| Saturday, 3 September 2022 |
| Anselmians 2nd XV | v | Warrington 2nd XV |
| Broughton Park 2nd XV | v | Glossop 2nd XV |
| Kendal 2nd XV | v | Sedgley Park 3rd XV |
| Macclesfield 2nd XV | v | Firwood Waterloo 2nd XV |
| Tarleton 2nd XV | v | Rochdale 2nd XV |
| Vale of Lune 2nd XV | v | Birkenhead Park Wanderers (2nd XV) |
| Saturday, 10 September 2022 |
| Glossop 2nd XV | v | Macclesfield 2nd XV |
| Kendal 2nd XV | v | Anselmians 2nd XV |
| Rochdale 2nd XV | v | Broughton Park 2nd XV |
| Sedgley Park 3rd XV | v | Firwood Waterloo 2nd XV |
| Vale of Lune 2nd XV | v | Tarleton 2nd XV |
| Warrington 2nd XV | v | Birkenhead Park Wanderers (2nd XV) |
| Saturday, 17 September 2022 |
| Anselmians 2nd XV | v | Sedgley Park 3rd XV |
| Birkenhead Park Wanderers (2nd XV) | v | Kendal 2nd XV |
| Firwood Waterloo 2nd XV | v | Glossop 2nd XV |
| Macclesfield 2nd XV | v | Rochdale 2nd XV |
| Tarleton 2nd XV | v | Warrington 2nd XV |
| Vale of Lune 2nd XV | v | Broughton Park 2nd XV |
| Saturday, 24 September 2022 |
| Anselmians 2nd XV | v | Birkenhead Park Wanderers (2nd XV) |
| Kendal 2nd XV | v | Tarleton 2nd XV |
| Rochdale 2nd XV | v | Firwood Waterloo 2nd XV |
| Sedgley Park 3rd XV | v | Glossop 2nd XV |
| Vale of Lune 2nd XV | v | Macclesfield 2nd XV |
| Warrington 2nd XV | v | Broughton Park 2nd XV |
| Saturday, 1 October 2022 |
| Birkenhead Park Wanderers (2nd XV) | v | Sedgley Park 3rd XV |
| Broughton Park 2nd XV | v | Kendal 2nd XV |
| Glossop 2nd XV | v | Rochdale 2nd XV |
| Macclesfield 2nd XV | v | Warrington 2nd XV |
| Tarleton 2nd XV | v | Anselmians 2nd XV |
| Vale of Lune 2nd XV | v | Firwood Waterloo 2nd XV |
| Saturday, 15 October 2022 |
| Anselmians 2nd XV | v | Broughton Park 2nd XV |
| Birkenhead Park Wanderers (2nd XV) | v | Tarleton 2nd XV |
| Glossop 2nd XV | v | Vale of Lune 2nd XV |
| Kendal 2nd XV | v | Macclesfield 2nd XV |
| Sedgley Park 3rd XV | v | Rochdale 2nd XV |
| Warrington 2nd XV | v | Firwood Waterloo 2nd XV |
| Saturday, 22 October 2022 |
| Broughton Park 2nd XV | v | Birkenhead Park Wanderers (2nd XV) |
| Firwood Waterloo 2nd XV | v | Kendal 2nd XV |
| Glossop 2nd XV | v | Warrington 2nd XV |
| Macclesfield 2nd XV | v | Anselmians 2nd XV |
| Tarleton 2nd XV | v | Sedgley Park 3rd XV |
| Vale of Lune 2nd XV | v | Rochdale 2nd XV |
| Saturday, 29 October 2022 |
| Anselmians 2nd XV | v | Firwood Waterloo 2nd XV |
| Birkenhead Park Wanderers (2nd XV) | v | Macclesfield 2nd XV |
| Kendal 2nd XV | v | Glossop 2nd XV |
| Rochdale 2nd XV | v | Warrington 2nd XV |
| Sedgley Park 3rd XV | v | Vale of Lune 2nd XV |
| Tarleton 2nd XV | v | Broughton Park 2nd XV |
| Saturday, 5 November 2022 |
| Broughton Park 2nd XV | v | Sedgley Park 3rd XV |
| Firwood Waterloo 2nd XV | v | Birkenhead Park Wanderers (2nd XV) |
| Glossop 2nd XV | v | Anselmians 2nd XV |
| Macclesfield 2nd XV | v | Tarleton 2nd XV |
| Rochdale 2nd XV | v | Kendal 2nd XV |
| Warrington 2nd XV | v | Vale of Lune 2nd XV |
| Saturday, 12 November 2022 |
| Anselmians 2nd XV | v | Rochdale 2nd XV |
| Broughton Park 2nd XV | v | Macclesfield 2nd XV |
| Glossop 2nd XV | v | Birkenhead Park Wanderers (2nd XV) |
| Kendal 2nd XV | v | Vale of Lune 2nd XV |
| Tarleton 2nd XV | v | Firwood Waterloo 2nd XV |
| Warrington 2nd XV | v | Sedgley Park 3rd XV |
| Saturday, 26 November 2022 |
| Anselmians 2nd XV | v | Vale of Lune 2nd XV |
| Birkenhead Park Wanderers (2nd XV) | v | Rochdale 2nd XV |
| Firwood Waterloo 2nd XV | v | Broughton Park 2nd XV |
| Glossop 2nd XV | v | Tarleton 2nd XV |
| Macclesfield 2nd XV | v | Sedgley Park 3rd XV |
| Warrington 2nd XV | v | Kendal 2nd XV |
