| Saturday, 6 September 2025 |
| Blackburn RUFC Vikings | 29 | 14 | Bolton 2nd XV |
| Garstang Blues (2nd XV) | Home Walkover | Orrell 2nd XV |
| Preston Grasshoppers 4th XV | 64 | 19 | Eccles 3rd XV |
| Trafford MV 2nd XV | 12 | 19 | Altrincham Kersal Cougars (2nd XV) |
| Warrington 2nd XV | 80 | 12 | Bury 2nd XV |
| Saturday, 13 September 2025 |
| Altrincham Kersal Cougars (2nd XV) | Away Walkover | Preston Grasshoppers 4th XV |
| Bury 2nd XV | 45 | 5 | Trafford MV 2nd XV |
| Eccles 3rd XV | 29 | 3 | Bolton 2nd XV |
| North Manchester | 28 | 19 | Blackburn RUFC Vikings |
| Orrell 2nd XV | 12 | 72 | Warrington 2nd XV |
| Saturday, 20 September 2025 |
| North Manchester | 62 | 0 | Vale of Lune 3rd XV |
| Saturday, 27 September 2025 |
| Vale of Lune 3rd XV | 26 | 24 | Garstang Blues (2nd XV) |
| Saturday, 4 October 2025 |
| Blackburn RUFC Vikings | 72 | 7 | Eccles 3rd XV |
| North Manchester | 10 | 41 | Garstang Blues (2nd XV) |
| Preston Grasshoppers 4th XV | 0 | 46 | Bury 2nd XV |
| Trafford MV 2nd XV | Home Walkover | Orrell 2nd XV |
| Saturday, 11 October 2025 |
| Altrincham Kersal Cougars (2nd XV) | 10 | 55 | Eccles 3rd XV |
| Bury 2nd XV | 17 | 24 | Bolton 2nd XV |
| Garstang Blues (2nd XV) | 18 | 16 | Blackburn RUFC Vikings |
| North Manchester | 34 | 33 | Warrington 2nd XV |
| Orrell 2nd XV | 77 | 28 | Preston Grasshoppers 4th XV |
| Vale of Lune 3rd XV | 63 | 19 | Trafford MV 2nd XV |
| Saturday, 18 October 2025 |
| Altrincham Kersal Cougars (2nd XV) | 10 | 28 | Vale of Lune 3rd XV |
| Bolton 2nd XV | 14 | 10 | Orrell 2nd XV |
| Eccles 3rd XV | Away Walkover | Bury 2nd XV |
| Trafford MV 2nd XV | 27 | 24 | North Manchester |
| Warrington 2nd XV | 24 | 17 | Garstang Blues (2nd XV) |
| Saturday, 25 October 2025 |
| Blackburn RUFC Vikings | 76 | 5 | Altrincham Kersal Cougars (2nd XV) |
| Preston Grasshoppers 4th XV | Postponed | Vale of Lune 3rd XV |
| Warrington 2nd XV | 72 | 12 | Vale of Lune 3rd XV |
| Saturday, 8 November 2025 |
| Bury 2nd XV | v | Altrincham Kersal Cougars (2nd XV) |
| Garstang Blues (2nd XV) | v | Trafford MV 2nd XV |
| North Manchester | v | Preston Grasshoppers 4th XV |
| Orrell 2nd XV | v | Eccles 3rd XV |
| Warrington 2nd XV | v | Blackburn RUFC Vikings |
| Saturday, 15 November 2025 |
| Vale of Lune 3rd XV | v | Bolton 2nd XV |
| Saturday, 22 November 2025 |
| Altrincham Kersal Cougars (2nd XV) | v | Orrell 2nd XV |
| Blackburn RUFC Vikings | v | Bury 2nd XV |
| Bolton 2nd XV | v | North Manchester |
| Eccles 3rd XV | v | Vale of Lune 3rd XV |
| Preston Grasshoppers 4th XV | v | Garstang Blues (2nd XV) |
| Trafford MV 2nd XV | v | Warrington 2nd XV |
| Saturday, 29 November 2025 |
| Garstang Blues (2nd XV) | v | Bolton 2nd XV |
| North Manchester | v | Eccles 3rd XV |
| Orrell 2nd XV | v | Bury 2nd XV |
| Trafford MV 2nd XV | v | Blackburn RUFC Vikings |
| Warrington 2nd XV | v | Preston Grasshoppers 4th XV |
| Saturday, 6 December 2025 |
| Altrincham Kersal Cougars (2nd XV) | v | North Manchester |
| Blackburn RUFC Vikings | v | Orrell 2nd XV |
| Bolton 2nd XV | v | Warrington 2nd XV |
| Eccles 3rd XV | v | Garstang Blues (2nd XV) |
| Preston Grasshoppers 4th XV | v | Trafford MV 2nd XV |
| Saturday, 13 December 2025 |
| Garstang Blues (2nd XV) | v | Altrincham Kersal Cougars (2nd XV) |
| North Manchester | v | Bury 2nd XV |
| Preston Grasshoppers 4th XV | v | Blackburn RUFC Vikings |
| Trafford MV 2nd XV | v | Bolton 2nd XV |
| Vale of Lune 3rd XV | v | Orrell 2nd XV |
| Warrington 2nd XV | v | Eccles 3rd XV |
| Saturday, 20 December 2025 |
| Altrincham Kersal Cougars (2nd XV) | v | Warrington 2nd XV |
| Blackburn RUFC Vikings | v | Vale of Lune 3rd XV |
| Bolton 2nd XV | v | Preston Grasshoppers 4th XV |
| Bury 2nd XV | v | Garstang Blues (2nd XV) |
| Eccles 3rd XV | v | Trafford MV 2nd XV |
