| Saturday, 3 September 2022 |
| Altrincham Kersal Cougars (2nd XV) | 19 | 55 | Knutsford |
| Bowdon 2nd XV | 20 | 29 | Manchester 2nd XV |
| Chester 3rd XV | 24 | 38 | Congleton |
| Didsbury Toc H 2nd XV | 14 | 7 | Holmes Chapel |
| Leek II | 47 | 14 | Wilmslow 2nd XV |
| Sandbach 3rd XV | 19 | 29 | Crewe & Nantwich 2nd XV |
| Saturday, 10 September 2022 |
| Congleton | 54 | 21 | Manchester 2nd XV |
| Holmes Chapel | 54 | 7 | Chester 3rd XV |
| Knutsford | 5 | 73 | Leek II |
| Sandbach 3rd XV | 19 | 38 | Didsbury Toc H 2nd XV |
| Wilmslow 2nd XV | Away Walkover | Crewe & Nantwich 2nd XV |
| Saturday, 17 September 2022 |
| Bowdon 2nd XV | 34 | 38 | Congleton |
| Chester 3rd XV | 5 | 66 | Sandbach 3rd XV |
| Crewe & Nantwich 2nd XV | 11 | 36 | Knutsford |
| Leek II | Home Walkover | Altrincham Kersal Cougars (2nd XV) |
| Manchester 2nd XV | 43 | 17 | Holmes Chapel |
| Saturday, 24 September 2022 |
| Crewe & Nantwich 2nd XV | 24 | 17 | Altrincham Kersal Cougars (2nd XV) |
| Knutsford | 0 | 45 | Didsbury Toc H 2nd XV |
| Sandbach 3rd XV | 29 | 34 | Manchester 2nd XV |
| Wilmslow 2nd XV | 33 | 17 | Chester 3rd XV |
| Saturday, 1 October 2022 |
| Bowdon 2nd XV | 17 | 37 | Holmes Chapel |
| Chester 3rd XV | 57 | 41 | Knutsford |
| Congleton | 29 | 35 | Sandbach 3rd XV |
| Crewe & Nantwich 2nd XV | 7 | 41 | Leek II |
| Didsbury Toc H 2nd XV | 90 | 19 | Altrincham Kersal Cougars (2nd XV) |
| Manchester 2nd XV | 53 | 7 | Wilmslow 2nd XV |
| Saturday, 8 October 2022 |
| Altrincham Kersal Cougars (2nd XV) | 10 | 52 | Bowdon 2nd XV |
| Saturday, 15 October 2022 |
| Altrincham Kersal Cougars (2nd XV) | 12 | 23 | Chester 3rd XV |
| Crewe & Nantwich 2nd XV | 36 | 34 | Bowdon 2nd XV |
| Knutsford | 10 | 37 | Manchester 2nd XV |
| Leek II | 26 | 26 | Didsbury Toc H 2nd XV |
| Sandbach 3rd XV | 26 | 24 | Holmes Chapel |
| Wilmslow 2nd XV | 17 | 57 | Congleton |
| Saturday, 22 October 2022 |
| Bowdon 2nd XV | 17 | 35 | Sandbach 3rd XV |
| Chester 3rd XV | 19 | 67 | Leek II |
| Congleton | 57 | 12 | Knutsford |
| Didsbury Toc H 2nd XV | 73 | 14 | Crewe & Nantwich 2nd XV |
| Holmes Chapel | Home Walkover | Wilmslow 2nd XV |
| Manchester 2nd XV | 80 | 7 | Altrincham Kersal Cougars (2nd XV) |
| Saturday, 29 October 2022 |
| Altrincham Kersal Cougars (2nd XV) | 10 | 43 | Congleton |
| Bowdon 2nd XV | 26 | 38 | Didsbury Toc H 2nd XV |
| Crewe & Nantwich 2nd XV | 36 | 27 | Chester 3rd XV |
| Knutsford | 17 | 22 | Holmes Chapel |
| Leek II | 24 | 10 | Manchester 2nd XV |
