| Saturday, 23 January 2021 |
| Warrington 2nd XV | Postponed | Rochdale 2nd XV |
| Winnington Park 2nd XV | Postponed | De La Salle (Salford) 2nd XV |
| Saturday, 30 January 2021 |
| De La Salle (Salford) 2nd XV | Postponed | Sedgley Park 3rd XV |
| Rochdale 2nd XV | Postponed | Winnington Park 2nd XV |
| Saturday, 13 February 2021 |
| Sedgley Park 3rd XV | Postponed | Rochdale 2nd XV |
| Winnington Park 2nd XV | Postponed | Warrington 2nd XV |
| Saturday, 20 February 2021 |
| Rochdale 2nd XV | Postponed | De La Salle (Salford) 2nd XV |
| Warrington 2nd XV | Postponed | Sedgley Park 3rd XV |
| Saturday, 6 March 2021 |
| De La Salle (Salford) 2nd XV | Postponed | Warrington 2nd XV |
| Sedgley Park 3rd XV | Postponed | Winnington Park 2nd XV |
| Saturday, 13 March 2021 |
| Sedgley Park 3rd XV | v | De La Salle (Salford) 2nd XV |
| Winnington Park 2nd XV | v | Rochdale 2nd XV |
| Saturday, 27 March 2021 |
| Rochdale 2nd XV | v | Sedgley Park 3rd XV |
| Warrington 2nd XV | v | Winnington Park 2nd XV |
| Saturday, 10 April 2021 |
| De La Salle (Salford) 2nd XV | v | Rochdale 2nd XV |
| Sedgley Park 3rd XV | v | Warrington 2nd XV |
| Saturday, 17 April 2021 |
| Warrington 2nd XV | v | De La Salle (Salford) 2nd XV |
| Winnington Park 2nd XV | v | Sedgley Park 3rd XV |
| Saturday, 24 April 2021 |
| De La Salle (Salford) 2nd XV | v | Winnington Park 2nd XV |
| Rochdale 2nd XV | v | Warrington 2nd XV |