| Saturday, 3 December 2022 |
| Anselmians 2nd XV | v | Kendal 2nd XV |
| Birkenhead Park Wanderers (2nd XV) | v | Warrington 2nd XV |
| Broughton Park 2nd XV | v | Rochdale 2nd XV |
| Firwood Waterloo 2nd XV | v | Sedgley Park 3rd XV |
| Macclesfield 2nd XV | v | Glossop 2nd XV |
| Tarleton 2nd XV | v | Vale of Lune 2nd XV |
| Saturday, 10 December 2022 |
| Broughton Park 2nd XV | v | Vale of Lune 2nd XV |
| Glossop 2nd XV | v | Firwood Waterloo 2nd XV |
| Kendal 2nd XV | v | Birkenhead Park Wanderers (2nd XV) |
| Rochdale 2nd XV | v | Macclesfield 2nd XV |
| Sedgley Park 3rd XV | v | Anselmians 2nd XV |
| Warrington 2nd XV | v | Tarleton 2nd XV |
| Saturday, 17 December 2022 |
| Birkenhead Park Wanderers (2nd XV) | v | Anselmians 2nd XV |
| Broughton Park 2nd XV | v | Warrington 2nd XV |
| Firwood Waterloo 2nd XV | v | Rochdale 2nd XV |
| Glossop 2nd XV | v | Sedgley Park 3rd XV |
| Macclesfield 2nd XV | v | Vale of Lune 2nd XV |
| Tarleton 2nd XV | v | Kendal 2nd XV |
| Saturday, 7 January 2023 |
| Anselmians 2nd XV | v | Tarleton 2nd XV |
| Firwood Waterloo 2nd XV | v | Vale of Lune 2nd XV |
| Kendal 2nd XV | v | Broughton Park 2nd XV |
| Rochdale 2nd XV | v | Glossop 2nd XV |
| Sedgley Park 3rd XV | v | Birkenhead Park Wanderers (2nd XV) |
| Warrington 2nd XV | v | Macclesfield 2nd XV |
| Saturday, 14 January 2023 |
| Broughton Park 2nd XV | v | Anselmians 2nd XV |
| Firwood Waterloo 2nd XV | v | Warrington 2nd XV |
| Macclesfield 2nd XV | v | Kendal 2nd XV |
| Rochdale 2nd XV | v | Sedgley Park 3rd XV |
| Tarleton 2nd XV | v | Birkenhead Park Wanderers (2nd XV) |
| Vale of Lune 2nd XV | v | Glossop 2nd XV |
| Saturday, 21 January 2023 |
| Anselmians 2nd XV | v | Macclesfield 2nd XV |
| Birkenhead Park Wanderers (2nd XV) | v | Broughton Park 2nd XV |
| Kendal 2nd XV | v | Firwood Waterloo 2nd XV |
| Rochdale 2nd XV | v | Vale of Lune 2nd XV |
| Sedgley Park 3rd XV | v | Tarleton 2nd XV |
| Warrington 2nd XV | v | Glossop 2nd XV |
| Saturday, 28 January 2023 |
| Broughton Park 2nd XV | v | Tarleton 2nd XV |
| Firwood Waterloo 2nd XV | v | Anselmians 2nd XV |
| Glossop 2nd XV | v | Kendal 2nd XV |
| Macclesfield 2nd XV | v | Birkenhead Park Wanderers (2nd XV) |
| Vale of Lune 2nd XV | v | Sedgley Park 3rd XV |
| Warrington 2nd XV | v | Rochdale 2nd XV |
| Saturday, 11 February 2023 |
| Anselmians 2nd XV | v | Glossop 2nd XV |
| Birkenhead Park Wanderers (2nd XV) | v | Firwood Waterloo 2nd XV |
| Kendal 2nd XV | v | Rochdale 2nd XV |
| Sedgley Park 3rd XV | v | Broughton Park 2nd XV |
| Tarleton 2nd XV | v | Macclesfield 2nd XV |
| Vale of Lune 2nd XV | v | Warrington 2nd XV |
| Saturday, 18 February 2023 |
| Birkenhead Park Wanderers (2nd XV) | v | Glossop 2nd XV |
| Firwood Waterloo 2nd XV | v | Tarleton 2nd XV |
| Macclesfield 2nd XV | v | Broughton Park 2nd XV |
| Rochdale 2nd XV | v | Anselmians 2nd XV |
| Sedgley Park 3rd XV | v | Warrington 2nd XV |
| Vale of Lune 2nd XV | v | Kendal 2nd XV |
| Saturday, 4 March 2023 |
| Broughton Park 2nd XV | v | Firwood Waterloo 2nd XV |
| Kendal 2nd XV | v | Warrington 2nd XV |
| Rochdale 2nd XV | v | Birkenhead Park Wanderers (2nd XV) |
| Sedgley Park 3rd XV | v | Macclesfield 2nd XV |
| Tarleton 2nd XV | v | Glossop 2nd XV |
| Vale of Lune 2nd XV | v | Anselmians 2nd XV |
| Saturday, 11 March 2023 |
| Birkenhead Park Wanderers (2nd XV) | v | Vale of Lune 2nd XV |
| Firwood Waterloo 2nd XV | v | Macclesfield 2nd XV |
| Glossop 2nd XV | v | Broughton Park 2nd XV |
| Rochdale 2nd XV | v | Tarleton 2nd XV |
| Sedgley Park 3rd XV | v | Kendal 2nd XV |
| Warrington 2nd XV | v | Anselmians 2nd XV |