| Saturday, 3 September 2022 |
| Broughton Park 2nd XV | 17 | 29 | Glossop 2nd XV |
| Macclesfield 2nd XV | 36 | 19 | Firwood Waterloo 2nd XV |
| Tarleton 2nd XV | 7 | 12 | Rochdale 2nd XV |
| Vale of Lune 2nd XV | 26 | 21 | Birkenhead Park Wanderers (2nd XV) |
| Saturday, 10 September 2022 |
| Glossop 2nd XV | 12 | 15 | Macclesfield 2nd XV |
| Rochdale 2nd XV | 24 | 19 | Broughton Park 2nd XV |
| Sedgley Park 3rd XV | 7 | 46 | Firwood Waterloo 2nd XV |
| Vale of Lune 2nd XV | 38 | 22 | Tarleton 2nd XV |
| Saturday, 17 September 2022 |
| Anselmians 2nd XV | 53 | 5 | Sedgley Park 3rd XV |
| Birkenhead Park Wanderers (2nd XV) | 24 | 17 | Kendal 2nd XV |
| Firwood Waterloo 2nd XV | 48 | 7 | Glossop 2nd XV |
| Macclesfield 2nd XV | 22 | 17 | Rochdale 2nd XV |
| Vale of Lune 2nd XV | 33 | 19 | Broughton Park 2nd XV |
| Saturday, 24 September 2022 |
| Anselmians 2nd XV | 27 | 5 | Birkenhead Park Wanderers (2nd XV) |
| Kendal 2nd XV | Home Walkover | Tarleton 2nd XV |
| Rochdale 2nd XV | 36 | 20 | Firwood Waterloo 2nd XV |
| Sedgley Park 3rd XV | 0 | 47 | Glossop 2nd XV |
| Vale of Lune 2nd XV | 27 | 17 | Macclesfield 2nd XV |
| Saturday, 1 October 2022 |
| Birkenhead Park Wanderers (2nd XV) | 68 | 5 | Sedgley Park 3rd XV |
| Broughton Park 2nd XV | 26 | 67 | Kendal 2nd XV |
| Glossop 2nd XV | 20 | 10 | Rochdale 2nd XV |
| Tarleton 2nd XV | 13 | 53 | Anselmians 2nd XV |
| Vale of Lune 2nd XV | 30 | 22 | Firwood Waterloo 2nd XV |
| Saturday, 8 October 2022 |
| Kendal 2nd XV | 42 | 21 | Sedgley Park 3rd XV |
| Saturday, 15 October 2022 |
| Anselmians 2nd XV | 50 | 0 | Broughton Park 2nd XV |
| Glossop 2nd XV | 30 | 10 | Vale of Lune 2nd XV |
| Kendal 2nd XV | 10 | 34 | Macclesfield 2nd XV |
| Sedgley Park 3rd XV | 14 | 45 | Rochdale 2nd XV |
| Saturday, 22 October 2022 |
| Broughton Park 2nd XV | 8 | 38 | Birkenhead Park Wanderers (2nd XV) |
| Firwood Waterloo 2nd XV | 52 | 43 | Kendal 2nd XV |
| Macclesfield 2nd XV | 62 | 16 | Anselmians 2nd XV |
| Tarleton 2nd XV | 61 | 5 | Sedgley Park 3rd XV |
| Vale of Lune 2nd XV | 31 | 7 | Rochdale 2nd XV |
| Saturday, 29 October 2022 |
| Anselmians 2nd XV | 10 | 33 | Firwood Waterloo 2nd XV |
| Birkenhead Park Wanderers (2nd XV) | 26 | 42 | Macclesfield 2nd XV |
| Kendal 2nd XV | 22 | 19 | Glossop 2nd XV |
| Sedgley Park 3rd XV | 45 | 19 | Vale of Lune 2nd XV |
| Tarleton 2nd XV | 0 | 31 | Broughton Park 2nd XV |
| Saturday, 5 November 2022 |
| Anselmians 2nd XV | 15 | 21 | Glossop 2nd XV |
| Broughton Park 2nd XV | 17 | 27 | Sedgley Park 3rd XV |
| Firwood Waterloo 2nd XV | 10 | 39 | Birkenhead Park Wanderers (2nd XV) |
| Macclesfield 2nd XV | 45 | 10 | Tarleton 2nd XV |
| Rochdale 2nd XV | 32 | 14 | Kendal 2nd XV |
| Saturday, 12 November 2022 |
| Broughton Park 2nd XV | 5 | 54 | Macclesfield 2nd XV |
| Glossop 2nd XV | Home Walkover | Birkenhead Park Wanderers (2nd XV) |
| Kendal 2nd XV | 55 | 3 | Vale of Lune 2nd XV |
| Rochdale 2nd XV | 21 | 14 | Anselmians 2nd XV |
| Tarleton 2nd XV | 19 | 24 | Firwood Waterloo 2nd XV |
| Saturday, 19 November 2022 |
| Birkenhead Park Wanderers (2nd XV) | 92 | 21 | Tarleton 2nd XV |
| Saturday, 26 November 2022 |
| Anselmians 2nd XV | Home Walkover | Vale of Lune 2nd XV |
| Birkenhead Park Wanderers (2nd XV) | 43 | 0 | Rochdale 2nd XV |
| Firwood Waterloo 2nd XV | Home Walkover | Broughton Park 2nd XV |
| Glossop 2nd XV | Home Walkover | Tarleton 2nd XV |
| Macclesfield 2nd XV | Home Walkover | Sedgley Park 3rd XV |
| Saturday, 3 December 2022 |
