| Saturday, 3 September 2022 |
| Aldwinians 3rd XV | 5 | 35 | Bury 2nd XV |
| Rossendale 3rd XV | 5 | 26 | Leigh 3rd XV |
| Saturday, 10 September 2022 |
| Dukinfield 2nd XV | 24 | 41 | Sale FC Vikings |
| Rossendale 3rd XV | 23 | 60 | Rochdale 3rd XV |
| Saturday, 17 September 2022 |
| Aldwinians 3rd XV | Home Walkover | Dukinfield 2nd XV |
| Aspull 3rd XV | 12 | 39 | Bury 2nd XV |
| Sale FC Vikings | 29 | 27 | Leigh 3rd XV |
| Saturday, 24 September 2022 |
| Leigh 3rd XV | 35 | 19 | Aldwinians 3rd XV |
| Rochdale 3rd XV | 17 | 39 | Sale FC Vikings |
| Saturday, 1 October 2022 |
| Aldwinians 3rd XV | 86 | 14 | Rochdale 3rd XV |
| Aspull 3rd XV | Home Walkover | Dukinfield 2nd XV |
| Sale FC Vikings | 67 | 15 | Rossendale 3rd XV |
| Saturday, 15 October 2022 |
| Dukinfield 2nd XV | 38 | 19 | Bury 2nd XV |
| Leigh 3rd XV | 25 | 14 | Aspull 3rd XV |
| Rossendale 3rd XV | 26 | 22 | Aldwinians 3rd XV |
| Saturday, 22 October 2022 |
| Aspull 3rd XV | 17 | 22 | Rochdale 3rd XV |
| Bury 2nd XV | 8 | 30 | Leigh 3rd XV |
| Saturday, 29 October 2022 |
| Rochdale 3rd XV | 22 | 52 | Bury 2nd XV |
| Rossendale 3rd XV | Home Walkover | Aspull 3rd XV |
| Sale FC Vikings | 38 | 15 | Aldwinians 3rd XV |
| Saturday, 5 November 2022 |
| Bury 2nd XV | 6 | 0 | Rossendale 3rd XV |
| Dukinfield 2nd XV | 13 | 34 | Leigh 3rd XV |
| Saturday, 12 November 2022 |
| Rochdale 3rd XV | 36 | 0 | Dukinfield 2nd XV |
| Sale FC Vikings | 60 | 29 | Aspull 3rd XV |
| Saturday, 26 November 2022 |
| Aspull 3rd XV | 0 | 17 | Aldwinians 3rd XV |
| Bury 2nd XV | 5 | 49 | Sale FC Vikings |
| Dukinfield 2nd XV | 46 | 22 | Rossendale 3rd XV |
| Leigh 3rd XV | Home Walkover | Rochdale 3rd XV |
| Saturday, 3 December 2022 |
| Rochdale 3rd XV | Home Walkover | Rossendale 3rd XV |
| Sale FC Vikings | Home Walkover | Dukinfield 2nd XV |
| Saturday, 7 January 2023 |
| Aspull 3rd XV | 31 | 24 | Dukinfield 2nd XV |
| Rochdale 3rd XV | 17 | 43 | Aldwinians 3rd XV |
| Saturday, 14 January 2023 |
| Aldwinians 3rd XV | Home Walkover | Rossendale 3rd XV |
| Sale FC Vikings | 44 | 17 | Rochdale 3rd XV |
| Saturday, 21 January 2023 |
| Leigh 3rd XV | 5 | 0 | Bury 2nd XV |
| Saturday, 28 January 2023 |
| Aldwinians 3rd XV | 0 | 50 | Sale FC Vikings |
| Bury 2nd XV | 20 | 76 | Rochdale 3rd XV |
| Rossendale 3rd XV | 22 | 19 | Aspull 3rd XV |
| Saturday, 4 February 2023 |
| Aldwinians 3rd XV | 22 | 10 | Leigh 3rd XV |
| Bury 2nd XV | 26 | 12 | Dukinfield 2nd XV |
| Rochdale 3rd XV | 45 | 12 | Aspull 3rd XV |
| Rossendale 3rd XV | Away Walkover | Sale FC Vikings |
| Saturday, 11 February 2023 |
| Leigh 3rd XV | 12 | 7 | Dukinfield 2nd XV |
| Rossendale 3rd XV | 10 | 29 | Bury 2nd XV |
| Saturday, 18 February 2023 |
| Aspull 3rd XV | 0 | 27 | Sale FC Vikings |
| Dukinfield 2nd XV | 87 | 12 | Rochdale 3rd XV |
| Saturday, 25 February 2023 |
| Aldwinians 3rd XV | 24 | 24 | Dukinfield 2nd XV |
| Aspull 3rd XV | Away Walkover | Leigh 3rd XV |
| Saturday, 4 March 2023 |
| Aldwinians 3rd XV | 32 | 59 | Aspull 3rd XV |
| Leigh 3rd XV | 34 | 19 | Rochdale 3rd XV |
| Rossendale 3rd XV | 67 | 7 | Dukinfield 2nd XV |
| Sale FC Vikings | 57 | 17 | Bury 2nd XV |
| Saturday, 11 March 2023 |
| Bury 2nd XV | 5 | 27 | Aldwinians 3rd XV |
| Leigh 3rd XV | 0 | 21 | Rossendale 3rd XV |
| Saturday, 18 March 2023 |
| Bury 2nd XV | 17 | 17 | Aspull 3rd XV |
| Leigh 3rd XV | Away Walkover | Sale FC Vikings |