| Saturday, 1 September 2018 |
| Bowdon 2nd XV | 31 | 31 | Didsbury Toc H 2nd XV |
| Crewe & Nantwich 2nd XV | 14 | 24 | Liverpool Collegiate 2nd XV |
| Holmes Chapel | 20 | 19 | Chester 3rd XV |
| Northwich 2nd XV | 66 | 5 | Winnington Park 2nd XV |
| Widnes 2nd XV | Home Walkover | Wirral 3rd XV |
| Saturday, 8 September 2018 |
| Crewe & Nantwich 2nd XV | 31 | 24 | Northwich 2nd XV |
| Didsbury Toc H 2nd XV | 19 | 10 | Widnes 2nd XV |
| Liverpool Collegiate 2nd XV | 19 | 31 | Chester 3rd XV |
| Liverpool St Helens 2nd XV | 18 | 5 | Holmes Chapel |
| Winnington Park 2nd XV | 12 | 15 | Helsby |
| Saturday, 15 September 2018 |
| Bowdon 2nd XV | 96 | 0 | Winnington Park 2nd XV |
| Chester 3rd XV | 32 | 21 | Liverpool St Helens 2nd XV |
| Helsby | 45 | 0 | Crewe & Nantwich 2nd XV |
| Holmes Chapel | 16 | 12 | Wirral 3rd XV |
| Northwich 2nd XV | 17 | 38 | Liverpool Collegiate 2nd XV |
| Saturday, 22 September 2018 |
| Crewe & Nantwich 2nd XV | 29 | 10 | Bowdon 2nd XV |
| Didsbury Toc H 2nd XV | 10 | 21 | Holmes Chapel |
| Liverpool Collegiate 2nd XV | 24 | 17 | Liverpool St Helens 2nd XV |
| Northwich 2nd XV | 17 | 20 | Helsby |
| Winnington Park 2nd XV | 19 | 27 | Widnes 2nd XV |
| Wirral 3rd XV | 0 | 69 | Chester 3rd XV |
| Saturday, 29 September 2018 |
| Bowdon 2nd XV | 26 | 26 | Northwich 2nd XV |
| Chester 3rd XV | 41 | 19 | Didsbury Toc H 2nd XV |
| Helsby | 35 | 10 | Liverpool Collegiate 2nd XV |
| Liverpool St Helens 2nd XV | 60 | 13 | Wirral 3rd XV |
| Widnes 2nd XV | 62 | 14 | Crewe & Nantwich 2nd XV |
| Saturday, 13 October 2018 |
| Didsbury Toc H 2nd XV | 34 | 26 | Liverpool St Helens 2nd XV |
| Helsby | 15 | 43 | Bowdon 2nd XV |
| Liverpool Collegiate 2nd XV | Home Walkover | Wirral 3rd XV |
| Northwich 2nd XV | 48 | 19 | Widnes 2nd XV |
| Winnington Park 2nd XV | 14 | 31 | Holmes Chapel |
| Saturday, 20 October 2018 |
| Bowdon 2nd XV | 90 | 14 | Liverpool Collegiate 2nd XV |
| Chester 3rd XV | 51 | 12 | Winnington Park 2nd XV |
| Holmes Chapel | 21 | 14 | Crewe & Nantwich 2nd XV |
| Widnes 2nd XV | 16 | 11 | Helsby |
| Wirral 3rd XV | 30 | 27 | Didsbury Toc H 2nd XV |
| Saturday, 27 October 2018 |
| Bowdon 2nd XV | 31 | 17 | Widnes 2nd XV |
| Crewe & Nantwich 2nd XV | 12 | 30 | Chester 3rd XV |
| Liverpool Collegiate 2nd XV | 35 | 34 | Didsbury Toc H 2nd XV |
| Northwich 2nd XV | 21 | 26 | Holmes Chapel |
| Winnington Park 2nd XV | 20 | 45 | Liverpool St Helens 2nd XV |
| Saturday, 3 November 2018 |
| Chester 3rd XV | 24 | 24 | Northwich 2nd XV |
| Holmes Chapel | 19 | 8 | Helsby |
| Liverpool St Helens 2nd XV | 109 | 0 | Crewe & Nantwich 2nd XV |
