| Saturday, 4 September 2021 |
| Anselmians 3rd XV | 17 | 14 | Wallasey 2nd XV |
| Saturday, 11 September 2021 |
| Anselmians 3rd XV | 7 | 27 | Merseyside Police |
| Saturday, 18 September 2021 |
| Merseyside Police | 10 | 20 | Wallasey 2nd XV |
| Saturday, 25 September 2021 |
| Anselmians 3rd XV | 29 | 36 | Hoylake 2nd XV |
| Merseyside Police | 81 | 17 | Wirral 4th XV |
| Wallasey 2nd XV | 5 | 19 | Oldershaw 2nd XV |
| Saturday, 2 October 2021 |
| Hoylake 2nd XV | 7 | 25 | Merseyside Police |
| Oldershaw 2nd XV | 38 | 0 | Oxton Parkonians 2nd XV |
| Wirral 4th XV | 47 | 0 | Wallasey 2nd XV |
| Saturday, 9 October 2021 |
| Wirral 4th XV | 7 | 38 | Anselmians 3rd XV |
| Saturday, 16 October 2021 |
| Wallasey 2nd XV | 21 | 24 | Oxton Parkonians 2nd XV |
| Wirral 4th XV | 47 | 7 | Hoylake 2nd XV |
| Saturday, 23 October 2021 |
| Hoylake 2nd XV | 36 | 34 | Wallasey 2nd XV |
| Saturday, 13 November 2021 |
| Oldershaw 2nd XV | 12 | 17 | Anselmians 3rd XV |
| Saturday, 20 November 2021 |
| Anselmians 3rd XV | 85 | 5 | Oxton Parkonians 2nd XV |
| Merseyside Police | Away Walkover | Oldershaw 2nd XV |
| Saturday, 27 November 2021 |
| Oldershaw 2nd XV | Home Walkover | Wirral 4th XV |
| Oxton Parkonians 2nd XV | 10 | 29 | Merseyside Police |
| Saturday, 4 December 2021 |
| Wirral 4th XV | Away Walkover | Oxton Parkonians 2nd XV |
| Saturday, 11 December 2021 |
| Oxton Parkonians 2nd XV | Away Walkover | Hoylake 2nd XV |
| Saturday, 8 January 2022 |
| Anselmians 3rd XV | 0 | 32 | Wirral 4th XV |
| Wallasey 2nd XV | 24 | 38 | Merseyside Police |
| Saturday, 15 January 2022 |
| Hoylake 2nd XV | 0 | 21 | Anselmians 3rd XV |
| Oldershaw 2nd XV | 15 | 7 | Wallasey 2nd XV |
| Saturday, 22 January 2022 |
| Oxton Parkonians 2nd XV | 36 | 17 | Oldershaw 2nd XV |
| Wallasey 2nd XV | 5 | 77 | Wirral 4th XV |
| Saturday, 29 January 2022 |
| Hoylake 2nd XV | 43 | 0 | Wirral 4th XV |
| Oxton Parkonians 2nd XV | 5 | 37 | Wallasey 2nd XV |
| Saturday, 5 February 2022 |
| Hoylake 2nd XV | 34 | 29 | Oldershaw 2nd XV |
| Saturday, 12 February 2022 |
| Wallasey 2nd XV | 13 | 14 | Hoylake 2nd XV |
| Wirral 4th XV | 38 | 0 | Merseyside Police |
| Saturday, 26 February 2022 |
| Merseyside Police | 24 | 15 | Hoylake 2nd XV |
| Saturday, 5 March 2022 |
| Anselmians 3rd XV | 17 | 12 | Oldershaw 2nd XV |
| Saturday, 12 March 2022 |
| Oxton Parkonians 2nd XV | 14 | 74 | Anselmians 3rd XV |
| Saturday, 26 March 2022 |
| Merseyside Police | 61 | 14 | Oxton Parkonians 2nd XV |
| Oldershaw 2nd XV | 17 | 64 | Wirral 4th XV |
| Saturday, 2 April 2022 |
| Oldershaw 2nd XV | 14 | 40 | Hoylake 2nd XV |
| Oxton Parkonians 2nd XV | Away Walkover | Wirral 4th XV |
| Saturday, 9 April 2022 |
| Hoylake 2nd XV | Home Walkover | Oxton Parkonians 2nd XV |
| Oldershaw 2nd XV | Home Walkover | Merseyside Police |
| Saturday, 23 April 2022 |
| Wallasey 2nd XV | 7 | 81 | Anselmians 3rd XV |
| Saturday, 30 April 2022 |
| Merseyside Police | 7 | 46 | Anselmians 3rd XV |