| Saturday, 16 January 2021 |
| Ormskirk 3rd XV | Postponed | Liverpool St Helens 3rd XV |
| Sefton 3rd XV | Postponed | Moore 2nd XV |
| Widnes 3rd XV | Postponed | New Brighton 3rd XV |
| Saturday, 23 January 2021 |
| Liverpool St Helens 3rd XV | Postponed | Sefton 3rd XV |
| Moore 2nd XV | Postponed | Widnes 3rd XV |
| West Park (St Helens) 3rd XV | Postponed | Ormskirk 3rd XV |
| Saturday, 30 January 2021 |
| New Brighton 3rd XV | Postponed | Moore 2nd XV |
| Sefton 3rd XV | Postponed | West Park (St Helens) 3rd XV |
| Widnes 3rd XV | Postponed | Liverpool St Helens 3rd XV |
| Saturday, 6 February 2021 |
| Liverpool St Helens 3rd XV | Postponed | New Brighton 3rd XV |
| Ormskirk 3rd XV | Postponed | Sefton 3rd XV |
| West Park (St Helens) 3rd XV | Postponed | Widnes 3rd XV |
| Saturday, 13 February 2021 |
| Moore 2nd XV | Postponed | Liverpool St Helens 3rd XV |
| New Brighton 3rd XV | Postponed | West Park (St Helens) 3rd XV |
| Widnes 3rd XV | Postponed | Ormskirk 3rd XV |
| Saturday, 20 February 2021 |
| Ormskirk 3rd XV | Postponed | New Brighton 3rd XV |
| Sefton 3rd XV | Postponed | Widnes 3rd XV |
| West Park (St Helens) 3rd XV | Postponed | Moore 2nd XV |
| Saturday, 27 February 2021 |
| Liverpool St Helens 3rd XV | Postponed | West Park (St Helens) 3rd XV |
| Moore 2nd XV | Postponed | Ormskirk 3rd XV |
| New Brighton 3rd XV | Postponed | Sefton 3rd XV |
| Saturday, 13 March 2021 |
| Ormskirk 3rd XV | v | West Park (St Helens) 3rd XV |
| Sefton 3rd XV | v | Liverpool St Helens 3rd XV |
| Widnes 3rd XV | v | Moore 2nd XV |
| Saturday, 20 March 2021 |
| Liverpool St Helens 3rd XV | v | Widnes 3rd XV |
| Moore 2nd XV | v | New Brighton 3rd XV |
| West Park (St Helens) 3rd XV | v | Sefton 3rd XV |
| Saturday, 27 March 2021 |
| New Brighton 3rd XV | v | Liverpool St Helens 3rd XV |
| Sefton 3rd XV | v | Ormskirk 3rd XV |
| Widnes 3rd XV | v | West Park (St Helens) 3rd XV |
| Saturday, 10 April 2021 |
| Liverpool St Helens 3rd XV | v | Moore 2nd XV |
| Ormskirk 3rd XV | v | Widnes 3rd XV |
| West Park (St Helens) 3rd XV | v | New Brighton 3rd XV |
| Saturday, 17 April 2021 |
| Moore 2nd XV | v | West Park (St Helens) 3rd XV |
| New Brighton 3rd XV | v | Ormskirk 3rd XV |
| Widnes 3rd XV | v | Sefton 3rd XV |
| Saturday, 24 April 2021 |
| Ormskirk 3rd XV | v | Moore 2nd XV |
| Sefton 3rd XV | v | New Brighton 3rd XV |
| West Park (St Helens) 3rd XV | v | Liverpool St Helens 3rd XV |
| Saturday, 1 May 2021 |
| Liverpool St Helens 3rd XV | v | Ormskirk 3rd XV |
| Moore 2nd XV | v | Sefton 3rd XV |
| New Brighton 3rd XV | v | Widnes 3rd XV |