| Saturday, 6 September 2025 |
| Lymm 2nd XV | 36 | 31 | Sale FC Vikings |
| Manchester 2nd XV | 22 | 87 | Macclesfield 2nd XV |
| Rossendale 2nd XV | 20 | 50 | Sedgley Park 2nd XV |
| Stockport 2nd XV | 34 | 59 | Chester 2nd XV |
| Wirral 2nd XV | 0 | 49 | Caldy 2nd XV |
| Saturday, 13 September 2025 |
| Caldy 2nd XV | 40 | 21 | Stockport 2nd XV |
| Chester 2nd XV | 5 | 22 | Lymm 2nd XV |
| Fylde Hawks (2nd XV) | 5 | 49 | Preston Grasshoppers 2nd XV |
| Rossendale 2nd XV | 12 | 57 | Macclesfield 2nd XV |
| Sale FC Vikings | 50 | 10 | Manchester 2nd XV |
| Friday, 19 September 2025 |
| Lymm 2nd XV | 36 | 39 | Caldy 2nd XV |
| Saturday, 20 September 2025 |
| Manchester 2nd XV | 10 | 45 | Chester 2nd XV |
| Preston Grasshoppers 2nd XV | 59 | 24 | Sedgley Park 2nd XV |
| Rossendale 2nd XV | 0 | 61 | Sale FC Vikings |
| Stockport 2nd XV | 15 | 21 | Wirral 2nd XV |
| Saturday, 27 September 2025 |
| Caldy 2nd XV | 43 | 14 | Manchester 2nd XV |
| Preston Grasshoppers 2nd XV | 90 | 17 | Macclesfield 2nd XV |
| Sedgley Park 2nd XV | Home Walkover | Fylde Hawks (2nd XV) |
| Wirral 2nd XV | 12 | 18 | Lymm 2nd XV |
| Saturday, 4 October 2025 |
| Fylde Hawks (2nd XV) | 31 | 29 | Macclesfield 2nd XV |
| Lymm 2nd XV | 33 | 36 | Stockport 2nd XV |
| Manchester 2nd XV | 12 | 5 | Wirral 2nd XV |
| Preston Grasshoppers 2nd XV | 38 | 24 | Sale FC Vikings |
| Rossendale 2nd XV | Away Walkover | Caldy 2nd XV |
| Saturday, 11 October 2025 |
| Chester 2nd XV | v | Preston Grasshoppers 2nd XV |
| Macclesfield 2nd XV | v | Sedgley Park 2nd XV |
| Manchester 2nd XV | v | Stockport 2nd XV |
| Sale FC Vikings | v | Fylde Hawks (2nd XV) |
| Wirral 2nd XV | v | Rossendale 2nd XV |
| Saturday, 18 October 2025 |
| Fylde Hawks (2nd XV) | v | Chester 2nd XV |
| Manchester 2nd XV | v | Lymm 2nd XV |
| Rossendale 2nd XV | v | Stockport 2nd XV |
| Sedgley Park 2nd XV | v | Sale FC Vikings |
| Saturday, 25 October 2025 |
| Caldy 2nd XV | v | Fylde Hawks (2nd XV) |
| Chester 2nd XV | v | Sedgley Park 2nd XV |
| Lymm 2nd XV | v | Rossendale 2nd XV |
| Sale FC Vikings | v | Macclesfield 2nd XV |
| Wirral 2nd XV | v | Preston Grasshoppers 2nd XV |
| Saturday, 8 November 2025 |
| Fylde Hawks (2nd XV) | v | Wirral 2nd XV |
| Macclesfield 2nd XV | v | Chester 2nd XV |
| Preston Grasshoppers 2nd XV | v | Stockport 2nd XV |
| Rossendale 2nd XV | v | Manchester 2nd XV |
| Sedgley Park 2nd XV | v | Caldy 2nd XV |
| Saturday, 15 November 2025 |
| Chester 2nd XV | v | Sale FC Vikings |
| Lymm 2nd XV | v | Preston Grasshoppers 2nd XV |
| Macclesfield 2nd XV | v | Caldy 2nd XV |
| Stockport 2nd XV | v | Fylde Hawks (2nd XV) |
| Wirral 2nd XV | v | Sedgley Park 2nd XV |
| Saturday, 22 November 2025 |
| Chester 2nd XV | v | Rossendale 2nd XV |
| Fylde Hawks (2nd XV) | v | Lymm 2nd XV |
| Macclesfield 2nd XV | v | Wirral 2nd XV |
| Preston Grasshoppers 2nd XV | v | Manchester 2nd XV |
| Sale FC Vikings | v | Caldy 2nd XV |
| Sedgley Park 2nd XV | v | Stockport 2nd XV |
| Saturday, 29 November 2025 |
| Rossendale 2nd XV | v | Preston Grasshoppers 2nd XV |
| Saturday, 6 December 2025 |
| Caldy 2nd XV | v | Chester 2nd XV |
| Lymm 2nd XV | v | Sedgley Park 2nd XV |
| Manchester 2nd XV | v | Fylde Hawks (2nd XV) |
| Stockport 2nd XV | v | Macclesfield 2nd XV |
| Wirral 2nd XV | v | Sale FC Vikings |
| Saturday, 13 December 2025 |
| Chester 2nd XV | v | Wirral 2nd XV |
| Fylde Hawks (2nd XV) | v | Rossendale 2nd XV |
| Macclesfield 2nd XV | v | Lymm 2nd XV |
| Sale FC Vikings | v | Stockport 2nd XV |