| Wilmslow 2nd XV | Away Walkover | Sandbach 3rd XV |
| Saturday, 5 November 2022 |
| Bowdon 2nd XV | 22 | 38 | Wilmslow 2nd XV |
| Congleton | 27 | 14 | Leek II |
| Didsbury Toc H 2nd XV | Home Walkover | Chester 3rd XV |
| Holmes Chapel | 35 | 12 | Altrincham Kersal Cougars (2nd XV) |
| Manchester 2nd XV | 43 | 7 | Crewe & Nantwich 2nd XV |
| Sandbach 3rd XV | 43 | 36 | Knutsford |
| Saturday, 12 November 2022 |
| Altrincham Kersal Cougars (2nd XV) | 5 | 26 | Sandbach 3rd XV |
| Chester 3rd XV | 83 | 14 | Bowdon 2nd XV |
| Congleton | 40 | 12 | Crewe & Nantwich 2nd XV |
| Didsbury Toc H 2nd XV | 10 | 24 | Manchester 2nd XV |
| Knutsford | 41 | 24 | Wilmslow 2nd XV |
| Leek II | 75 | 5 | Holmes Chapel |
| Saturday, 19 November 2022 |
| Didsbury Toc H 2nd XV | 33 | 15 | Wilmslow 2nd XV |
| Saturday, 26 November 2022 |
| Congleton | 24 | 45 | Didsbury Toc H 2nd XV |
| Holmes Chapel | 41 | 10 | Crewe & Nantwich 2nd XV |
| Knutsford | 43 | 10 | Bowdon 2nd XV |
| Manchester 2nd XV | 71 | 10 | Chester 3rd XV |
| Sandbach 3rd XV | 31 | 18 | Leek II |
| Wilmslow 2nd XV | 15 | 31 | Altrincham Kersal Cougars (2nd XV) |
| Saturday, 3 December 2022 |
| Bowdon 2nd XV | 24 | 36 | Altrincham Kersal Cougars (2nd XV) |
| Chester 3rd XV | 27 | 15 | Holmes Chapel |
| Crewe & Nantwich 2nd XV | 24 | 22 | Wilmslow 2nd XV |
| Didsbury Toc H 2nd XV | 33 | 26 | Sandbach 3rd XV |
| Manchester 2nd XV | 23 | 20 | Congleton |
| Saturday, 10 December 2022 |
| Sandbach 3rd XV | 35 | 12 | Chester 3rd XV |
| Saturday, 17 December 2022 |
| Didsbury Toc H 2nd XV | Home Walkover | Knutsford |
| Friday, 6 January 2023 |
| Sandbach 3rd XV | 8 | 20 | Congleton |
| Saturday, 7 January 2023 |
| Altrincham Kersal Cougars (2nd XV) | 7 | 37 | Didsbury Toc H 2nd XV |
| Holmes Chapel | 27 | 6 | Bowdon 2nd XV |
| Knutsford | 22 | 29 | Chester 3rd XV |
| Leek II | 33 | 7 | Crewe & Nantwich 2nd XV |
| Wilmslow 2nd XV | 7 | 45 | Manchester 2nd XV |
| Saturday, 14 January 2023 |
| Bowdon 2nd XV | 31 | 14 | Crewe & Nantwich 2nd XV |
| Chester 3rd XV | 20 | 31 | Altrincham Kersal Cougars (2nd XV) |
| Congleton | 33 | 10 | Wilmslow 2nd XV |
| Didsbury Toc H 2nd XV | 33 | 34 | Leek II |
| Holmes Chapel | 23 | 22 | Sandbach 3rd XV |
| Manchester 2nd XV | 69 | 5 | Knutsford |
| Saturday, 21 January 2023 |
| Holmes Chapel | 5 | 0 | Wilmslow 2nd XV |
| Knutsford | 0 | 5 | Congleton |
| Leek II | 5 | 0 | Chester 3rd XV |
| Sandbach 3rd XV | 5 | 0 | Bowdon 2nd XV |
