| Saturday, 1 September 2018 |
| Birkenhead Park Wanderers (2nd XV) | 22 | 17 | Warrington 2nd XV |
| Broughton Park 2nd XV | Home Walkover | Liverpool University Veterinarians |
| Burnage 2nd XV | 36 | 19 | Altrincham Kersal Cougars (2nd XV) |
| Fylde Saracens (3rd XV) | 62 | 22 | Sedgley Park 3rd XV |
| Glossop 2nd XV | 43 | 7 | Penrith A XV |
| Kirkby Lonsdale 2nd XV | 7 | 57 | Sandbach 2nd XV |
| Saturday, 8 September 2018 |
| Altrincham Kersal Cougars (2nd XV) | 35 | 14 | Fylde Saracens (3rd XV) |
| Birkenhead Park Wanderers (2nd XV) | 58 | 5 | Sedgley Park 3rd XV |
| Broughton Park 2nd XV | 18 | 19 | Kirkby Lonsdale 2nd XV |
| Liverpool University Veterinarians | 12 | 60 | Warrington 2nd XV |
| Penrith A XV | 60 | 40 | Burnage 2nd XV |
| Sandbach 2nd XV | 47 | 13 | Glossop 2nd XV |
| Saturday, 15 September 2018 |
| Burnage 2nd XV | 22 | 29 | Sandbach 2nd XV |
| Fylde Saracens (3rd XV) | 33 | 10 | Penrith A XV |
| Glossop 2nd XV | 35 | 8 | Broughton Park 2nd XV |
| Kirkby Lonsdale 2nd XV | 14 | 22 | Warrington 2nd XV |
| Liverpool University Veterinarians | 28 | 51 | Birkenhead Park Wanderers (2nd XV) |
| Sedgley Park 3rd XV | 32 | 5 | Altrincham Kersal Cougars (2nd XV) |
| Saturday, 22 September 2018 |
| Birkenhead Park Wanderers (2nd XV) | 128 | 0 | Altrincham Kersal Cougars (2nd XV) |
| Broughton Park 2nd XV | 31 | 62 | Burnage 2nd XV |
| Glossop 2nd XV | 19 | 33 | Warrington 2nd XV |
| Liverpool University Veterinarians | 49 | 19 | Kirkby Lonsdale 2nd XV |
| Penrith A XV | 105 | 0 | Sedgley Park 3rd XV |
| Sandbach 2nd XV | 67 | 14 | Fylde Saracens (3rd XV) |
| Saturday, 29 September 2018 |
| Altrincham Kersal Cougars (2nd XV) | 47 | 10 | Penrith A XV |
| Burnage 2nd XV | 7 | 26 | Warrington 2nd XV |
| Fylde Saracens (3rd XV) | 53 | 17 | Broughton Park 2nd XV |
| Glossop 2nd XV | 20 | 50 | Liverpool University Veterinarians |
| Kirkby Lonsdale 2nd XV | 10 | 16 | Birkenhead Park Wanderers (2nd XV) |
| Sedgley Park 3rd XV | 0 | 95 | Sandbach 2nd XV |
| Saturday, 13 October 2018 |
| Birkenhead Park Wanderers (2nd XV) | 29 | 17 | Penrith A XV |
| Broughton Park 2nd XV | 50 | 0 | Sedgley Park 3rd XV |
| Kirkby Lonsdale 2nd XV | 36 | 6 | Glossop 2nd XV |
| Liverpool University Veterinarians | 15 | 29 | Burnage 2nd XV |
| Sandbach 2nd XV | 57 | 12 | Altrincham Kersal Cougars (2nd XV) |
| Saturday, 20 October 2018 |
| Altrincham Kersal Cougars (2nd XV) | 22 | 69 | Broughton Park 2nd XV |
| Burnage 2nd XV | 26 | 26 | Kirkby Lonsdale 2nd XV |
| Fylde Saracens (3rd XV) | 26 | 38 | Liverpool University Veterinarians |
| Glossop 2nd XV | 22 | 22 | Birkenhead Park Wanderers (2nd XV) |
| Penrith A XV | 20 | 41 | Sandbach 2nd XV |
| Sedgley Park 3rd XV | 27 | 25 | Warrington 2nd XV |
| Saturday, 27 October 2018 |
| Birkenhead Park Wanderers (2nd XV) | 35 | 27 | Sandbach 2nd XV |
| Glossop 2nd XV | 22 | 41 | Burnage 2nd XV |
| Kirkby Lonsdale 2nd XV | 32 | 15 | Fylde Saracens (3rd XV) |