| Widnes 2nd XV | 29 | 30 | Liverpool Collegiate 2nd XV |
| Wirral 3rd XV | 33 | 56 | Winnington Park 2nd XV |
| Saturday, 17 November 2018 |
| Bowdon 2nd XV | 17 | 15 | Holmes Chapel |
| Crewe & Nantwich 2nd XV | 33 | 12 | Wirral 3rd XV |
| Helsby | 12 | 5 | Chester 3rd XV |
| Northwich 2nd XV | 14 | 38 | Liverpool St Helens 2nd XV |
| Winnington Park 2nd XV | 41 | 43 | Didsbury Toc H 2nd XV |
| Saturday, 24 November 2018 |
| Chester 3rd XV | 73 | 5 | Bowdon 2nd XV |
| Didsbury Toc H 2nd XV | 8 | 0 | Crewe & Nantwich 2nd XV |
| Holmes Chapel | 12 | 10 | Widnes 2nd XV |
| Liverpool St Helens 2nd XV | 20 | 5 | Helsby |
| Wirral 3rd XV | 14 | 55 | Northwich 2nd XV |
| Saturday, 1 December 2018 |
| Bowdon 2nd XV | 17 | 7 | Liverpool St Helens 2nd XV |
| Helsby | 73 | 17 | Wirral 3rd XV |
| Liverpool Collegiate 2nd XV | 67 | 11 | Winnington Park 2nd XV |
| Northwich 2nd XV | 14 | 12 | Didsbury Toc H 2nd XV |
| Widnes 2nd XV | 7 | 7 | Chester 3rd XV |
| Saturday, 8 December 2018 |
| Didsbury Toc H 2nd XV | 12 | 22 | Helsby |
| Liverpool Collegiate 2nd XV | 5 | 14 | Holmes Chapel |
| Liverpool St Helens 2nd XV | 7 | 20 | Widnes 2nd XV |
| Winnington Park 2nd XV | 8 | 0 | Crewe & Nantwich 2nd XV |
| Wirral 3rd XV | 15 | 41 | Bowdon 2nd XV |
| Saturday, 15 December 2018 |
| Chester 3rd XV | 18 | 10 | Liverpool Collegiate 2nd XV |
| Helsby | 32 | 12 | Winnington Park 2nd XV |
| Holmes Chapel | 6 | 6 | Liverpool St Helens 2nd XV |
| Northwich 2nd XV | 8 | 0 | Crewe & Nantwich 2nd XV |
| Widnes 2nd XV | 36 | 5 | Didsbury Toc H 2nd XV |
| Saturday, 5 January 2019 |
| Crewe & Nantwich 2nd XV | 8 | 47 | Helsby |
| Liverpool Collegiate 2nd XV | 53 | 33 | Northwich 2nd XV |
| Liverpool St Helens 2nd XV | 7 | 15 | Chester 3rd XV |
| Winnington Park 2nd XV | 10 | 83 | Bowdon 2nd XV |
| Wirral 3rd XV | 15 | 44 | Holmes Chapel |
| Saturday, 12 January 2019 |
| Bowdon 2nd XV | 25 | 22 | Crewe & Nantwich 2nd XV |
| Chester 3rd XV | 53 | 5 | Wirral 3rd XV |
| Helsby | 58 | 17 | Northwich 2nd XV |
| Holmes Chapel | 22 | 7 | Didsbury Toc H 2nd XV |
| Liverpool St Helens 2nd XV | 28 | 6 | Liverpool Collegiate 2nd XV |
| Widnes 2nd XV | 52 | 12 | Winnington Park 2nd XV |
| Saturday, 19 January 2019 |
| Crewe & Nantwich 2nd XV | 33 | 14 | Widnes 2nd XV |
| Didsbury Toc H 2nd XV | 17 | 27 | Chester 3rd XV |
| Liverpool Collegiate 2nd XV | 12 | 10 | Helsby |
| Northwich 2nd XV | 21 | 41 | Bowdon 2nd XV |
| Wirral 3rd XV | 19 | 38 | Liverpool St Helens 2nd XV |
| Saturday, 26 January 2019 |
| Bowdon 2nd XV | 17 | 22 | Helsby |
| Holmes Chapel | 67 | 0 | Winnington Park 2nd XV |
