| Saturday, 3 September 2022 |
| Port Sunlight 2nd XV | 60 | 24 | Oldershaw 2nd XV |
| Saturday, 10 September 2022 |
| Merseyside Police | 15 | 41 | West Park (St Helens) 3rd XV |
| Sefton 3rd XV | 14 | 24 | Firwood Waterloo 3rd XV |
| Wallasey 2nd XV | 15 | 31 | Port Sunlight 2nd XV |
| Saturday, 17 September 2022 |
| Oxton Parkonians 2nd XV | 15 | 51 | Wallasey 2nd XV |
| Port Sunlight 2nd XV | 24 | 68 | Merseyside Police |
| Prenton 2nd XV | Away Walkover | Oldershaw 2nd XV |
| Southport 3rd XV | 62 | 10 | Sefton 3rd XV |
| Saturday, 24 September 2022 |
| Merseyside Police | 42 | 14 | Oxton Parkonians 2nd XV |
| Wallasey 2nd XV | 14 | 38 | Prenton 2nd XV |
| Saturday, 1 October 2022 |
| Firwood Waterloo 3rd XV | Home Walkover | Wallasey 2nd XV |
| Port Sunlight 2nd XV | 22 | 47 | Southport 3rd XV |
| Prenton 2nd XV | 69 | 17 | Merseyside Police |
| West Park (St Helens) 3rd XV | 21 | 43 | Sefton 3rd XV |
| Saturday, 8 October 2022 |
| Oldershaw 2nd XV | 68 | 5 | Oxton Parkonians 2nd XV |
| Prenton 2nd XV | 36 | 19 | Firwood Waterloo 3rd XV |
| Saturday, 15 October 2022 |
| Merseyside Police | 32 | 12 | Firwood Waterloo 3rd XV |
| Sefton 3rd XV | 45 | 27 | Oldershaw 2nd XV |
| Southport 3rd XV | 69 | 7 | Oxton Parkonians 2nd XV |
| West Park (St Helens) 3rd XV | Home Walkover | Port Sunlight 2nd XV |
| Saturday, 22 October 2022 |
| Oldershaw 2nd XV | 37 | 5 | Wallasey 2nd XV |
| Oxton Parkonians 2nd XV | Away Walkover | West Park (St Helens) 3rd XV |
| Prenton 2nd XV | 48 | 5 | Southport 3rd XV |
| Saturday, 29 October 2022 |
| Port Sunlight 2nd XV | 25 | 36 | Sefton 3rd XV |
| Southport 3rd XV | 45 | 10 | Firwood Waterloo 3rd XV |
| Saturday, 5 November 2022 |
| Merseyside Police | 71 | 5 | Wallasey 2nd XV |
| Oxton Parkonians 2nd XV | 10 | 48 | Sefton 3rd XV |
| Prenton 2nd XV | 33 | 5 | Port Sunlight 2nd XV |
| West Park (St Helens) 3rd XV | 40 | 28 | Firwood Waterloo 3rd XV |
| Saturday, 12 November 2022 |
| Port Sunlight 2nd XV | 19 | 27 | Firwood Waterloo 3rd XV |
| Prenton 2nd XV | 52 | 0 | Oxton Parkonians 2nd XV |
| Sefton 3rd XV | 10 | 34 | Merseyside Police |
| Southport 3rd XV | 43 | 7 | Oldershaw 2nd XV |
| Saturday, 19 November 2022 |
| Oldershaw 2nd XV | 40 | 7 | Firwood Waterloo 3rd XV |
| West Park (St Helens) 3rd XV | 5 | 16 | Prenton 2nd XV |
| Saturday, 26 November 2022 |
| Firwood Waterloo 3rd XV | 46 | 5 | Oxton Parkonians 2nd XV |
| Wallasey 2nd XV | 0 | 49 | Southport 3rd XV |
| Saturday, 3 December 2022 |
| Firwood Waterloo 3rd XV | 35 | 43 | Sefton 3rd XV |
| West Park (St Helens) 3rd XV | 44 | 5 | Merseyside Police |
| Saturday, 7 January 2023 |
| Firwood Waterloo 3rd XV | 67 | 12 | Wallasey 2nd XV |
| Merseyside Police | 7 | 23 | Prenton 2nd XV |
| Oxton Parkonians 2nd XV | 26 | 14 | Oldershaw 2nd XV |
| Sefton 3rd XV | 7 | 76 | West Park (St Helens) 3rd XV |
| Southport 3rd XV | 57 | 5 | Port Sunlight 2nd XV |
