| Saturday, 4 September 2021 |
| Didsbury Toc H 3rd XV | 14 | 71 | Ashton-Under-Lyne 2nd XV |
| Glossop 3rd XV | 26 | 21 | Bury 2nd XV |
| Hope Valley | 30 | 19 | Old Bedians 2nd XV |
| Marple 2nd XV | 33 | 17 | Stockport 3rd XV |
| Saturday, 11 September 2021 |
| Burnage 3rd XV | 38 | 10 | Congleton 2nd XV |
| Bury 2nd XV | 10 | 12 | Ashton-Under-Lyne 2nd XV |
| Stockport 3rd XV | 34 | 10 | Old Bedians 2nd XV |
| Village Spartans | 57 | 5 | Didsbury Toc H 3rd XV |
| Saturday, 18 September 2021 |
| Burnage 3rd XV | 29 | 48 | Hope Valley |
| Glossop 3rd XV | 46 | 20 | Congleton 2nd XV |
| Marple 2nd XV | 25 | 10 | Village Spartans |
| Saturday, 25 September 2021 |
| Hope Valley | Home Walkover | Glossop 3rd XV |
| Marple 2nd XV | 46 | 7 | Didsbury Toc H 3rd XV |
| Stockport 3rd XV | Away Walkover | Burnage 3rd XV |
| Village Spartans | 71 | 20 | Old Bedians 2nd XV |
| Saturday, 2 October 2021 |
| Ashton-Under-Lyne 2nd XV | 12 | 54 | Hope Valley |
| Bury 2nd XV | 13 | 7 | Congleton 2nd XV |
| Glossop 3rd XV | 10 | 25 | Stockport 3rd XV |
| Old Bedians 2nd XV | 20 | 10 | Marple 2nd XV |
| Saturday, 9 October 2021 |
| Bury 2nd XV | 9 | 50 | Burnage 3rd XV |
| Saturday, 16 October 2021 |
| Didsbury Toc H 3rd XV | 33 | 7 | Old Bedians 2nd XV |
| Stockport 3rd XV | 74 | 17 | Ashton-Under-Lyne 2nd XV |
| Village Spartans | 47 | 25 | Burnage 3rd XV |
| Saturday, 23 October 2021 |
| Burnage 3rd XV | 33 | 7 | Marple 2nd XV |
| Bury 2nd XV | 25 | 12 | Stockport 3rd XV |
| Didsbury Toc H 3rd XV | 57 | 0 | Congleton 2nd XV |
| Glossop 3rd XV | 14 | 31 | Village Spartans |
| Saturday, 30 October 2021 |
| Congleton 2nd XV | 0 | 8 | Hope Valley |
| Marple 2nd XV | 31 | 25 | Glossop 3rd XV |
| Old Bedians 2nd XV | 27 | 22 | Burnage 3rd XV |
| Village Spartans | 31 | 26 | Ashton-Under-Lyne 2nd XV |
| Saturday, 13 November 2021 |
| Ashton-Under-Lyne 2nd XV | 31 | 18 | Marple 2nd XV |
| Bury 2nd XV | 14 | 12 | Village Spartans |
| Congleton 2nd XV | 34 | 21 | Stockport 3rd XV |
| Didsbury Toc H 3rd XV | 11 | 24 | Hope Valley |
| Glossop 3rd XV | 26 | 38 | Old Bedians 2nd XV |
| Saturday, 20 November 2021 |
| Ashton-Under-Lyne 2nd XV | 15 | 22 | Old Bedians 2nd XV |
| Burnage 3rd XV | 71 | 0 | Didsbury Toc H 3rd XV |
| Marple 2nd XV | 8 | 7 | Bury 2nd XV |
| Saturday, 27 November 2021 |
| Bury 2nd XV | 34 | 31 | Old Bedians 2nd XV |
| Congleton 2nd XV | 36 | 0 | Village Spartans |
| Didsbury Toc H 3rd XV | 20 | 36 | Stockport 3rd XV |
| Saturday, 4 December 2021 |
| Burnage 3rd XV | 29 | 14 | Ashton-Under-Lyne 2nd XV |
| Marple 2nd XV | 36 | 0 | Congleton 2nd XV |
| Village Spartans | 20 | 29 | Hope Valley |
| Saturday, 11 December 2021 |
| Ashton-Under-Lyne 2nd XV | 27 | 34 | Glossop 3rd XV |
| Hope Valley | 21 | 17 | Marple 2nd XV |
| Stockport 3rd XV | 12 | 10 | Village Spartans |
| Saturday, 8 January 2022 |
| Bury 2nd XV | 8 | 0 | Didsbury Toc H 3rd XV |
| Congleton 2nd XV | 5 | 5 | Glossop 3rd XV |
| Hope Valley | 40 | 7 | Burnage 3rd XV |
| Saturday, 15 January 2022 |
| Burnage 3rd XV | 22 | 24 | Stockport 3rd XV |
| Congleton 2nd XV | 26 | 19 | Ashton-Under-Lyne 2nd XV |
| Didsbury Toc H 3rd XV | 11 | 17 | Marple 2nd XV |
| Hope Valley | 38 | 12 | Glossop 3rd XV |
