| Saturday, 16 January 2021 |
| Helsby | Postponed | Wallasey |
| Oldershaw | Postponed | Prenton |
| Oxton Parkonians | Postponed | Port Sunlight |
| Saturday, 23 January 2021 |
| Capenhurst | Postponed | Helsby |
| Prenton | Postponed | Oxton Parkonians |
| Wallasey | Postponed | Oldershaw |
| Saturday, 30 January 2021 |
| Oldershaw | Postponed | Capenhurst |
| Oxton Parkonians | Postponed | Wallasey |
| Port Sunlight | Postponed | Prenton |
| Saturday, 6 February 2021 |
| Capenhurst | Postponed | Oxton Parkonians |
| Helsby | Postponed | Oldershaw |
| Wallasey | Postponed | Port Sunlight |
| Saturday, 13 February 2021 |
| Oxton Parkonians | Postponed | Helsby |
| Port Sunlight | Postponed | Capenhurst |
| Prenton | Postponed | Wallasey |
| Saturday, 20 February 2021 |
| Capenhurst | Postponed | Prenton |
| Helsby | Postponed | Port Sunlight |
| Oldershaw | Postponed | Oxton Parkonians |
| Saturday, 27 February 2021 |
| Port Sunlight | Postponed | Oldershaw |
| Prenton | Postponed | Helsby |
| Wallasey | Postponed | Capenhurst |
| Saturday, 13 March 2021 |
| Helsby | v | Capenhurst |
| Oldershaw | v | Wallasey |
| Oxton Parkonians | v | Prenton |
| Saturday, 20 March 2021 |
| Capenhurst | v | Oldershaw |
| Prenton | v | Port Sunlight |
| Wallasey | v | Oxton Parkonians |
| Saturday, 27 March 2021 |
| Oldershaw | v | Helsby |
| Oxton Parkonians | v | Capenhurst |
| Port Sunlight | v | Wallasey |
| Saturday, 10 April 2021 |
| Capenhurst | v | Port Sunlight |
| Helsby | v | Oxton Parkonians |
| Wallasey | v | Prenton |
| Saturday, 17 April 2021 |
| Oxton Parkonians | v | Oldershaw |
| Port Sunlight | v | Helsby |
| Prenton | v | Capenhurst |
| Saturday, 24 April 2021 |
| Capenhurst | v | Wallasey |
| Helsby | v | Prenton |
| Oldershaw | v | Port Sunlight |
| Saturday, 1 May 2021 |
| Port Sunlight | v | Oxton Parkonians |
| Prenton | v | Oldershaw |
| Wallasey | v | Helsby |