| Liverpool University Veterinarians | 26 | 0 | Sedgley Park 3rd XV |
| Penrith A XV | 35 | 36 | Broughton Park 2nd XV |
| Warrington 2nd XV | 34 | 7 | Altrincham Kersal Cougars (2nd XV) |
| Saturday, 3 November 2018 |
| Altrincham Kersal Cougars (2nd XV) | Home Walkover | Liverpool University Veterinarians |
| Burnage 2nd XV | 17 | 42 | Birkenhead Park Wanderers (2nd XV) |
| Fylde Saracens (3rd XV) | 22 | 24 | Glossop 2nd XV |
| Penrith A XV | 29 | 14 | Warrington 2nd XV |
| Sandbach 2nd XV | 55 | 0 | Broughton Park 2nd XV |
| Sedgley Park 3rd XV | 22 | 22 | Kirkby Lonsdale 2nd XV |
| Saturday, 10 November 2018 |
| Warrington 2nd XV | 29 | 26 | Fylde Saracens (3rd XV) |
| Saturday, 17 November 2018 |
| Birkenhead Park Wanderers (2nd XV) | 67 | 22 | Broughton Park 2nd XV |
| Burnage 2nd XV | 29 | 51 | Fylde Saracens (3rd XV) |
| Glossop 2nd XV | 21 | 31 | Sedgley Park 3rd XV |
| Kirkby Lonsdale 2nd XV | 43 | 15 | Altrincham Kersal Cougars (2nd XV) |
| Liverpool University Veterinarians | 42 | 34 | Penrith A XV |
| Warrington 2nd XV | 10 | 69 | Sandbach 2nd XV |
| Saturday, 24 November 2018 |
| Altrincham Kersal Cougars (2nd XV) | 35 | 8 | Glossop 2nd XV |
| Broughton Park 2nd XV | 40 | 7 | Warrington 2nd XV |
| Fylde Saracens (3rd XV) | Away Walkover | Birkenhead Park Wanderers (2nd XV) |
| Penrith A XV | 52 | 10 | Kirkby Lonsdale 2nd XV |
| Sandbach 2nd XV | 64 | 24 | Liverpool University Veterinarians |
| Sedgley Park 3rd XV | 21 | 23 | Burnage 2nd XV |
| Saturday, 15 December 2018 |
| Burnage 2nd XV | Home Walkover | Penrith A XV |
| Fylde Saracens (3rd XV) | Home Walkover | Altrincham Kersal Cougars (2nd XV) |
| Kirkby Lonsdale 2nd XV | Home Walkover | Broughton Park 2nd XV |
| Sedgley Park 3rd XV | 12 | 19 | Birkenhead Park Wanderers (2nd XV) |
| Warrington 2nd XV | 17 | 14 | Liverpool University Veterinarians |
| Saturday, 5 January 2019 |
| Altrincham Kersal Cougars (2nd XV) | 5 | 33 | Sedgley Park 3rd XV |
| Birkenhead Park Wanderers (2nd XV) | 109 | 12 | Liverpool University Veterinarians |
| Broughton Park 2nd XV | 41 | 14 | Glossop 2nd XV |
| Penrith A XV | 66 | 40 | Fylde Saracens (3rd XV) |
| Sandbach 2nd XV | 64 | 36 | Burnage 2nd XV |
| Warrington 2nd XV | 50 | 15 | Kirkby Lonsdale 2nd XV |
| Saturday, 12 January 2019 |
| Altrincham Kersal Cougars (2nd XV) | 14 | 31 | Birkenhead Park Wanderers (2nd XV) |
| Burnage 2nd XV | 24 | 25 | Broughton Park 2nd XV |
| Fylde Saracens (3rd XV) | 19 | 19 | Sandbach 2nd XV |
| Kirkby Lonsdale 2nd XV | 50 | 17 | Liverpool University Veterinarians |
| Sedgley Park 3rd XV | 35 | 0 | Penrith A XV |
| Warrington 2nd XV | 24 | 9 | Glossop 2nd XV |
| Saturday, 19 January 2019 |
| Birkenhead Park Wanderers (2nd XV) | 97 | 0 | Kirkby Lonsdale 2nd XV |
| Broughton Park 2nd XV | 27 | 24 | Fylde Saracens (3rd XV) |
| Liverpool University Veterinarians | 0 | 8 | Glossop 2nd XV |
| Penrith A XV | 62 | 10 | Altrincham Kersal Cougars (2nd XV) |
| Sandbach 2nd XV | 77 | 0 | Sedgley Park 3rd XV |