| Old Bedians 2nd XV | 5 | 19 | Village Spartans |
| Saturday, 22 January 2022 |
| Congleton 2nd XV | 0 | 20 | Bury 2nd XV |
| Hope Valley | Home Walkover | Ashton-Under-Lyne 2nd XV |
| Marple 2nd XV | 24 | 15 | Old Bedians 2nd XV |
| Stockport 3rd XV | 39 | 12 | Glossop 3rd XV |
| Saturday, 29 January 2022 |
| Ashton-Under-Lyne 2nd XV | 19 | 7 | Stockport 3rd XV |
| Burnage 3rd XV | 26 | 12 | Village Spartans |
| Bury 2nd XV | 27 | 17 | Hope Valley |
| Old Bedians 2nd XV | 7 | 14 | Didsbury Toc H 3rd XV |
| Saturday, 5 February 2022 |
| Congleton 2nd XV | 7 | 12 | Old Bedians 2nd XV |
| Glossop 3rd XV | Home Walkover | Burnage 3rd XV |
| Village Spartans | 15 | 27 | Marple 2nd XV |
| Saturday, 12 February 2022 |
| Congleton 2nd XV | Away Walkover | Didsbury Toc H 3rd XV |
| Marple 2nd XV | 13 | 14 | Burnage 3rd XV |
| Stockport 3rd XV | 12 | 0 | Hope Valley |
| Stockport 3rd XV | 5 | 5 | Bury 2nd XV |
| Village Spartans | 48 | 13 | Glossop 3rd XV |
| Saturday, 19 February 2022 |
| Ashton-Under-Lyne 2nd XV | 0 | 5 | Village Spartans |
| Burnage 3rd XV | 38 | 12 | Old Bedians 2nd XV |
| Glossop 3rd XV | 0 | 5 | Marple 2nd XV |
| Hope Valley | 8 | 0 | Congleton 2nd XV |
| Saturday, 26 February 2022 |
| Glossop 3rd XV | 40 | 29 | Didsbury Toc H 3rd XV |
| Hope Valley | 8 | 0 | Bury 2nd XV |
| Saturday, 5 March 2022 |
| Hope Valley | Home Walkover | Didsbury Toc H 3rd XV |
| Marple 2nd XV | 25 | 12 | Ashton-Under-Lyne 2nd XV |
| Old Bedians 2nd XV | Home Walkover | Glossop 3rd XV |
| Stockport 3rd XV | 23 | 22 | Congleton 2nd XV |
| Village Spartans | 26 | 24 | Bury 2nd XV |
| Saturday, 12 March 2022 |
| Bury 2nd XV | 30 | 31 | Marple 2nd XV |
| Didsbury Toc H 3rd XV | Away Walkover | Burnage 3rd XV |
| Hope Valley | 34 | 7 | Stockport 3rd XV |
| Old Bedians 2nd XV | 34 | 50 | Ashton-Under-Lyne 2nd XV |
| Saturday, 19 March 2022 |
| Ashton-Under-Lyne 2nd XV | 14 | 8 | Congleton 2nd XV |
| Didsbury Toc H 3rd XV | 5 | 46 | Bury 2nd XV |
| Saturday, 26 March 2022 |
| Glossop 3rd XV | 13 | 14 | Burnage 3rd XV |
| Old Bedians 2nd XV | Away Walkover | Bury 2nd XV |
| Stockport 3rd XV | 26 | 57 | Didsbury Toc H 3rd XV |
| Village Spartans | 27 | 17 | Congleton 2nd XV |
| Saturday, 2 April 2022 |
| Ashton-Under-Lyne 2nd XV | 29 | 33 | Burnage 3rd XV |
| Congleton 2nd XV | 13 | 5 | Marple 2nd XV |
| Didsbury Toc H 3rd XV | 31 | 15 | Glossop 3rd XV |
| Hope Valley | Home Walkover | Village Spartans |
| Saturday, 9 April 2022 |
| Burnage 3rd XV | 15 | 32 | Bury 2nd XV |
| Glossop 3rd XV | 33 | 39 | Ashton-Under-Lyne 2nd XV |
| Marple 2nd XV | Away Walkover | Hope Valley |
| Old Bedians 2nd XV | Away Walkover | Congleton 2nd XV |
| Village Spartans | 44 | 34 | Stockport 3rd XV |
| Saturday, 23 April 2022 |
| Ashton-Under-Lyne 2nd XV | 46 | 3 | Didsbury Toc H 3rd XV |
| Bury 2nd XV | 63 | 0 | Glossop 3rd XV |
| Old Bedians 2nd XV | 0 | 71 | Hope Valley |
| Stockport 3rd XV | 50 | 66 | Marple 2nd XV |
| Saturday, 30 April 2022 |
| Ashton-Under-Lyne 2nd XV | 46 | 12 | Bury 2nd XV |
| Congleton 2nd XV | 14 | 49 | Burnage 3rd XV |
| Didsbury Toc H 3rd XV | Home Walkover | Village Spartans |
| Old Bedians 2nd XV | 28 | 38 | Stockport 3rd XV |