 | Manchester Hawks |
| Eccles 3rd XV | 33 | 3 | Marple 3rd XV |
| Saturday, 17 September 2022 |
| Newcastle (Staffs) III | 31 | 28 | Wythenshawe |
| Oldham 2nd XV | 0 | 8 | Eccles 3rd XV |
| Saturday, 24 September 2022 |
| Bury 3rd XV | 52 | 17 | Oldham 2nd XV |
| Wythenshawe | 81 | 0 | Manchester Hawks |
| Saturday, 1 October 2022 |
| Carrington | 24 | 22 | Marple 3rd XV |
| Newcastle (Staffs) III | 22 | 0 | Eccles 3rd XV |
| Saturday, 8 October 2022 |
| Newcastle (Staffs) III | 24 | 3 | Manchester Hawks |
| Saturday, 15 October 2022 |
| Bury 3rd XV | 38 | 15 | Newcastle (Staffs) III |
| Carrington | 20 | 50 | Wythenshawe |
| Eccles 3rd XV | 26 | 19 | Manchester Hawks |
| Marple 3rd XV | Away Walkover | Oldham 2nd XV |
| Saturday, 22 October 2022 |
| Manchester Hawks | 36 | 5 | Bury 3rd XV |
| Oldham 2nd XV | Away Walkover | Carrington |
| Saturday, 29 October 2022 |
| Eccles 3rd XV | 28 | 10 | Wythenshawe |
| Marple 3rd XV | 37 | 10 | Newcastle (Staffs) III |
| Saturday, 5 November 2022 |
| Manchester Hawks | 29 | 10 | Marple 3rd XV |
| Newcastle (Staffs) III | 48 | 15 | Oldham 2nd XV |
| Wythenshawe | Home Walkover | Bury 3rd XV |
| Saturday, 12 November 2022 |
| Carrington | 19 | 26 | Eccles 3rd XV |
| Oldham 2nd XV | 12 | 20 | Manchester Hawks |
| Saturday, 19 November 2022 |
| Marple 3rd XV | 22 | 3 | Bury 3rd XV |
| Saturday, 26 November 2022 |
| Eccles 3rd XV | 59 | 19 | Bury 3rd XV |
| Newcastle (Staffs) III | 10 | 33 | Carrington |
| Wythenshawe | 16 | 44 | Marple 3rd XV |
| Saturday, 3 December 2022 |
| Manchester Hawks | 60 | 17 | Carrington |
| Marple 3rd XV | 5 | 29 | Eccles 3rd XV |
| Saturday, 17 December 2022 |
| Oldham 2nd XV | 0 | 7 | Bury 3rd XV |
| Saturday, 7 January 2023 |
| Eccles 3rd XV | 43 | 14 | Newcastle (Staffs) III |
| Marple 3rd XV | 36 | 7 | Carrington |
| Saturday, 14 January 2023 |
| Manchester Hawks | 36 | 21 | Eccles 3rd XV |
| Wythenshawe | 17 | 22 | Carrington |
| Saturday, 28 January 2023 |
| Bury 3rd XV | 15 | 64 | Manchester Hawks |
| Carrington | 17 | 5 | Oldham 2nd XV |
| Newcastle (Staffs) III | Home Walkover | Marple 3rd XV |
| Wythenshawe | 10 | 59 | Eccles 3rd XV |
| Saturday, 4 February 2023 |
| Manchester Hawks | 14 | 36 | Wythenshawe |
| Newcastle (Staffs) III | Home Walkover | Bury 3rd XV |
| Saturday, 11 February 2023 |
| Marple 3rd XV | 0 | 5 | Manchester Hawks |
| Oldham 2nd XV | 22 | 19 | Newcastle (Staffs) III |
| Wythenshawe | Home Walkover | Bury 3rd XV |
| Saturday, 18 February 2023 |
| Eccles 3rd XV | 57 | 5 | Carrington |
| Manchester Hawks | 65 | 5 | Oldham 2nd XV |
| Saturday, 25 February 2023 |
| Oldham 2nd XV | 14 | 25 | Marple 3rd XV |
| Saturday, 4 March 2023 |
| Bury 3rd XV | 28 | 85 | Eccles 3rd XV |
| Carrington | 40 | 14 | Newcastle (Staffs) III |
| Marple 3rd XV | Away Walkover | Wythenshawe |
| Saturday, 11 March 2023 |
| Carrington | 60 | 32 | Bury 3rd XV |
| Manchester Hawks | Home Walkover | Newcastle (Staffs) III |
| Wythenshawe | 50 | 12 | Oldham 2nd XV |
| Saturday, 18 March 2023 |
| Bury 3rd XV | 0 | 5 | Marple 3rd XV |
| Eccles 3rd XV | Home Walkover | Oldham 2nd XV |
| Wythenshawe | 67 | 12 | Newcastle (Staffs) III |