| Saturday, 3 September 2022 |
| Aldwinians 3rd XV | v | Bury 2nd XV |
| Bolton 3rd XV | v | Dukinfield 2nd XV |
| Broughton RUFC 2nd XV Men | v | Aspull 3rd XV |
| Rochdale 3rd XV | v | Sedgley Park 4th XV |
| Rossendale 3rd XV | v | Leigh 3rd XV |
| Sale FC Vikings | v | North Manchester 2nd XV |
| Saturday, 10 September 2022 |
| Bury 2nd XV | v | Broughton RUFC 2nd XV Men |
| Dukinfield 2nd XV | v | Sale FC Vikings |
| Leigh 3rd XV | v | Bolton 3rd XV |
| North Manchester 2nd XV | v | Aldwinians 3rd XV |
| Rossendale 3rd XV | v | Rochdale 3rd XV |
| Sedgley Park 4th XV | v | Aspull 3rd XV |
| Saturday, 17 September 2022 |
| Aldwinians 3rd XV | v | Dukinfield 2nd XV |
| Aspull 3rd XV | v | Bury 2nd XV |
| Bolton 3rd XV | v | Rochdale 3rd XV |
| Broughton RUFC 2nd XV Men | v | North Manchester 2nd XV |
| Sale FC Vikings | v | Leigh 3rd XV |
| Sedgley Park 4th XV | v | Rossendale 3rd XV |
| Saturday, 24 September 2022 |
| Dukinfield 2nd XV | v | Broughton RUFC 2nd XV Men |
| Leigh 3rd XV | v | Aldwinians 3rd XV |
| North Manchester 2nd XV | v | Aspull 3rd XV |
| Rochdale 3rd XV | v | Sale FC Vikings |
| Rossendale 3rd XV | v | Bolton 3rd XV |
| Sedgley Park 4th XV | v | Bury 2nd XV |
| Saturday, 1 October 2022 |
| Aldwinians 3rd XV | v | Rochdale 3rd XV |
| Aspull 3rd XV | v | Dukinfield 2nd XV |
| Bolton 3rd XV | v | Sedgley Park 4th XV |
| Broughton RUFC 2nd XV Men | v | Leigh 3rd XV |
| Bury 2nd XV | v | North Manchester 2nd XV |
| Sale FC Vikings | v | Rossendale 3rd XV |
| Saturday, 15 October 2022 |
| Bolton 3rd XV | v | Sale FC Vikings |
| Dukinfield 2nd XV | v | Bury 2nd XV |
| Leigh 3rd XV | v | Aspull 3rd XV |
| North Manchester 2nd XV | v | Sedgley Park 4th XV |
| Rochdale 3rd XV | v | Broughton RUFC 2nd XV Men |
| Rossendale 3rd XV | v | Aldwinians 3rd XV |
| Saturday, 22 October 2022 |
| Aldwinians 3rd XV | v | Bolton 3rd XV |
| Aspull 3rd XV | v | Rochdale 3rd XV |
| Broughton RUFC 2nd XV Men | v | Rossendale 3rd XV |
| Bury 2nd XV | v | Leigh 3rd XV |
| Dukinfield 2nd XV | v | North Manchester 2nd XV |
| Sale FC Vikings | v | Sedgley Park 4th XV |
| Saturday, 29 October 2022 |
| Bolton 3rd XV | v | Broughton RUFC 2nd XV Men |
| North Manchester 2nd XV | v | Leigh 3rd XV |
| Rochdale 3rd XV | v | Bury 2nd XV |
| Rossendale 3rd XV | v | Aspull 3rd XV |
| Sale FC Vikings | v | Aldwinians 3rd XV |
| Sedgley Park 4th XV | v | Dukinfield 2nd XV |
| Saturday, 5 November 2022 |
| Aldwinians 3rd XV | v | Sedgley Park 4th XV |
| Aspull 3rd XV | v | Bolton 3rd XV |
| Bury 2nd XV | v | Rossendale 3rd XV |
| Dukinfield 2nd XV | v | Leigh 3rd XV |
| Rochdale 3rd XV | v | North Manchester 2nd XV |
| Sale FC Vikings | v | Broughton RUFC 2nd XV Men |
| Saturday, 12 November 2022 |
| Bolton 3rd XV | v | Bury 2nd XV |
| Broughton RUFC 2nd XV Men | v | Aldwinians 3rd XV |
| Leigh 3rd XV | v | Sedgley Park 4th XV |
| Rochdale 3rd XV | v | Dukinfield 2nd XV |
| Rossendale 3rd XV | v | North Manchester 2nd XV |
| Sale FC Vikings | v | Aspull 3rd XV |
| Saturday, 19 November 2022 |
| Broughton RUFC 2nd XV Men | v | Rochdale 3rd XV |
| Saturday, 26 November 2022 |
| Aspull 3rd XV | v | Aldwinians 3rd XV |
| Bury 2nd XV | v | Sale FC Vikings |
| Dukinfield 2nd XV | v | Rossendale 3rd XV |
| Leigh 3rd XV | v | Rochdale 3rd XV |
| North Manchester 2nd XV | v | Bolton 3rd XV |
