| Saturday, 16 January 2021 |
| Ellesmere Port 2nd XV | Postponed | Anselmians 2nd XV |
| Hoylake 2nd XV | Postponed | New Brighton 2nd XV |
| Ormskirk 2nd XV | Postponed | Wirral 4th XV |
| Saturday, 23 January 2021 |
| Anselmians 2nd XV | Postponed | Hoylake 2nd XV |
| Birkenhead Park 4th XV | Postponed | Ormskirk 2nd XV |
| Wirral 4th XV | Postponed | Ellesmere Port 2nd XV |
| Saturday, 30 January 2021 |
| Ellesmere Port 2nd XV | Postponed | Birkenhead Park 4th XV |
| Hoylake 2nd XV | Postponed | Wirral 4th XV |
| New Brighton 2nd XV | Postponed | Anselmians 2nd XV |
| Saturday, 6 February 2021 |
| Birkenhead Park 4th XV | Postponed | Hoylake 2nd XV |
| Ormskirk 2nd XV | Postponed | Ellesmere Port 2nd XV |
| Wirral 4th XV | Postponed | New Brighton 2nd XV |
| Saturday, 13 February 2021 |
| Anselmians 2nd XV | Postponed | Wirral 4th XV |
| Hoylake 2nd XV | Postponed | Ormskirk 2nd XV |
| New Brighton 2nd XV | Postponed | Birkenhead Park 4th XV |
| Saturday, 20 February 2021 |
| Birkenhead Park 4th XV | Postponed | Anselmians 2nd XV |
| Ellesmere Port 2nd XV | Postponed | Hoylake 2nd XV |
| Ormskirk 2nd XV | Postponed | New Brighton 2nd XV |
| Saturday, 27 February 2021 |
| Anselmians 2nd XV | Postponed | Ormskirk 2nd XV |
| New Brighton 2nd XV | Postponed | Ellesmere Port 2nd XV |
| Wirral 4th XV | Postponed | Birkenhead Park 4th XV |
| Saturday, 13 March 2021 |
| Ellesmere Port 2nd XV | v | Wirral 4th XV |
| Hoylake 2nd XV | v | Anselmians 2nd XV |
| Ormskirk 2nd XV | v | Birkenhead Park 4th XV |
| Saturday, 20 March 2021 |
| Anselmians 2nd XV | v | New Brighton 2nd XV |
| Birkenhead Park 4th XV | v | Ellesmere Port 2nd XV |
| Wirral 4th XV | v | Hoylake 2nd XV |
| Saturday, 27 March 2021 |
| Ellesmere Port 2nd XV | v | Ormskirk 2nd XV |
| Hoylake 2nd XV | v | Birkenhead Park 4th XV |
| New Brighton 2nd XV | v | Wirral 4th XV |
| Saturday, 10 April 2021 |
| Birkenhead Park 4th XV | v | New Brighton 2nd XV |
| Ormskirk 2nd XV | v | Hoylake 2nd XV |
| Wirral 4th XV | v | Anselmians 2nd XV |
| Saturday, 17 April 2021 |
| Anselmians 2nd XV | v | Birkenhead Park 4th XV |
| Hoylake 2nd XV | v | Ellesmere Port 2nd XV |
| New Brighton 2nd XV | v | Ormskirk 2nd XV |
| Saturday, 24 April 2021 |
| Birkenhead Park 4th XV | v | Wirral 4th XV |
| Ellesmere Port 2nd XV | v | New Brighton 2nd XV |
| Ormskirk 2nd XV | v | Anselmians 2nd XV |
| Saturday, 1 May 2021 |
| Anselmians 2nd XV | v | Ellesmere Port 2nd XV |
| New Brighton 2nd XV | v | Hoylake 2nd XV |
| Wirral 4th XV | v | Ormskirk 2nd XV |