| Liverpool Collegiate 2nd XV | 25 | 21 | Wirral 3rd XV |
| Liverpool St Helens 2nd XV | 22 | 14 | Didsbury Toc H 2nd XV |
| Widnes 2nd XV | 24 | 17 | Northwich 2nd XV |
| Saturday, 9 February 2019 |
| Crewe & Nantwich 2nd XV | 25 | 33 | Holmes Chapel |
| Didsbury Toc H 2nd XV | 61 | 38 | Wirral 3rd XV |
| Helsby | 10 | 21 | Widnes 2nd XV |
| Winnington Park 2nd XV | 27 | 12 | Chester 3rd XV |
| Saturday, 16 February 2019 |
| Chester 3rd XV | 60 | 24 | Crewe & Nantwich 2nd XV |
| Didsbury Toc H 2nd XV | 12 | 5 | Liverpool Collegiate 2nd XV |
| Holmes Chapel | 40 | 22 | Northwich 2nd XV |
| Liverpool St Helens 2nd XV | 74 | 10 | Winnington Park 2nd XV |
| Widnes 2nd XV | 22 | 26 | Bowdon 2nd XV |
| Saturday, 23 February 2019 |
| Liverpool Collegiate 2nd XV | 36 | 12 | Crewe & Nantwich 2nd XV |
| Saturday, 2 March 2019 |
| Crewe & Nantwich 2nd XV | 10 | 7 | Liverpool St Helens 2nd XV |
| Helsby | 12 | 0 | Holmes Chapel |
| Liverpool Collegiate 2nd XV | 19 | 36 | Widnes 2nd XV |
| Northwich 2nd XV | 28 | 38 | Chester 3rd XV |
| Winnington Park 2nd XV | 10 | 8 | Wirral 3rd XV |
| Saturday, 9 March 2019 |
| Chester 3rd XV | 33 | 19 | Helsby |
| Holmes Chapel | 22 | 24 | Bowdon 2nd XV |
| Liverpool St Helens 2nd XV | 10 | 34 | Northwich 2nd XV |
| Wirral 3rd XV | 17 | 15 | Crewe & Nantwich 2nd XV |
| Saturday, 23 March 2019 |
| Crewe & Nantwich 2nd XV | 27 | 24 | Didsbury Toc H 2nd XV |
| Helsby | 21 | 12 | Liverpool St Helens 2nd XV |
| Northwich 2nd XV | 29 | 24 | Wirral 3rd XV |
| Widnes 2nd XV | 40 | 7 | Holmes Chapel |
| Saturday, 30 March 2019 |
| Didsbury Toc H 2nd XV | 21 | 38 | Northwich 2nd XV |
| Liverpool St Helens 2nd XV | 24 | 14 | Bowdon 2nd XV |
| Winnington Park 2nd XV | 47 | 17 | Liverpool Collegiate 2nd XV |
| Wirral 3rd XV | 39 | 17 | Helsby |
| Saturday, 6 April 2019 |
| Bowdon 2nd XV | 85 | 7 | Wirral 3rd XV |
| Crewe & Nantwich 2nd XV | 52 | 25 | Winnington Park 2nd XV |
| Helsby | 40 | 54 | Didsbury Toc H 2nd XV |
| Holmes Chapel | 24 | 20 | Liverpool Collegiate 2nd XV |
| Widnes 2nd XV | Home Walkover | Liverpool St Helens 2nd XV |
| Saturday, 13 April 2019 |
| Chester 3rd XV | 41 | 17 | Holmes Chapel |
| Didsbury Toc H 2nd XV | 18 | 38 | Bowdon 2nd XV |
| Widnes 2nd XV | Home Walkover | Wirral 3rd XV |
| Winnington Park 2nd XV | 22 | 55 | Northwich 2nd XV |
| Saturday, 20 April 2019 |
| Bowdon 2nd XV | 19 | 12 | Chester 3rd XV |
| Saturday, 27 April 2019 |
| Chester 3rd XV | Home Walkover | Widnes 2nd XV |
| Didsbury Toc H 2nd XV | Home Walkover | Winnington Park 2nd XV |
| Liverpool Collegiate 2nd XV | Away Walkover | Bowdon 2nd XV |