| Warrington 2nd XV | 29 | 46 | Burnage 2nd XV |
| Saturday, 26 January 2019 |
| Altrincham Kersal Cougars (2nd XV) | 12 | 12 | Sandbach 2nd XV |
| Burnage 2nd XV | 31 | 43 | Liverpool University Veterinarians |
| Fylde Saracens (3rd XV) | 41 | 5 | Warrington 2nd XV |
| Glossop 2nd XV | 10 | 36 | Kirkby Lonsdale 2nd XV |
| Penrith A XV | 12 | 54 | Birkenhead Park Wanderers (2nd XV) |
| Sedgley Park 3rd XV | 7 | 12 | Broughton Park 2nd XV |
| Saturday, 9 February 2019 |
| Birkenhead Park Wanderers (2nd XV) | 37 | 5 | Glossop 2nd XV |
| Broughton Park 2nd XV | 55 | 40 | Altrincham Kersal Cougars (2nd XV) |
| Kirkby Lonsdale 2nd XV | Home Walkover | Burnage 2nd XV |
| Liverpool University Veterinarians | 47 | 0 | Fylde Saracens (3rd XV) |
| Sandbach 2nd XV | 96 | 5 | Penrith A XV |
| Warrington 2nd XV | 19 | 14 | Sedgley Park 3rd XV |
| Saturday, 16 February 2019 |
| Altrincham Kersal Cougars (2nd XV) | 32 | 12 | Warrington 2nd XV |
| Broughton Park 2nd XV | 50 | 19 | Penrith A XV |
| Burnage 2nd XV | 13 | 15 | Glossop 2nd XV |
| Fylde Saracens (3rd XV) | 20 | 39 | Kirkby Lonsdale 2nd XV |
| Sandbach 2nd XV | 50 | 37 | Birkenhead Park Wanderers (2nd XV) |
| Sedgley Park 3rd XV | 29 | 19 | Liverpool University Veterinarians |
| Saturday, 23 February 2019 |
| Glossop 2nd XV | 21 | 88 | Sandbach 2nd XV |
| Saturday, 2 March 2019 |
| Altrincham Kersal Cougars (2nd XV) | 34 | 35 | Liverpool University Veterinarians |
| Birkenhead Park Wanderers (2nd XV) | 68 | 18 | Burnage 2nd XV |
| Broughton Park 2nd XV | 12 | 14 | Sandbach 2nd XV |
| Glossop 2nd XV | 61 | 12 | Fylde Saracens (3rd XV) |
| Kirkby Lonsdale 2nd XV | 5 | 27 | Sedgley Park 3rd XV |
| Warrington 2nd XV | 36 | 24 | Penrith A XV |
| Saturday, 9 March 2019 |
| Altrincham Kersal Cougars (2nd XV) | 27 | 10 | Kirkby Lonsdale 2nd XV |
| Broughton Park 2nd XV | 10 | 39 | Birkenhead Park Wanderers (2nd XV) |
| Fylde Saracens (3rd XV) | 27 | 43 | Burnage 2nd XV |
| Penrith A XV | 35 | 28 | Liverpool University Veterinarians |
| Sandbach 2nd XV | 57 | 17 | Warrington 2nd XV |
| Sedgley Park 3rd XV | 10 | 15 | Glossop 2nd XV |
| Saturday, 23 March 2019 |
| Birkenhead Park Wanderers (2nd XV) | Home Walkover | Fylde Saracens (3rd XV) |
| Burnage 2nd XV | 21 | 29 | Sedgley Park 3rd XV |
| Glossop 2nd XV | Home Walkover | Altrincham Kersal Cougars (2nd XV) |
| Kirkby Lonsdale 2nd XV | 17 | 10 | Penrith A XV |
| Liverpool University Veterinarians | 44 | 0 | Sandbach 2nd XV |
| Warrington 2nd XV | 37 | 29 | Broughton Park 2nd XV |
| Saturday, 30 March 2019 |
| Broughton Park 2nd XV | 14 | 38 | Liverpool University Veterinarians |
| Saturday, 13 April 2019 |
| Altrincham Kersal Cougars (2nd XV) | 31 | 40 | Burnage 2nd XV |
| Penrith A XV | 29 | 30 | Glossop 2nd XV |
| Sandbach 2nd XV | 100 | 7 | Kirkby Lonsdale 2nd XV |
| Sedgley Park 3rd XV | 17 | 19 | Fylde Saracens (3rd XV) |
| Warrington 2nd XV | 19 | 43 | Birkenhead Park Wanderers (2nd XV) |