| Saturday, 14 January 2023 |
| Firwood Waterloo 3rd XV | Home Walkover | Merseyside Police |
| Oxton Parkonians 2nd XV | 0 | 46 | Southport 3rd XV |
| Prenton 2nd XV | 68 | 0 | Wallasey 2nd XV |
| West Park (St Helens) 3rd XV | 5 | 0 | Port Sunlight 2nd XV |
| Saturday, 21 January 2023 |
| Oldershaw 2nd XV | 19 | 26 | Wallasey 2nd XV |
| West Park (St Helens) 3rd XV | Home Walkover | Oxton Parkonians 2nd XV |
| Saturday, 28 January 2023 |
| Firwood Waterloo 3rd XV | 71 | 17 | Southport 3rd XV |
| Port Sunlight 2nd XV | 46 | 27 | Oxton Parkonians 2nd XV |
| Port Sunlight 2nd XV | 46 | 27 | Oxton Parkonians 2nd XV |
| Prenton 2nd XV | 28 | 15 | West Park (St Helens) 3rd XV |
| Sefton 3rd XV | 40 | 39 | Wallasey 2nd XV |
| Sefton 3rd XV | 40 | 39 | Wallasey 2nd XV |
| Saturday, 4 February 2023 |
| Firwood Waterloo 3rd XV | Home Walkover | Oldershaw 2nd XV |
| Oxton Parkonians 2nd XV | 14 | 24 | Merseyside Police |
| Port Sunlight 2nd XV | 5 | 5 | Wallasey 2nd XV |
| Southport 3rd XV | 38 | 22 | West Park (St Helens) 3rd XV |
| Southport 3rd XV | 38 | 22 | West Park (St Helens) 3rd XV |
| Saturday, 11 February 2023 |
| Firwood Waterloo 3rd XV | 5 | 24 | West Park (St Helens) 3rd XV |
| Port Sunlight 2nd XV | 12 | 34 | Prenton 2nd XV |
| Sefton 3rd XV | 19 | 14 | Oxton Parkonians 2nd XV |
| Wallasey 2nd XV | 12 | 31 | Merseyside Police |
| Saturday, 18 February 2023 |
| Firwood Waterloo 3rd XV | Home Walkover | Port Sunlight 2nd XV |
| Merseyside Police | 51 | 5 | Sefton 3rd XV |
| Oldershaw 2nd XV | 17 | 61 | Southport 3rd XV |
| Oxton Parkonians 2nd XV | 5 | 64 | Prenton 2nd XV |
| Saturday, 25 February 2023 |
| Oldershaw 2nd XV | Home Walkover | Sefton 3rd XV |
| Southport 3rd XV | 28 | 0 | Merseyside Police |
| Saturday, 4 March 2023 |
| Oldershaw 2nd XV | 19 | 10 | West Park (St Helens) 3rd XV |
| Oldershaw 2nd XV | 19 | 10 | West Park (St Helens) 3rd XV |
| Oxton Parkonians 2nd XV | 5 | 62 | Firwood Waterloo 3rd XV |
| Prenton 2nd XV | 113 | 0 | Sefton 3rd XV |
| Prenton 2nd XV | 113 | 0 | Sefton 3rd XV |
| Southport 3rd XV | Home Walkover | Wallasey 2nd XV |
| Saturday, 11 March 2023 |
| Firwood Waterloo 3rd XV | 19 | 7 | Prenton 2nd XV |
| Merseyside Police | 50 | 17 | Southport 3rd XV |
| Oldershaw 2nd XV | 8 | 0 | Port Sunlight 2nd XV |
| Saturday, 18 March 2023 |
| Merseyside Police | 28 | 39 | Port Sunlight 2nd XV |
| Oldershaw 2nd XV | Away Walkover | Prenton 2nd XV |
| Sefton 3rd XV | Away Walkover | Southport 3rd XV |
| Wallasey 2nd XV | 5 | 40 | Oxton Parkonians 2nd XV |
| Saturday, 25 March 2023 |
| Oldershaw 2nd XV | 28 | 26 | Merseyside Police |
| Oldershaw 2nd XV | 28 | 26 | Merseyside Police |
| Sefton 3rd XV | 23 | 26 | Port Sunlight 2nd XV |
| Southport 3rd XV | 13 | 17 | Prenton 2nd XV |
| Saturday, 1 April 2023 |
| Wallasey 2nd XV | 19 | 12 | West Park (St Helens) 3rd XV |
| Wallasey 2nd XV | 19 | 12 | West Park (St Helens) 3rd XV |