| Sedgley Park 2nd XV | v | Manchester 2nd XV |
| Saturday, 20 December 2025 |
| Lymm 2nd XV | v | Chester 2nd XV |
| Macclesfield 2nd XV | v | Rossendale 2nd XV |
| Manchester 2nd XV | v | Sale FC Vikings |
| Preston Grasshoppers 2nd XV | v | Fylde Hawks (2nd XV) |
| Stockport 2nd XV | v | Caldy 2nd XV |
| Saturday, 10 January 2026 |
| Caldy 2nd XV | v | Lymm 2nd XV |
| Chester 2nd XV | v | Manchester 2nd XV |
| Sale FC Vikings | v | Rossendale 2nd XV |
| Sedgley Park 2nd XV | v | Preston Grasshoppers 2nd XV |
| Wirral 2nd XV | v | Stockport 2nd XV |
| Saturday, 17 January 2026 |
| Lymm 2nd XV | v | Wirral 2nd XV |
| Macclesfield 2nd XV | v | Preston Grasshoppers 2nd XV |
| Manchester 2nd XV | v | Caldy 2nd XV |
| Sedgley Park 2nd XV | v | Fylde Hawks (2nd XV) |
| Saturday, 24 January 2026 |
| Caldy 2nd XV | v | Rossendale 2nd XV |
| Macclesfield 2nd XV | v | Fylde Hawks (2nd XV) |
| Sale FC Vikings | v | Preston Grasshoppers 2nd XV |
| Stockport 2nd XV | v | Lymm 2nd XV |
| Wirral 2nd XV | v | Manchester 2nd XV |
| Saturday, 31 January 2026 |
| Fylde Hawks (2nd XV) | v | Sale FC Vikings |
| Preston Grasshoppers 2nd XV | v | Chester 2nd XV |
| Rossendale 2nd XV | v | Wirral 2nd XV |
| Sedgley Park 2nd XV | v | Macclesfield 2nd XV |
| Stockport 2nd XV | v | Manchester 2nd XV |
| Saturday, 14 February 2026 |
| Caldy 2nd XV | v | Preston Grasshoppers 2nd XV |
| Chester 2nd XV | v | Fylde Hawks (2nd XV) |
| Lymm 2nd XV | v | Manchester 2nd XV |
| Sale FC Vikings | v | Sedgley Park 2nd XV |
| Stockport 2nd XV | v | Rossendale 2nd XV |
| Saturday, 21 February 2026 |
| Fylde Hawks (2nd XV) | v | Caldy 2nd XV |
| Macclesfield 2nd XV | v | Sale FC Vikings |
| Preston Grasshoppers 2nd XV | v | Wirral 2nd XV |
| Rossendale 2nd XV | v | Lymm 2nd XV |
| Sedgley Park 2nd XV | v | Chester 2nd XV |
| Saturday, 28 February 2026 |
| Caldy 2nd XV | v | Sedgley Park 2nd XV |
| Chester 2nd XV | v | Macclesfield 2nd XV |
| Manchester 2nd XV | v | Rossendale 2nd XV |
| Stockport 2nd XV | v | Preston Grasshoppers 2nd XV |
| Wirral 2nd XV | v | Fylde Hawks (2nd XV) |
| Saturday, 14 March 2026 |
| Caldy 2nd XV | v | Macclesfield 2nd XV |
| Fylde Hawks (2nd XV) | v | Stockport 2nd XV |
| Preston Grasshoppers 2nd XV | v | Lymm 2nd XV |
| Sale FC Vikings | v | Chester 2nd XV |
| Sedgley Park 2nd XV | v | Wirral 2nd XV |
| Saturday, 21 March 2026 |
| Caldy 2nd XV | v | Sale FC Vikings |
| Lymm 2nd XV | v | Fylde Hawks (2nd XV) |
| Manchester 2nd XV | v | Preston Grasshoppers 2nd XV |
| Rossendale 2nd XV | v | Chester 2nd XV |
| Stockport 2nd XV | v | Sedgley Park 2nd XV |
| Wirral 2nd XV | v | Macclesfield 2nd XV |
| Saturday, 11 April 2026 |
| Chester 2nd XV | v | Caldy 2nd XV |
| Fylde Hawks (2nd XV) | v | Manchester 2nd XV |
| Macclesfield 2nd XV | v | Stockport 2nd XV |
| Preston Grasshoppers 2nd XV | v | Rossendale 2nd XV |
| Sale FC Vikings | v | Wirral 2nd XV |
| Sedgley Park 2nd XV | v | Lymm 2nd XV |
| Friday, 17 April 2026 |
| Preston Grasshoppers 2nd XV | v | Caldy 2nd XV |
| Saturday, 18 April 2026 |
| Lymm 2nd XV | v | Macclesfield 2nd XV |
| Manchester 2nd XV | v | Sedgley Park 2nd XV |
| Rossendale 2nd XV | v | Fylde Hawks (2nd XV) |
| Stockport 2nd XV | v | Sale FC Vikings |
| Wirral 2nd XV | v | Chester 2nd XV |
| Saturday, 25 April 2026 |
| Caldy 2nd XV | v | Wirral 2nd XV |
| Chester 2nd XV | v | Stockport 2nd XV |
| Macclesfield 2nd XV | v | Manchester 2nd XV |
| Sale FC Vikings | v | Lymm 2nd XV |
| Sedgley Park 2nd XV | v | Rossendale 2nd XV |