| Saturday, 6 September 2025 |
| Glossop 2nd XV | 3 | 63 | Lymm Eagles |
| Stockport 3rd XV | 31 | 40 | Northwich 2nd XV |
| Wilmslow 2nd XV | 31 | 19 | Moore |
| Saturday, 13 September 2025 |
| Lymm Eagles | 35 | 55 | Heaton Moor 2nd XV |
| Macclesfield 3rd XV | 19 | 76 | Winnington Park 2nd XV |
| Moore | 35 | 3 | Stockport 3rd XV |
| Northwich 2nd XV | 59 | 10 | Glossop 2nd XV |
| Saturday, 20 September 2025 |
| Glossop 2nd XV | 3 | 25 | Moore |
| Heaton Moor 2nd XV | 31 | 14 | Northwich 2nd XV |
| Wilmslow 2nd XV | 57 | 12 | Macclesfield 3rd XV |
| Saturday, 27 September 2025 |
| Northwich 2nd XV | Home Walkover | Lymm Eagles |
| Stockport 3rd XV | 60 | 19 | Liverpool University Veterinarians |
| Stockport 3rd XV | 60 | 19 | Liverpool University Veterinarians |
| Winnington Park 2nd XV | 20 | 19 | Manchester Medics |
| Saturday, 4 October 2025 |
| Lymm Eagles | 26 | 38 | Manchester Medics |
| Macclesfield 3rd XV | Away Walkover | Stockport 3rd XV |
| Moore | 78 | 17 | Heaton Moor 2nd XV |
| Northwich 2nd XV | 14 | 21 | Liverpool Medical School |
| Wilmslow 2nd XV | 47 | 12 | Winnington Park 2nd XV |
| Saturday, 11 October 2025 |
| Glossop 2nd XV | v | Macclesfield 3rd XV |
| Liverpool Medical School | v | Moore |
| Liverpool University Veterinarians | v | Heaton Moor 2nd XV |
| Manchester Medics | v | Northwich 2nd XV |
| Stockport 3rd XV | v | Wilmslow 2nd XV |
| Winnington Park 2nd XV | v | Lymm Eagles |
| Saturday, 18 October 2025 |
| Heaton Moor 2nd XV | v | Macclesfield 3rd XV |
| Liverpool University Veterinarians | v | Glossop 2nd XV |
| Moore | v | Manchester Medics |
| Stockport 3rd XV | v | Winnington Park 2nd XV |
| Saturday, 25 October 2025 |
| Glossop 2nd XV | v | Stockport 3rd XV |
| Liverpool University Veterinarians | v | Liverpool Medical School |
| Lymm Eagles | v | Moore |
| Wilmslow 2nd XV | v | Heaton Moor 2nd XV |
| Winnington Park 2nd XV | v | Northwich 2nd XV |
| Saturday, 1 November 2025 |
| Lymm Eagles | v | Liverpool Medical School |
| Saturday, 8 November 2025 |
| Glossop 2nd XV | v | Winnington Park 2nd XV |
| Liverpool University Veterinarians | v | Lymm Eagles |
| Manchester Medics | v | Macclesfield 3rd XV |
| Moore | v | Northwich 2nd XV |
| Stockport 3rd XV | v | Heaton Moor 2nd XV |
| Wilmslow 2nd XV | v | Liverpool Medical School |
| Saturday, 15 November 2025 |
| Heaton Moor 2nd XV | v | Manchester Medics |
| Heaton Moor 2nd XV | v | Manchester Medics |
| Macclesfield 3rd XV | v | Liverpool University Veterinarians |
| Wilmslow 2nd XV | v | Glossop 2nd XV |
| Winnington Park 2nd XV | v | Liverpool Medical School |
| Saturday, 22 November 2025 |
| Heaton Moor 2nd XV | v | Glossop 2nd XV |
| Liverpool Medical School | v | Stockport 3rd XV |
| Lymm Eagles | v | Macclesfield 3rd XV |
| Manchester Medics | v | Wilmslow 2nd XV |
| Northwich 2nd XV | v | Liverpool University Veterinarians |
| Winnington Park 2nd XV | v | Moore |
| Saturday, 29 November 2025 |
| Glossop 2nd XV | v | Liverpool Medical School |
| Heaton Moor 2nd XV | v | Winnington Park 2nd XV |
| Liverpool University Veterinarians | v | Moore |
| Macclesfield 3rd XV | v | Northwich 2nd XV |
| Stockport 3rd XV | v | Manchester Medics |
| Wilmslow 2nd XV | v | Lymm Eagles |
| Saturday, 6 December 2025 |
| Liverpool Medical School | v | Heaton Moor 2nd XV |
| Lymm Eagles | v | Stockport 3rd XV |
| Manchester Medics | v | Glossop 2nd XV |
| Moore | v | Macclesfield 3rd XV |
| Northwich 2nd XV | v | Wilmslow 2nd XV |
| Winnington Park 2nd XV | v | Liverpool University Veterinarians |
| Saturday, 13 December 2025 |
