| Saturday, 3 September 2022 |
| Hope Valley | Home Walkover | Macclesfield 3rd XV |
| Lymm Eagles | 19 | 31 | Northwich 2nd XV |
| Winnington Park 2nd XV | 34 | 24 | Liverpool St Helens 2nd XV |
| Saturday, 10 September 2022 |
| Burnage 3rd XV | 20 | 14 | Lymm Eagles |
| Macclesfield 3rd XV | 60 | 22 | Heaton Moor 2nd XV |
| Northwich 2nd XV | Home Walkover | Liverpool St Helens 2nd XV |
| Saturday, 17 September 2022 |
| Liverpool St Helens 2nd XV | Home Walkover | Burnage 3rd XV |
| Lymm Eagles | 31 | 26 | Winnington Park 2nd XV |
| Saturday, 24 September 2022 |
| Heaton Moor 2nd XV | 12 | 47 | Lymm Eagles |
| Macclesfield 3rd XV | 26 | 27 | Northwich 2nd XV |
| Saturday, 1 October 2022 |
| Liverpool St Helens 2nd XV | 94 | 15 | Heaton Moor 2nd XV |
| Liverpool University Veterinarians | 34 | 7 | Macclesfield 3rd XV |
| Lymm Eagles | 46 | 12 | Hope Valley |
| Northwich 2nd XV | Home Walkover | Burnage 3rd XV |
| Saturday, 8 October 2022 |
| Heaton Moor 2nd XV | 43 | 22 | Liverpool University Veterinarians |
| Saturday, 15 October 2022 |
| Hope Valley | 8 | 21 | Liverpool St Helens 2nd XV |
| Winnington Park 2nd XV | 18 | 33 | Northwich 2nd XV |
| Saturday, 22 October 2022 |
| Burnage 3rd XV | 41 | 18 | Winnington Park 2nd XV |
| Lymm Eagles | 29 | 24 | Liverpool University Veterinarians |
| Northwich 2nd XV | 61 | 17 | Heaton Moor 2nd XV |
| Saturday, 29 October 2022 |
| Heaton Moor 2nd XV | 39 | 42 | Burnage 3rd XV |
| Hope Valley | 20 | 12 | Northwich 2nd XV |
| Liverpool University Veterinarians | 34 | 10 | Liverpool St Helens 2nd XV |
| Macclesfield 3rd XV | 34 | 5 | Winnington Park 2nd XV |
| Saturday, 5 November 2022 |
| Lymm Eagles | 35 | 23 | Macclesfield 3rd XV |
| Winnington Park 2nd XV | 14 | 26 | Heaton Moor 2nd XV |
| Saturday, 12 November 2022 |
| Hope Valley | 21 | 27 | Winnington Park 2nd XV |
| Liverpool University Veterinarians | 5 | 33 | Northwich 2nd XV |
| Lymm Eagles | 17 | 15 | Liverpool St Helens 2nd XV |
| Saturday, 19 November 2022 |
| Liverpool University Veterinarians | 40 | 5 | Winnington Park 2nd XV |
| Macclesfield 3rd XV | 36 | 10 | Burnage 3rd XV |
| Saturday, 26 November 2022 |
| Burnage 3rd XV | Away Walkover | Liverpool University Veterinarians |
| Heaton Moor 2nd XV | 48 | 24 | Hope Valley |
| Saturday, 3 December 2022 |
| Liverpool University Veterinarians | 46 | 10 | Heaton Moor 2nd XV |
| Lymm Eagles | 33 | 10 | Burnage 3rd XV |
| Northwich 2nd XV | Home Walkover | Liverpool St Helens 2nd XV |
| Saturday, 17 December 2022 |
| Liverpool St Helens 2nd XV | 5 | 0 | Winnington Park 2nd XV |
| Saturday, 7 January 2023 |
| Heaton Moor 2nd XV | 17 | 33 | Liverpool St Helens 2nd XV |
| Hope Valley | 22 | 31 | Lymm Eagles |
| Macclesfield 3rd XV | 40 | 27 | Liverpool University Veterinarians |
| Northwich 2nd XV | 56 | 5 | Burnage 3rd XV |
| Saturday, 14 January 2023 |
| Burnage 3rd XV | 5 | 5 | Macclesfield 3rd XV |
| Liverpool St Helens 2nd XV | Home Walkover | Hope Valley |
| Northwich 2nd XV | 32 | 7 | Winnington Park 2nd XV |
| Saturday, 21 January 2023 |
| Liverpool University Veterinarians | 0 | 5 | Lymm Eagles |
| Winnington Park 2nd XV | 5 | 0 | Burnage 3rd XV |
| Saturday, 28 January 2023 |
| Burnage 3rd XV | 14 | 7 | Heaton Moor 2nd XV |
| Liverpool St Helens 2nd XV | 39 | 17 | Liverpool University Veterinarians |
| Northwich 2nd XV | Home Walkover | Hope Valley |
| Winnington Park 2nd XV | 20 | 5 | Macclesfield 3rd XV |
| Saturday, 4 February 2023 |
| Lymm Eagles | Home Walkover | Heaton Moor 2nd XV |
| Northwich 2nd XV | 33 | 26 | Macclesfield 3rd XV |
| Saturday, 11 February 2023 |
| Heaton Moor 2nd XV | 33 | 7 | Winnington Park 2nd XV |
| Hope Valley | 15 | 24 | Burnage 3rd XV |
| Hope Valley | 15 | 24 | Burnage 3rd XV |
| Macclesfield 3rd XV | 31 | 43 | Lymm Eagles |
| Saturday, 18 February 2023 |
| Heaton Moor 2nd XV | 12 | 50 | Macclesfield 3rd XV |
| Liverpool St Helens 2nd XV | 38 | 33 | Lymm Eagles |
| Northwich 2nd XV | Home Walkover | Liverpool University Veterinarians |
| Winnington Park 2nd XV | 79 | 20 | Hope Valley |
| Saturday, 25 February 2023 |
| Heaton Moor 2nd XV | 5 | 14 | Northwich 2nd XV |
| Liverpool St Helens 2nd XV | Home Walkover | Macclesfield 3rd XV |
| Liverpool University Veterinarians | 57 | 5 | Hope Valley |
| Saturday, 4 March 2023 |
| Hope Valley | 7 | 76 | Heaton Moor 2nd XV |
| Liverpool St Helens 2nd XV | 48 | 5 | Macclesfield 3rd XV |
| Liverpool University Veterinarians | 73 | 0 | Burnage 3rd XV |
| Saturday, 11 March 2023 |
| Hope Valley | 0 | 8 | Macclesfield 3rd XV |
| Northwich 2nd XV | Home Walkover | Lymm Eagles |
| Winnington Park 2nd XV | Home Walkover | Liverpool University Veterinarians |
| Saturday, 18 March 2023 |
| Hope Valley | Home Walkover | Liverpool University Veterinarians |
| Liverpool St Helens 2nd XV | 62 | 0 | Burnage 3rd XV |
| Winnington Park 2nd XV | 35 | 26 | Lymm Eagles |