| Saturday, 7 September 2024 |
| Buxton RUFC | Abandoned | Knutsford |
| Lymm Eagles | 60 | 40 | Moore |
| Stockport 3rd XV | 7 | 45 | Marple |
| Winnington Park 2nd XV | 75 | 5 | Macclesfield 3rd XV |
| Saturday, 14 September 2024 |
| Macclesfield 3rd XV | v | Lymm Eagles |
| Marple | v | Winnington Park 2nd XV |
| Moore | v | Buxton RUFC |
| Wilmslow 2nd XV | v | Knutsford |
| Saturday, 21 September 2024 |
| Buxton RUFC | v | Macclesfield 3rd XV |
| Knutsford | v | Marple |
| Liverpool Medical School | v | Manchester Medical School 1st XV |
| Lymm Eagles | v | Liverpool University Veterinarians |
| Stockport 3rd XV | v | Moore |
| Winnington Park 2nd XV | v | Wilmslow 2nd XV |
| Saturday, 28 September 2024 |
| Liverpool University Veterinarians | v | Buxton RUFC |
| Macclesfield 3rd XV | v | Stockport 3rd XV |
| Manchester Medical School 1st XV | v | Knutsford |
| Moore | v | Liverpool Medical School |
| Wilmslow 2nd XV | v | Marple |
| Winnington Park 2nd XV | v | Lymm Eagles |
| Saturday, 5 October 2024 |
| Buxton RUFC | v | Manchester Medical School 1st XV |
| Liverpool Medical School | v | Knutsford |
| Liverpool University Veterinarians | v | Wilmslow 2nd XV |
| Saturday, 12 October 2024 |
| Buxton RUFC | v | Winnington Park 2nd XV |
| Knutsford | v | Moore |
| Liverpool Medical School | v | Macclesfield 3rd XV |
| Lymm Eagles | v | Wilmslow 2nd XV |
| Marple | v | Manchester Medical School 1st XV |
| Stockport 3rd XV | v | Liverpool University Veterinarians |
| Saturday, 19 October 2024 |
| Liverpool University Veterinarians | v | Liverpool Medical School |
| Lymm Eagles | v | Buxton RUFC |
| Macclesfield 3rd XV | v | Knutsford |
| Moore | v | Marple |
| Wilmslow 2nd XV | v | Manchester Medical School 1st XV |
| Winnington Park 2nd XV | v | Stockport 3rd XV |
| Saturday, 26 October 2024 |
| Buxton RUFC | v | Wilmslow 2nd XV |
| Knutsford | v | Liverpool University Veterinarians |
| Liverpool Medical School | v | Winnington Park 2nd XV |
| Manchester Medical School 1st XV | v | Moore |
| Marple | v | Macclesfield 3rd XV |
| Stockport 3rd XV | v | Lymm Eagles |
| Saturday, 9 November 2024 |
| Buxton RUFC | v | Stockport 3rd XV |
| Liverpool Medical School | v | Lymm Eagles |
| Liverpool University Veterinarians | v | Marple |
| Macclesfield 3rd XV | v | Manchester Medical School 1st XV |
| Wilmslow 2nd XV | v | Moore |
| Winnington Park 2nd XV | v | Knutsford |
| Saturday, 16 November 2024 |
| Liverpool Medical School | v | Buxton RUFC |
| Lymm Eagles | v | Knutsford |
| Manchester Medical School 1st XV | v | Liverpool University Veterinarians |
| Moore | v | Macclesfield 3rd XV |
| Stockport 3rd XV | v | Wilmslow 2nd XV |
| Saturday, 23 November 2024 |
| Liverpool University Veterinarians | v | Moore |
| Stockport 3rd XV | v | Liverpool Medical School |
| Wilmslow 2nd XV | v | Macclesfield 3rd XV |
| Winnington Park 2nd XV | v | Manchester Medical School 1st XV |
| Saturday, 30 November 2024 |
| Liverpool University Veterinarians | v | Winnington Park 2nd XV |
| Marple | v | Liverpool Medical School |
| Stockport 3rd XV | v | Manchester Medical School 1st XV |
| Saturday, 7 December 2024 |
| Knutsford | v | Stockport 3rd XV |
| Liverpool Medical School | v | Wilmslow 2nd XV |
| Macclesfield 3rd XV | v | Liverpool University Veterinarians |
| Manchester Medical School 1st XV | v | Lymm Eagles |
| Marple | v | Buxton RUFC |
| Moore | v | Winnington Park 2nd XV |
