| Saturday, 16 January 2021 |
| Ashton-Under-Lyne 2nd XV | Postponed | Marple 3rd XV |
| Holmes Chapel 2nd XV | Postponed | Didsbury Toc H 3rd XV |
| Old Bedians 2nd XV | Postponed | Heaton Moor 3rd XV |
| Saturday, 23 January 2021 |
| Didsbury Toc H 3rd XV | Postponed | Ashton-Under-Lyne 2nd XV |
| Heaton Moor 3rd XV | Postponed | Holmes Chapel 2nd XV |
| Marple 3rd XV | Postponed | Carrington |
| Saturday, 30 January 2021 |
| Ashton-Under-Lyne 2nd XV | Postponed | Heaton Moor 3rd XV |
| Carrington | Postponed | Didsbury Toc H 3rd XV |
| Holmes Chapel 2nd XV | Postponed | Old Bedians 2nd XV |
| Saturday, 6 February 2021 |
| Didsbury Toc H 3rd XV | Postponed | Marple 3rd XV |
| Heaton Moor 3rd XV | Postponed | Carrington |
| Old Bedians 2nd XV | Postponed | Ashton-Under-Lyne 2nd XV |
| Saturday, 13 February 2021 |
| Ashton-Under-Lyne 2nd XV | Postponed | Holmes Chapel 2nd XV |
| Carrington | Postponed | Old Bedians 2nd XV |
| Marple 3rd XV | Postponed | Heaton Moor 3rd XV |
| Saturday, 20 February 2021 |
| Heaton Moor 3rd XV | Postponed | Didsbury Toc H 3rd XV |
| Holmes Chapel 2nd XV | Postponed | Carrington |
| Old Bedians 2nd XV | Postponed | Marple 3rd XV |
| Saturday, 27 February 2021 |
| Carrington | Postponed | Ashton-Under-Lyne 2nd XV |
| Didsbury Toc H 3rd XV | Postponed | Old Bedians 2nd XV |
| Marple 3rd XV | Postponed | Holmes Chapel 2nd XV |
| Saturday, 13 March 2021 |
| Ashton-Under-Lyne 2nd XV | v | Didsbury Toc H 3rd XV |
| Carrington | v | Marple 3rd XV |
| Holmes Chapel 2nd XV | v | Heaton Moor 3rd XV |
| Saturday, 20 March 2021 |
| Didsbury Toc H 3rd XV | v | Carrington |
| Heaton Moor 3rd XV | v | Ashton-Under-Lyne 2nd XV |
| Old Bedians 2nd XV | v | Holmes Chapel 2nd XV |
| Saturday, 27 March 2021 |
| Ashton-Under-Lyne 2nd XV | v | Old Bedians 2nd XV |
| Carrington | v | Heaton Moor 3rd XV |
| Marple 3rd XV | v | Didsbury Toc H 3rd XV |
| Saturday, 10 April 2021 |
| Heaton Moor 3rd XV | v | Marple 3rd XV |
| Holmes Chapel 2nd XV | v | Ashton-Under-Lyne 2nd XV |
| Old Bedians 2nd XV | v | Carrington |
| Saturday, 17 April 2021 |
| Carrington | v | Holmes Chapel 2nd XV |
| Didsbury Toc H 3rd XV | v | Heaton Moor 3rd XV |
| Marple 3rd XV | v | Old Bedians 2nd XV |
| Saturday, 24 April 2021 |
| Ashton-Under-Lyne 2nd XV | v | Carrington |
| Holmes Chapel 2nd XV | v | Marple 3rd XV |
| Old Bedians 2nd XV | v | Didsbury Toc H 3rd XV |
| Saturday, 1 May 2021 |
| Didsbury Toc H 3rd XV | v | Holmes Chapel 2nd XV |
| Heaton Moor 3rd XV | v | Old Bedians 2nd XV |
| Marple 3rd XV | v | Ashton-Under-Lyne 2nd XV |