| Saturday, 28 January 2023 |
| Chester 3rd XV | 22 | 26 | Crewe & Nantwich 2nd XV |
| Congleton | 65 | 7 | Altrincham Kersal Cougars (2nd XV) |
| Didsbury Toc H 2nd XV | 76 | 7 | Bowdon 2nd XV |
| Holmes Chapel | 16 | 5 | Knutsford |
| Manchester 2nd XV | 36 | 29 | Leek II |
| Sandbach 3rd XV | 52 | 12 | Wilmslow 2nd XV |
| Saturday, 4 February 2023 |
| Altrincham Kersal Cougars (2nd XV) | 36 | 29 | Crewe & Nantwich 2nd XV |
| Chester 3rd XV | 70 | 12 | Wilmslow 2nd XV |
| Holmes Chapel | 13 | 18 | Congleton |
| Leek II | Home Walkover | Knutsford |
| Manchester 2nd XV | 62 | 10 | Sandbach 3rd XV |
| Saturday, 11 February 2023 |
| Altrincham Kersal Cougars (2nd XV) | 12 | 60 | Holmes Chapel |
| Crewe & Nantwich 2nd XV | 10 | 43 | Manchester 2nd XV |
| Didsbury Toc H 2nd XV | 50 | 8 | Chester 3rd XV |
| Knutsford | 19 | 14 | Sandbach 3rd XV |
| Leek II | 34 | 24 | Congleton |
| Wilmslow 2nd XV | 45 | 34 | Bowdon 2nd XV |
| Saturday, 18 February 2023 |
| Altrincham Kersal Cougars (2nd XV) | 12 | 50 | Sandbach 3rd XV |
| Bowdon 2nd XV | 35 | 21 | Chester 3rd XV |
| Crewe & Nantwich 2nd XV | 17 | 29 | Congleton |
| Holmes Chapel | 27 | 7 | Leek II |
| Manchester 2nd XV | 39 | 29 | Didsbury Toc H 2nd XV |
| Wilmslow 2nd XV | 76 | 14 | Knutsford |
| Saturday, 25 February 2023 |
| Altrincham Kersal Cougars (2nd XV) | 0 | 82 | Manchester 2nd XV |
| Congleton | 82 | 21 | Holmes Chapel |
| Crewe & Nantwich 2nd XV | 22 | 17 | Didsbury Toc H 2nd XV |
| Leek II | 40 | 39 | Bowdon 2nd XV |
| Leek II | 40 | 39 | Bowdon 2nd XV |
| Saturday, 4 March 2023 |
| Altrincham Kersal Cougars (2nd XV) | 24 | 36 | Wilmslow 2nd XV |
| Bowdon 2nd XV | 31 | 29 | Knutsford |
| Chester 3rd XV | 5 | 38 | Manchester 2nd XV |
| Crewe & Nantwich 2nd XV | 25 | 24 | Holmes Chapel |
| Didsbury Toc H 2nd XV | 36 | 48 | Congleton |
| Leek II | 38 | 14 | Sandbach 3rd XV |
| Saturday, 11 March 2023 |
| Congleton | Away Walkover | Chester 3rd XV |
| Crewe & Nantwich 2nd XV | 12 | 17 | Sandbach 3rd XV |
| Holmes Chapel | 13 | 21 | Didsbury Toc H 2nd XV |
| Knutsford | 27 | 17 | Altrincham Kersal Cougars (2nd XV) |
| Manchester 2nd XV | 43 | 19 | Bowdon 2nd XV |
| Wilmslow 2nd XV | 22 | 33 | Leek II |
| Saturday, 18 March 2023 |
| Congleton | Away Walkover | Bowdon 2nd XV |
| Holmes Chapel | 26 | 31 | Manchester 2nd XV |
| Knutsford | 13 | 17 | Crewe & Nantwich 2nd XV |
| Leek II | Home Walkover | Altrincham Kersal Cougars (2nd XV) |
| Wilmslow 2nd XV | 10 | 7 | Didsbury Toc H 2nd XV |