| Orrell 2nd XV | v | North Manchester |
| Saturday, 10 January 2026 |
| Blackburn RUFC Vikings | v | North Manchester |
| Bolton 2nd XV | v | Eccles 3rd XV |
| Garstang Blues (2nd XV) | v | Vale of Lune 3rd XV |
| Preston Grasshoppers 4th XV | v | Altrincham Kersal Cougars (2nd XV) |
| Trafford MV 2nd XV | v | Bury 2nd XV |
| Warrington 2nd XV | v | Orrell 2nd XV |
| Saturday, 17 January 2026 |
| Altrincham Kersal Cougars (2nd XV) | v | Bolton 2nd XV |
| Altrincham Kersal Cougars (2nd XV) | v | Bolton 2nd XV |
| Bury 2nd XV | v | Preston Grasshoppers 4th XV |
| Eccles 3rd XV | v | Blackburn RUFC Vikings |
| Garstang Blues (2nd XV) | v | North Manchester |
| Trafford MV 2nd XV | v | Orrell 2nd XV |
| Vale of Lune 3rd XV | v | Warrington 2nd XV |
| Saturday, 24 January 2026 |
| Blackburn RUFC Vikings | v | Garstang Blues (2nd XV) |
| Bolton 2nd XV | v | Bury 2nd XV |
| Eccles 3rd XV | v | Altrincham Kersal Cougars (2nd XV) |
| Preston Grasshoppers 4th XV | v | Orrell 2nd XV |
| Trafford MV 2nd XV | v | Vale of Lune 3rd XV |
| Warrington 2nd XV | v | North Manchester |
| Saturday, 31 January 2026 |
| Preston Grasshoppers 4th XV | v | Bolton 2nd XV |
| Vale of Lune 3rd XV | v | Altrincham Kersal Cougars (2nd XV) |
| Saturday, 14 February 2026 |
| Altrincham Kersal Cougars (2nd XV) | v | Blackburn RUFC Vikings |
| Bury 2nd XV | v | Eccles 3rd XV |
| Garstang Blues (2nd XV) | v | Warrington 2nd XV |
| North Manchester | v | Trafford MV 2nd XV |
| Orrell 2nd XV | v | Bolton 2nd XV |
| Vale of Lune 3rd XV | v | Preston Grasshoppers 4th XV |
| Saturday, 21 February 2026 |
| Bury 2nd XV | v | Vale of Lune 3rd XV |
| Saturday, 28 February 2026 |
| Altrincham Kersal Cougars (2nd XV) | v | Bury 2nd XV |
| Blackburn RUFC Vikings | v | Warrington 2nd XV |
| Bolton 2nd XV | v | Vale of Lune 3rd XV |
| Eccles 3rd XV | v | Orrell 2nd XV |
| Preston Grasshoppers 4th XV | v | North Manchester |
| Trafford MV 2nd XV | v | Garstang Blues (2nd XV) |
| Saturday, 7 March 2026 |
| Bury 2nd XV | v | Blackburn RUFC Vikings |
| Garstang Blues (2nd XV) | v | Preston Grasshoppers 4th XV |
| North Manchester | v | Bolton 2nd XV |
| Orrell 2nd XV | v | Altrincham Kersal Cougars (2nd XV) |
| Vale of Lune 3rd XV | v | Eccles 3rd XV |
| Warrington 2nd XV | v | Trafford MV 2nd XV |
| Saturday, 21 March 2026 |
| Blackburn RUFC Vikings | v | Trafford MV 2nd XV |
| Bolton 2nd XV | v | Garstang Blues (2nd XV) |
| Bury 2nd XV | v | Orrell 2nd XV |
| Eccles 3rd XV | v | North Manchester |
| Preston Grasshoppers 4th XV | v | Warrington 2nd XV |
| Saturday, 28 March 2026 |
| Garstang Blues (2nd XV) | v | Eccles 3rd XV |
| North Manchester | v | Altrincham Kersal Cougars (2nd XV) |
| Orrell 2nd XV | v | Blackburn RUFC Vikings |
| Trafford MV 2nd XV | v | Preston Grasshoppers 4th XV |
| Vale of Lune 3rd XV | v | Bury 2nd XV |
| Warrington 2nd XV | v | Bolton 2nd XV |
| Saturday, 11 April 2026 |
| Altrincham Kersal Cougars (2nd XV) | v | Garstang Blues (2nd XV) |
| Blackburn RUFC Vikings | v | Preston Grasshoppers 4th XV |
| Bolton 2nd XV | v | Trafford MV 2nd XV |
| Bury 2nd XV | v | North Manchester |
| Eccles 3rd XV | v | Warrington 2nd XV |
| Orrell 2nd XV | v | Vale of Lune 3rd XV |
| Saturday, 18 April 2026 |
| Garstang Blues (2nd XV) | v | Bury 2nd XV |
| North Manchester | v | Orrell 2nd XV |
| Trafford MV 2nd XV | v | Eccles 3rd XV |
| Vale of Lune 3rd XV | v | Blackburn RUFC Vikings |
| Warrington 2nd XV | v | Altrincham Kersal Cougars (2nd XV) |
| Saturday, 25 April 2026 |
| Altrincham Kersal Cougars (2nd XV) | v | Trafford MV 2nd XV |
| Bolton 2nd XV | v | Blackburn RUFC Vikings |
| Bury 2nd XV | v | Warrington 2nd XV |
| Eccles 3rd XV | v | Preston Grasshoppers 4th XV |
| Garstang Blues (2nd XV) | v | Orrell 2nd XV |
| Vale of Lune 3rd XV | v | North Manchester |