| Sedgley Park 4th XV | v | Broughton RUFC 2nd XV Men |
| Saturday, 3 December 2022 |
| Aldwinians 3rd XV | v | North Manchester 2nd XV |
| Aspull 3rd XV | v | Sedgley Park 4th XV |
| Bolton 3rd XV | v | Leigh 3rd XV |
| Broughton RUFC 2nd XV Men | v | Bury 2nd XV |
| Rochdale 3rd XV | v | Rossendale 3rd XV |
| Sale FC Vikings | v | Dukinfield 2nd XV |
| Saturday, 10 December 2022 |
| Bury 2nd XV | v | Aspull 3rd XV |
| Dukinfield 2nd XV | v | Aldwinians 3rd XV |
| Leigh 3rd XV | v | Sale FC Vikings |
| North Manchester 2nd XV | v | Broughton RUFC 2nd XV Men |
| Rochdale 3rd XV | v | Bolton 3rd XV |
| Rossendale 3rd XV | v | Sedgley Park 4th XV |
| Saturday, 17 December 2022 |
| Aldwinians 3rd XV | v | Leigh 3rd XV |
| Aspull 3rd XV | v | North Manchester 2nd XV |
| Bolton 3rd XV | v | Rossendale 3rd XV |
| Broughton RUFC 2nd XV Men | v | Dukinfield 2nd XV |
| Bury 2nd XV | v | Sedgley Park 4th XV |
| Sale FC Vikings | v | Rochdale 3rd XV |
| Saturday, 7 January 2023 |
| Dukinfield 2nd XV | v | Aspull 3rd XV |
| Leigh 3rd XV | v | Broughton RUFC 2nd XV Men |
| North Manchester 2nd XV | v | Bury 2nd XV |
| Rochdale 3rd XV | v | Aldwinians 3rd XV |
| Rossendale 3rd XV | v | Sale FC Vikings |
| Sedgley Park 4th XV | v | Bolton 3rd XV |
| Saturday, 14 January 2023 |
| Aldwinians 3rd XV | v | Rossendale 3rd XV |
| Aspull 3rd XV | v | Leigh 3rd XV |
| Bury 2nd XV | v | Dukinfield 2nd XV |
| Sale FC Vikings | v | Bolton 3rd XV |
| Sedgley Park 4th XV | v | North Manchester 2nd XV |
| Saturday, 21 January 2023 |
| Bolton 3rd XV | v | Aldwinians 3rd XV |
| Leigh 3rd XV | v | Bury 2nd XV |
| North Manchester 2nd XV | v | Dukinfield 2nd XV |
| Rochdale 3rd XV | v | Aspull 3rd XV |
| Rossendale 3rd XV | v | Broughton RUFC 2nd XV Men |
| Sedgley Park 4th XV | v | Sale FC Vikings |
| Saturday, 28 January 2023 |
| Aldwinians 3rd XV | v | Sale FC Vikings |
| Aspull 3rd XV | v | Rossendale 3rd XV |
| Bury 2nd XV | v | Rochdale 3rd XV |
| Dukinfield 2nd XV | v | Sedgley Park 4th XV |
| Leigh 3rd XV | v | North Manchester 2nd XV |
| Saturday, 4 February 2023 |
| Broughton RUFC 2nd XV Men | v | Bolton 3rd XV |
| Saturday, 11 February 2023 |
| Bolton 3rd XV | v | Aspull 3rd XV |
| Broughton RUFC 2nd XV Men | v | Sale FC Vikings |
| Leigh 3rd XV | v | Dukinfield 2nd XV |
| North Manchester 2nd XV | v | Rochdale 3rd XV |
| Rossendale 3rd XV | v | Bury 2nd XV |
| Sedgley Park 4th XV | v | Aldwinians 3rd XV |
| Saturday, 18 February 2023 |
| Aldwinians 3rd XV | v | Broughton RUFC 2nd XV Men |
| Aspull 3rd XV | v | Sale FC Vikings |
| Bury 2nd XV | v | Bolton 3rd XV |
| Dukinfield 2nd XV | v | Rochdale 3rd XV |
| North Manchester 2nd XV | v | Rossendale 3rd XV |
| Sedgley Park 4th XV | v | Leigh 3rd XV |
| Saturday, 4 March 2023 |
| Aldwinians 3rd XV | v | Aspull 3rd XV |
| Bolton 3rd XV | v | North Manchester 2nd XV |
| Broughton RUFC 2nd XV Men | v | Sedgley Park 4th XV |
| Rochdale 3rd XV | v | Leigh 3rd XV |
| Rossendale 3rd XV | v | Dukinfield 2nd XV |
| Sale FC Vikings | v | Bury 2nd XV |
| Saturday, 11 March 2023 |
| Aspull 3rd XV | v | Broughton RUFC 2nd XV Men |
| Bury 2nd XV | v | Aldwinians 3rd XV |
| Dukinfield 2nd XV | v | Bolton 3rd XV |
| Leigh 3rd XV | v | Rossendale 3rd XV |
| North Manchester 2nd XV | v | Sale FC Vikings |
| Sedgley Park 4th XV | v | Rochdale 3rd XV |