| Saturday, 14 December 2024 |
| Buxton RUFC | v | Moore |
| Knutsford | v | Wilmslow 2nd XV |
| Liverpool Medical School | v | Marple |
| Lymm Eagles | v | Macclesfield 3rd XV |
| Manchester Medical School 1st XV | v | Stockport 3rd XV |
| Winnington Park 2nd XV | v | Liverpool University Veterinarians |
| Saturday, 21 December 2024 |
| Liverpool University Veterinarians | v | Lymm Eagles |
| Macclesfield 3rd XV | v | Buxton RUFC |
| Manchester Medical School 1st XV | v | Liverpool Medical School |
| Marple | v | Knutsford |
| Moore | v | Stockport 3rd XV |
| Wilmslow 2nd XV | v | Winnington Park 2nd XV |
| Saturday, 4 January 2025 |
| Lymm Eagles | v | Marple |
| Saturday, 11 January 2025 |
| Liverpool University Veterinarians | v | Stockport 3rd XV |
| Macclesfield 3rd XV | v | Liverpool Medical School |
| Manchester Medical School 1st XV | v | Marple |
| Moore | v | Knutsford |
| Wilmslow 2nd XV | v | Lymm Eagles |
| Winnington Park 2nd XV | v | Buxton RUFC |
| Saturday, 18 January 2025 |
| Buxton RUFC | v | Lymm Eagles |
| Knutsford | v | Macclesfield 3rd XV |
| Liverpool Medical School | v | Liverpool University Veterinarians |
| Manchester Medical School 1st XV | v | Wilmslow 2nd XV |
| Marple | v | Moore |
| Stockport 3rd XV | v | Winnington Park 2nd XV |
| Saturday, 1 February 2025 |
| Liverpool University Veterinarians | v | Knutsford |
| Lymm Eagles | v | Stockport 3rd XV |
| Macclesfield 3rd XV | v | Marple |
| Moore | v | Manchester Medical School 1st XV |
| Wilmslow 2nd XV | v | Buxton RUFC |
| Winnington Park 2nd XV | v | Liverpool Medical School |
| Saturday, 15 February 2025 |
| Knutsford | v | Winnington Park 2nd XV |
| Lymm Eagles | v | Liverpool Medical School |
| Manchester Medical School 1st XV | v | Macclesfield 3rd XV |
| Marple | v | Liverpool University Veterinarians |
| Moore | v | Wilmslow 2nd XV |
| Stockport 3rd XV | v | Buxton RUFC |
| Saturday, 1 March 2025 |
| Buxton RUFC | v | Liverpool Medical School |
| Knutsford | v | Lymm Eagles |
| Liverpool University Veterinarians | v | Manchester Medical School 1st XV |
| Macclesfield 3rd XV | v | Moore |
| Wilmslow 2nd XV | v | Stockport 3rd XV |
| Winnington Park 2nd XV | v | Marple |
| Saturday, 8 March 2025 |
| Knutsford | v | Buxton RUFC |
| Liverpool Medical School | v | Stockport 3rd XV |
| Macclesfield 3rd XV | v | Wilmslow 2nd XV |
| Manchester Medical School 1st XV | v | Winnington Park 2nd XV |
| Marple | v | Lymm Eagles |
| Moore | v | Liverpool University Veterinarians |
| Saturday, 22 March 2025 |
| Buxton RUFC | v | Marple |
| Liverpool University Veterinarians | v | Macclesfield 3rd XV |
| Lymm Eagles | v | Manchester Medical School 1st XV |
| Stockport 3rd XV | v | Knutsford |
| Wilmslow 2nd XV | v | Liverpool Medical School |
| Winnington Park 2nd XV | v | Moore |
| Saturday, 5 April 2025 |
| Knutsford | v | Liverpool Medical School |
| Macclesfield 3rd XV | v | Winnington Park 2nd XV |
| Manchester Medical School 1st XV | v | Buxton RUFC |
| Marple | v | Stockport 3rd XV |
| Moore | v | Lymm Eagles |
| Wilmslow 2nd XV | v | Liverpool University Veterinarians |
| Saturday, 26 April 2025 |
| Buxton RUFC | v | Liverpool University Veterinarians |
| Knutsford | v | Manchester Medical School 1st XV |
| Liverpool Medical School | v | Moore |
| Lymm Eagles | v | Winnington Park 2nd XV |
| Marple | v | Wilmslow 2nd XV |
| Stockport 3rd XV | v | Macclesfield 3rd XV |