| Saturday, 16 January 2021 |
| Eagle | Postponed | Mossley Hill |
| Newton-le-Willows | Postponed | St Edward's O.B. |
| Saturday, 23 January 2021 |
| Moore | Postponed | Crosby St Mary's |
| Mossley Hill | Postponed | Newton-le-Willows |
| Saturday, 30 January 2021 |
| Eagle | Postponed | Moore |
| St Edward's O.B. | Postponed | Mossley Hill |
| Saturday, 6 February 2021 |
| Crosby St Mary's | Postponed | Eagle |
| Moore | Postponed | Newton-le-Willows |
| Saturday, 13 February 2021 |
| Newton-le-Willows | Postponed | Crosby St Mary's |
| St Edward's O.B. | Postponed | Moore |
| Saturday, 20 February 2021 |
| Crosby St Mary's | Postponed | St Edward's O.B. |
| Eagle | Postponed | Newton-le-Willows |
| Moore | Postponed | Mossley Hill |
| Saturday, 27 February 2021 |
| Mossley Hill | Postponed | Crosby St Mary's |
| St Edward's O.B. | Postponed | Eagle |
| Saturday, 13 March 2021 |
| Crosby St Mary's | v | Moore |
| Newton-le-Willows | v | Mossley Hill |
| Saturday, 20 March 2021 |
| Moore | v | Eagle |
| Mossley Hill | v | St Edward's O.B. |
| Saturday, 27 March 2021 |
| Eagle | v | Crosby St Mary's |
| Newton-le-Willows | v | Moore |
| Saturday, 10 April 2021 |
| Crosby St Mary's | v | Newton-le-Willows |
| Moore | v | St Edward's O.B. |
| Saturday, 17 April 2021 |
| Mossley Hill | v | Moore |
| Newton-le-Willows | v | Eagle |
| St Edward's O.B. | v | Crosby St Mary's |
| Saturday, 24 April 2021 |
| Crosby St Mary's | v | Mossley Hill |
| Eagle | v | St Edward's O.B. |
| Saturday, 1 May 2021 |
| Mossley Hill | v | Eagle |
| St Edward's O.B. | v | Newton-le-Willows |