| Saturday, 16 January 2021 |
| Christleton | Postponed | Mossley Hill 2nd XV |
| Port Sunlight 2nd XV | Postponed | Oxton Parkonians 2nd XV |
| Prenton 2nd XV | Postponed | Oldershaw 2nd XV |
| Saturday, 23 January 2021 |
| Mossley Hill 2nd XV | Postponed | Merseyside Police |
| Oldershaw 2nd XV | Postponed | Christleton |
| Oxton Parkonians 2nd XV | Postponed | Prenton 2nd XV |
| Saturday, 30 January 2021 |
| Christleton | Postponed | Oxton Parkonians 2nd XV |
| Merseyside Police | Postponed | Oldershaw 2nd XV |
| Prenton 2nd XV | Postponed | Port Sunlight 2nd XV |
| Saturday, 6 February 2021 |
| Oldershaw 2nd XV | Postponed | Mossley Hill 2nd XV |
| Oxton Parkonians 2nd XV | Postponed | Merseyside Police |
| Port Sunlight 2nd XV | Postponed | Christleton |
| Saturday, 13 February 2021 |
| Christleton | Postponed | Prenton 2nd XV |
| Merseyside Police | Postponed | Port Sunlight 2nd XV |
| Mossley Hill 2nd XV | Postponed | Oxton Parkonians 2nd XV |
| Saturday, 20 February 2021 |
| Oxton Parkonians 2nd XV | Postponed | Oldershaw 2nd XV |
| Port Sunlight 2nd XV | Postponed | Mossley Hill 2nd XV |
| Prenton 2nd XV | Postponed | Merseyside Police |
| Saturday, 27 February 2021 |
| Merseyside Police | Postponed | Christleton |
| Mossley Hill 2nd XV | Postponed | Prenton 2nd XV |
| Oldershaw 2nd XV | Postponed | Port Sunlight 2nd XV |
| Saturday, 13 March 2021 |
| Christleton | v | Oldershaw 2nd XV |
| Merseyside Police | v | Mossley Hill 2nd XV |
| Prenton 2nd XV | v | Oxton Parkonians 2nd XV |
| Saturday, 20 March 2021 |
| Oldershaw 2nd XV | v | Merseyside Police |
| Oxton Parkonians 2nd XV | v | Christleton |
| Port Sunlight 2nd XV | v | Prenton 2nd XV |
| Saturday, 27 March 2021 |
| Christleton | v | Port Sunlight 2nd XV |
| Merseyside Police | v | Oxton Parkonians 2nd XV |
| Mossley Hill 2nd XV | v | Oldershaw 2nd XV |
| Saturday, 10 April 2021 |
| Oxton Parkonians 2nd XV | v | Mossley Hill 2nd XV |
| Port Sunlight 2nd XV | v | Merseyside Police |
| Prenton 2nd XV | v | Christleton |
| Saturday, 17 April 2021 |
| Merseyside Police | v | Prenton 2nd XV |
| Mossley Hill 2nd XV | v | Port Sunlight 2nd XV |
| Oldershaw 2nd XV | v | Oxton Parkonians 2nd XV |
| Saturday, 24 April 2021 |
| Christleton | v | Merseyside Police |
| Port Sunlight 2nd XV | v | Oldershaw 2nd XV |
| Prenton 2nd XV | v | Mossley Hill 2nd XV |
| Saturday, 1 May 2021 |
| Mossley Hill 2nd XV | v | Christleton |
| Oldershaw 2nd XV | v | Prenton 2nd XV |
| Oxton Parkonians 2nd XV | v | Port Sunlight 2nd XV |