| Anselmians 2nd XV | 30 | 14 | Kendal 2nd XV |
| Broughton Park 2nd XV | 17 | 20 | Rochdale 2nd XV |
| Firwood Waterloo 2nd XV | 21 | 10 | Sedgley Park 3rd XV |
| Macclesfield 2nd XV | 40 | 5 | Glossop 2nd XV |
| Tarleton 2nd XV | 48 | 5 | Vale of Lune 2nd XV |
| Saturday, 7 January 2023 |
| Anselmians 2nd XV | 73 | 14 | Tarleton 2nd XV |
| Firwood Waterloo 2nd XV | 34 | 26 | Vale of Lune 2nd XV |
| Kendal 2nd XV | 24 | 33 | Broughton Park 2nd XV |
| Rochdale 2nd XV | 20 | 19 | Glossop 2nd XV |
| Sedgley Park 3rd XV | 0 | 57 | Birkenhead Park Wanderers (2nd XV) |
| Saturday, 14 January 2023 |
| Broughton Park 2nd XV | 20 | 10 | Anselmians 2nd XV |
| Macclesfield 2nd XV | Home Walkover | Kendal 2nd XV |
| Tarleton 2nd XV | 22 | 17 | Birkenhead Park Wanderers (2nd XV) |
| Vale of Lune 2nd XV | 25 | 0 | Glossop 2nd XV |
| Saturday, 21 January 2023 |
| Birkenhead Park Wanderers (2nd XV) | 5 | 0 | Broughton Park 2nd XV |
| Kendal 2nd XV | 22 | 17 | Firwood Waterloo 2nd XV |
| Rochdale 2nd XV | 5 | 0 | Vale of Lune 2nd XV |
| Saturday, 28 January 2023 |
| Broughton Park 2nd XV | 33 | 15 | Tarleton 2nd XV |
| Firwood Waterloo 2nd XV | 34 | 5 | Anselmians 2nd XV |
| Glossop 2nd XV | Home Walkover | Kendal 2nd XV |
| Macclesfield 2nd XV | 25 | 0 | Birkenhead Park Wanderers (2nd XV) |
| Vale of Lune 2nd XV | 33 | 5 | Sedgley Park 3rd XV |
| Saturday, 4 February 2023 |
| Broughton Park 2nd XV | 45 | 0 | Vale of Lune 2nd XV |
| Firwood Waterloo 2nd XV | 33 | 10 | Rochdale 2nd XV |
| Glossop 2nd XV | 68 | 7 | Sedgley Park 3rd XV |
| Kendal 2nd XV | Home Walkover | Anselmians 2nd XV |
| Saturday, 11 February 2023 |
| Birkenhead Park Wanderers (2nd XV) | 71 | 7 | Firwood Waterloo 2nd XV |
| Glossop 2nd XV | 5 | 19 | Anselmians 2nd XV |
| Kendal 2nd XV | 47 | 12 | Rochdale 2nd XV |
| Sedgley Park 3rd XV | 33 | 22 | Broughton Park 2nd XV |
| Tarleton 2nd XV | 25 | 24 | Macclesfield 2nd XV |
| Saturday, 18 February 2023 |
| Anselmians 2nd XV | 38 | 23 | Rochdale 2nd XV |
| Firwood Waterloo 2nd XV | 32 | 15 | Tarleton 2nd XV |
| Glossop 2nd XV | 0 | 49 | Birkenhead Park Wanderers (2nd XV) |
| Macclesfield 2nd XV | 44 | 7 | Broughton Park 2nd XV |
| Vale of Lune 2nd XV | 27 | 17 | Kendal 2nd XV |
| Saturday, 25 February 2023 |
| Birkenhead Park Wanderers (2nd XV) | 28 | 31 | Anselmians 2nd XV |
| Kendal 2nd XV | 95 | 5 | Tarleton 2nd XV |
| Macclesfield 2nd XV | 48 | 13 | Vale of Lune 2nd XV |
| Rochdale 2nd XV | 45 | 14 | Sedgley Park 3rd XV |
| Saturday, 4 March 2023 |
| Firwood Waterloo 2nd XV | 57 | 28 | Broughton Park 2nd XV |
| Glossop 2nd XV | 42 | 8 | Tarleton 2nd XV |
| Macclesfield 2nd XV | 80 | 15 | Sedgley Park 3rd XV |
| Rochdale 2nd XV | 12 | 66 | Birkenhead Park Wanderers (2nd XV) |
| Vale of Lune 2nd XV | 17 | 38 | Anselmians 2nd XV |
| Saturday, 11 March 2023 |
| Birkenhead Park Wanderers (2nd XV) | Home Walkover | Vale of Lune 2nd XV |
| Firwood Waterloo 2nd XV | Home Walkover | Macclesfield 2nd XV |
| Glossop 2nd XV | 8 | 0 | Broughton Park 2nd XV |
| Rochdale 2nd XV | 8 | 0 | Tarleton 2nd XV |
| Sedgley Park 3rd XV | 12 | 26 | Kendal 2nd XV |
| Saturday, 18 March 2023 |
| Glossop 2nd XV | Home Walkover | Firwood Waterloo 2nd XV |
| Kendal 2nd XV | 40 | 29 | Birkenhead Park Wanderers (2nd XV) |
| Rochdale 2nd XV | 0 | 48 | Macclesfield 2nd XV |
| Sedgley Park 3rd XV | 21 | 24 | Anselmians 2nd XV |
| Saturday, 25 March 2023 |
| Anselmians 2nd XV | 41 | 10 | Macclesfield 2nd XV |
| Sedgley Park 3rd XV | 38 | 31 | Tarleton 2nd XV |