| Saturday, 23 January 2021 |
| Chester 3rd XV | Postponed | Macclesfield 2nd XV |
| Firwood Waterloo 2nd XV | Postponed | Northwich 2nd XV |
| Sandbach 2nd XV | Postponed | Birkenhead Park Wanderers (2nd XV) |
| Wirral 2nd XV | Postponed | Lymm 2nd XV |
| Saturday, 30 January 2021 |
| Firwood Waterloo 2nd XV | Postponed | Sandbach 2nd XV |
| Lymm 2nd XV | Postponed | Birkenhead Park Wanderers (2nd XV) |
| Macclesfield 2nd XV | Postponed | Wirral 2nd XV |
| Northwich 2nd XV | Postponed | Chester 3rd XV |
| Saturday, 6 February 2021 |
| Birkenhead Park Wanderers (2nd XV) | Postponed | Wirral 2nd XV |
| Lymm 2nd XV | Postponed | Chester 3rd XV |
| Macclesfield 2nd XV | Postponed | Firwood Waterloo 2nd XV |
| Sandbach 2nd XV | Postponed | Northwich 2nd XV |
| Saturday, 13 February 2021 |
| Birkenhead Park Wanderers (2nd XV) | Postponed | Macclesfield 2nd XV |
| Chester 3rd XV | Postponed | Firwood Waterloo 2nd XV |
| Sandbach 2nd XV | Postponed | Lymm 2nd XV |
| Wirral 2nd XV | Postponed | Northwich 2nd XV |
| Saturday, 20 February 2021 |
| Chester 3rd XV | Postponed | Sandbach 2nd XV |
| Firwood Waterloo 2nd XV | Postponed | Wirral 2nd XV |
| Macclesfield 2nd XV | Postponed | Lymm 2nd XV |
| Northwich 2nd XV | Postponed | Birkenhead Park Wanderers (2nd XV) |
| Saturday, 27 February 2021 |
| Birkenhead Park Wanderers (2nd XV) | Postponed | Firwood Waterloo 2nd XV |
| Lymm 2nd XV | Postponed | Northwich 2nd XV |
| Sandbach 2nd XV | Postponed | Macclesfield 2nd XV |
| Wirral 2nd XV | Postponed | Chester 3rd XV |
| Saturday, 6 March 2021 |
| Chester 3rd XV | Postponed | Birkenhead Park Wanderers (2nd XV) |
| Firwood Waterloo 2nd XV | Postponed | Lymm 2nd XV |
| Northwich 2nd XV | Postponed | Macclesfield 2nd XV |
| Wirral 2nd XV | Postponed | Sandbach 2nd XV |
| Saturday, 13 March 2021 |
| Birkenhead Park Wanderers (2nd XV) | v | Sandbach 2nd XV |
| Lymm 2nd XV | v | Wirral 2nd XV |
| Macclesfield 2nd XV | v | Chester 3rd XV |
| Northwich 2nd XV | v | Firwood Waterloo 2nd XV |
| Saturday, 27 March 2021 |
| Birkenhead Park Wanderers (2nd XV) | v | Lymm 2nd XV |
| Chester 3rd XV | v | Northwich 2nd XV |
| Sandbach 2nd XV | v | Firwood Waterloo 2nd XV |
| Wirral 2nd XV | v | Macclesfield 2nd XV |
| Saturday, 10 April 2021 |
| Firwood Waterloo 2nd XV | v | Chester 3rd XV |
| Lymm 2nd XV | v | Sandbach 2nd XV |
| Macclesfield 2nd XV | v | Birkenhead Park Wanderers (2nd XV) |
| Northwich 2nd XV | v | Wirral 2nd XV |
| Saturday, 17 April 2021 |
| Birkenhead Park Wanderers (2nd XV) | v | Northwich 2nd XV |
| Lymm 2nd XV | v | Macclesfield 2nd XV |
| Sandbach 2nd XV | v | Chester 3rd XV |
| Wirral 2nd XV | v | Firwood Waterloo 2nd XV |
| Saturday, 24 April 2021 |
| Chester 3rd XV | v | Wirral 2nd XV |
| Firwood Waterloo 2nd XV | v | Birkenhead Park Wanderers (2nd XV) |
| Macclesfield 2nd XV | v | Sandbach 2nd XV |
| Northwich 2nd XV | v | Lymm 2nd XV |
| Saturday, 8 May 2021 |
| Birkenhead Park Wanderers (2nd XV) | v | Chester 3rd XV |
| Lymm 2nd XV | v | Firwood Waterloo 2nd XV |
| Macclesfield 2nd XV | v | Northwich 2nd XV |
| Sandbach 2nd XV | v | Wirral 2nd XV |
| Saturday, 15 May 2021 |
| Chester 3rd XV | v | Lymm 2nd XV |
| Firwood Waterloo 2nd XV | v | Macclesfield 2nd XV |
| Northwich 2nd XV | v | Sandbach 2nd XV |
| Wirral 2nd XV | v | Birkenhead Park Wanderers (2nd XV) |