| Glossop 2nd XV | v | Northwich 2nd XV |
| Heaton Moor 2nd XV | v | Lymm Eagles |
| Manchester Medics | v | Liverpool Medical School |
| Stockport 3rd XV | v | Moore |
| Wilmslow 2nd XV | v | Liverpool University Veterinarians |
| Winnington Park 2nd XV | v | Macclesfield 3rd XV |
| Saturday, 20 December 2025 |
| Macclesfield 3rd XV | v | Wilmslow 2nd XV |
| Moore | v | Glossop 2nd XV |
| Northwich 2nd XV | v | Heaton Moor 2nd XV |
| Saturday, 10 January 2026 |
| Glossop 2nd XV | v | Liverpool University Veterinarians |
| Heaton Moor 2nd XV | v | Moore |
| Liverpool Medical School | v | Northwich 2nd XV |
| Manchester Medics | v | Lymm Eagles |
| Stockport 3rd XV | v | Macclesfield 3rd XV |
| Winnington Park 2nd XV | v | Wilmslow 2nd XV |
| Saturday, 17 January 2026 |
| Heaton Moor 2nd XV | v | Liverpool University Veterinarians |
| Lymm Eagles | v | Winnington Park 2nd XV |
| Macclesfield 3rd XV | v | Glossop 2nd XV |
| Moore | v | Liverpool Medical School |
| Northwich 2nd XV | v | Manchester Medics |
| Wilmslow 2nd XV | v | Stockport 3rd XV |
| Saturday, 24 January 2026 |
| Liverpool Medical School | v | Manchester Medics |
| Liverpool University Veterinarians | v | Wilmslow 2nd XV |
| Saturday, 31 January 2026 |
| Glossop 2nd XV | v | Wilmslow 2nd XV |
| Liverpool Medical School | v | Liverpool University Veterinarians |
| Macclesfield 3rd XV | v | Heaton Moor 2nd XV |
| Manchester Medics | v | Moore |
| Northwich 2nd XV | v | Lymm Eagles |
| Winnington Park 2nd XV | v | Stockport 3rd XV |
| Saturday, 14 February 2026 |
| Heaton Moor 2nd XV | v | Wilmslow 2nd XV |
| Liverpool University Veterinarians | v | Manchester Medics |
| Liverpool University Veterinarians | v | Manchester Medics |
| Macclesfield 3rd XV | v | Liverpool Medical School |
| Macclesfield 3rd XV | v | Liverpool Medical School |
| Moore | v | Lymm Eagles |
| Northwich 2nd XV | v | Winnington Park 2nd XV |
| Stockport 3rd XV | v | Glossop 2nd XV |
| Saturday, 21 February 2026 |
| Liverpool Medical School | v | Lymm Eagles |
| Manchester Medics | v | Winnington Park 2nd XV |
| Saturday, 28 February 2026 |
| Heaton Moor 2nd XV | v | Stockport 3rd XV |
| Liverpool Medical School | v | Wilmslow 2nd XV |
| Lymm Eagles | v | Liverpool University Veterinarians |
| Macclesfield 3rd XV | v | Manchester Medics |
| Northwich 2nd XV | v | Moore |
| Winnington Park 2nd XV | v | Glossop 2nd XV |
| Saturday, 7 March 2026 |
| Glossop 2nd XV | v | Heaton Moor 2nd XV |
| Liverpool University Veterinarians | v | Northwich 2nd XV |
| Macclesfield 3rd XV | v | Lymm Eagles |
| Moore | v | Winnington Park 2nd XV |
| Stockport 3rd XV | v | Liverpool Medical School |
| Wilmslow 2nd XV | v | Manchester Medics |
| Saturday, 21 March 2026 |
| Liverpool Medical School | v | Glossop 2nd XV |
| Lymm Eagles | v | Wilmslow 2nd XV |
| Manchester Medics | v | Stockport 3rd XV |
| Moore | v | Liverpool University Veterinarians |
| Northwich 2nd XV | v | Macclesfield 3rd XV |
| Winnington Park 2nd XV | v | Heaton Moor 2nd XV |
| Saturday, 28 March 2026 |
| Glossop 2nd XV | v | Manchester Medics |
| Heaton Moor 2nd XV | v | Liverpool Medical School |
| Liverpool University Veterinarians | v | Winnington Park 2nd XV |
| Macclesfield 3rd XV | v | Moore |
| Stockport 3rd XV | v | Lymm Eagles |
| Wilmslow 2nd XV | v | Northwich 2nd XV |
| Saturday, 11 April 2026 |
| Liverpool Medical School | v | Winnington Park 2nd XV |
| Liverpool University Veterinarians | v | Macclesfield 3rd XV |
| Lymm Eagles | v | Glossop 2nd XV |
| Moore | v | Wilmslow 2nd XV |
| Northwich 2nd XV | v | Stockport 3rd XV |