| Saturday, 6 September 2025 |
| Caldy 3rd XV | v | New Brighton 2nd XV |
| Capenhurst | v | Crosby St Mary's |
| Chester 3rd XV | v | Newton-le-Willows |
| Oxton Parkonians | v | Port Sunlight |
| Ruskin Park | v | Birchfield |
| Saturday, 13 September 2025 |
| Birchfield | v | Port Sunlight |
| Caldy 3rd XV | v | Oxton Parkonians |
| New Brighton 2nd XV | v | Chester 3rd XV |
| Newton-le-Willows | v | Capenhurst |
| Sefton 2nd XV | v | Ruskin Park |
| Saturday, 20 September 2025 |
| Crosby St Mary's | v | Chester 3rd XV |
| Saturday, 4 October 2025 |
| Capenhurst | v | New Brighton 2nd XV |
| Chester 3rd XV | v | Caldy 3rd XV |
| Oxton Parkonians | v | Birchfield |
| Port Sunlight | v | Sefton 2nd XV |
| Ruskin Park | v | Crosby St Mary's |
| Saturday, 11 October 2025 |
| Caldy 3rd XV | v | Capenhurst |
| Chester 3rd XV | v | Oxton Parkonians |
| Crosby St Mary's | v | Port Sunlight |
| Newton-le-Willows | v | Ruskin Park |
| Sefton 2nd XV | v | Birchfield |
| Saturday, 18 October 2025 |
| Birchfield | v | Crosby St Mary's |
| Capenhurst | v | Chester 3rd XV |
| Oxton Parkonians | v | Sefton 2nd XV |
| Port Sunlight | v | Newton-le-Willows |
| Ruskin Park | v | New Brighton 2nd XV |
| Saturday, 8 November 2025 |
| Caldy 3rd XV | v | Ruskin Park |
| Capenhurst | v | Oxton Parkonians |
| Crosby St Mary's | v | Sefton 2nd XV |
| New Brighton 2nd XV | v | Port Sunlight |
| Newton-le-Willows | v | Birchfield |
| Saturday, 22 November 2025 |
| Birchfield | v | New Brighton 2nd XV |
| Oxton Parkonians | v | Crosby St Mary's |
| Port Sunlight | v | Caldy 3rd XV |
| Ruskin Park | v | Chester 3rd XV |
| Sefton 2nd XV | v | Newton-le-Willows |
| Saturday, 29 November 2025 |
| Caldy 3rd XV | v | Birchfield |
| Capenhurst | v | Ruskin Park |
| Chester 3rd XV | v | Port Sunlight |
| New Brighton 2nd XV | v | Sefton 2nd XV |
| Newton-le-Willows | v | Crosby St Mary's |
| Saturday, 6 December 2025 |
| Birchfield | v | Chester 3rd XV |
| Crosby St Mary's | v | New Brighton 2nd XV |
| Oxton Parkonians | v | Newton-le-Willows |
| Port Sunlight | v | Capenhurst |
| Sefton 2nd XV | v | Caldy 3rd XV |
| Saturday, 13 December 2025 |
| Caldy 3rd XV | v | Crosby St Mary's |
| Capenhurst | v | Birchfield |
| Chester 3rd XV | v | Sefton 2nd XV |
| New Brighton 2nd XV | v | Newton-le-Willows |
| Ruskin Park | v | Oxton Parkonians |
| Saturday, 20 December 2025 |
| Newton-le-Willows | v | Caldy 3rd XV |
| Oxton Parkonians | v | New Brighton 2nd XV |
| Port Sunlight | v | Ruskin Park |
| Sefton 2nd XV | v | Capenhurst |
| Saturday, 10 January 2026 |
| Capenhurst | v | Newton-le-Willows |
| Chester 3rd XV | v | New Brighton 2nd XV |
| Oxton Parkonians | v | Caldy 3rd XV |
| Port Sunlight | v | Birchfield |
| Ruskin Park | v | Sefton 2nd XV |
| Saturday, 17 January 2026 |
| Birchfield | v | Oxton Parkonians |
| Caldy 3rd XV | v | Chester 3rd XV |
| Crosby St Mary's | v | Ruskin Park |
| New Brighton 2nd XV | v | Capenhurst |
| Sefton 2nd XV | v | Port Sunlight |
| Saturday, 24 January 2026 |
| Birchfield | v | Sefton 2nd XV |
| Capenhurst | v | Caldy 3rd XV |
| Oxton Parkonians | v | Chester 3rd XV |
| Port Sunlight | v | Crosby St Mary's |
| Ruskin Park | v | Newton-le-Willows |
| Saturday, 14 February 2026 |
| Chester 3rd XV | v | Capenhurst |
| Crosby St Mary's | v | Birchfield |
| New Brighton 2nd XV | v | Ruskin Park |
| Newton-le-Willows | v | Port Sunlight |
| Sefton 2nd XV | v | Oxton Parkonians |
| Saturday, 28 February 2026 |
| Birchfield | v | Newton-le-Willows |
| Oxton Parkonians | v | Capenhurst |
| Port Sunlight | v | New Brighton 2nd XV |
| Ruskin Park | v | Caldy 3rd XV |
| Sefton 2nd XV | v | Crosby St Mary's |
| Saturday, 7 March 2026 |
| Caldy 3rd XV | v | Port Sunlight |
| Chester 3rd XV | v | Ruskin Park |
| Crosby St Mary's | v | Oxton Parkonians |
| New Brighton 2nd XV | v | Birchfield |
| Newton-le-Willows | v | Sefton 2nd XV |
| Saturday, 21 March 2026 |
| Birchfield | v | Caldy 3rd XV |
| Crosby St Mary's | v | Newton-le-Willows |
| Port Sunlight | v | Chester 3rd XV |
| Ruskin Park | v | Capenhurst |
| Sefton 2nd XV | v | New Brighton 2nd XV |
| Saturday, 28 March 2026 |
| Caldy 3rd XV | v | Sefton 2nd XV |
| Capenhurst | v | Port Sunlight |
| Chester 3rd XV | v | Birchfield |
| New Brighton 2nd XV | v | Crosby St Mary's |
| Newton-le-Willows | v | Oxton Parkonians |
| Saturday, 11 April 2026 |
| Birchfield | v | Capenhurst |
| Crosby St Mary's | v | Caldy 3rd XV |
| Newton-le-Willows | v | New Brighton 2nd XV |
| Oxton Parkonians | v | Ruskin Park |
| Sefton 2nd XV | v | Chester 3rd XV |
| Saturday, 18 April 2026 |
| Caldy 3rd XV | v | Newton-le-Willows |
| Capenhurst | v | Sefton 2nd XV |
| Chester 3rd XV | v | Crosby St Mary's |
| New Brighton 2nd XV | v | Oxton Parkonians |
| Ruskin Park | v | Port Sunlight |
| Saturday, 25 April 2026 |
| Birchfield | v | Ruskin Park |
| Crosby St Mary's | v | Capenhurst |
| New Brighton 2nd XV | v | Caldy 3rd XV |
| Newton-le-Willows | v | Chester 3rd XV |
| Port Sunlight | v | Oxton Parkonians |