| Saturday, 16 January 2021 |
| Holmes Chapel | Postponed | Knutsford |
| Wythenshawe | Postponed | Macclesfield 4th XV |
| Saturday, 23 January 2021 |
| Hope Valley | Postponed | Village Spartans |
| Macclesfield 4th XV | Postponed | Holmes Chapel |
| Saturday, 30 January 2021 |
| Knutsford | Postponed | Macclesfield 4th XV |
| Wythenshawe | Postponed | Hope Valley |
| Saturday, 6 February 2021 |
| Hope Valley | Postponed | Holmes Chapel |
| Village Spartans | Postponed | Wythenshawe |
| Saturday, 13 February 2021 |
| Holmes Chapel | Postponed | Village Spartans |
| Knutsford | Postponed | Hope Valley |
| Saturday, 20 February 2021 |
| Hope Valley | Postponed | Macclesfield 4th XV |
| Village Spartans | Postponed | Knutsford |
| Wythenshawe | Postponed | Holmes Chapel |
| Saturday, 27 February 2021 |
| Knutsford | Postponed | Wythenshawe |
| Macclesfield 4th XV | Postponed | Village Spartans |
| Saturday, 13 March 2021 |
| Holmes Chapel | v | Macclesfield 4th XV |
| Village Spartans | v | Hope Valley |
| Saturday, 20 March 2021 |
| Hope Valley | v | Wythenshawe |
| Macclesfield 4th XV | v | Knutsford |
| Saturday, 27 March 2021 |
| Holmes Chapel | v | Hope Valley |
| Wythenshawe | v | Village Spartans |
| Saturday, 10 April 2021 |
| Hope Valley | v | Knutsford |
| Village Spartans | v | Holmes Chapel |
| Saturday, 17 April 2021 |
| Holmes Chapel | v | Wythenshawe |
| Knutsford | v | Village Spartans |
| Macclesfield 4th XV | v | Hope Valley |
| Saturday, 24 April 2021 |
| Village Spartans | v | Macclesfield 4th XV |
| Wythenshawe | v | Knutsford |
| Saturday, 1 May 2021 |
| Knutsford | v | Holmes Chapel |
| Macclesfield 4th XV | v | Wythenshawe |