| Saturday, 3 September 2022 |
| Bury 3rd XV | v | Carrington |
| Crewe & Nantwich 3rd XV | v | Eccles 3rd XV |
| Heaton Moor 3rd XV | v | Bolton 4th XV |
| Holmes Chapel 2nd XV | v | Wythenshawe |
| Marple 3rd XV | v | Bowdon 3rd XV |
| Saturday, 10 September 2022 |
| Bolton 4th XV | v | Newcastle (Staffs) 3rd XV |
| Bowdon 3rd XV | v | Holmes Chapel 2nd XV |
| Carrington | v | Manchester Hawks |
| Crewe & Nantwich 3rd XV | v | Bury 3rd XV |
| Eccles 3rd XV | v | Marple 3rd XV |
| Wythenshawe | v | Heaton Moor 3rd XV |
| Saturday, 17 September 2022 |
| Carrington | v | Crewe & Nantwich 3rd XV |
| Heaton Moor 3rd XV | v | Bowdon 3rd XV |
| Holmes Chapel 2nd XV | v | Eccles 3rd XV |
| Manchester Hawks | v | Bolton 4th XV |
| Marple 3rd XV | v | Bury 3rd XV |
| Newcastle (Staffs) 3rd XV | v | Wythenshawe |
| Saturday, 24 September 2022 |
| Bowdon 3rd XV | v | Newcastle (Staffs) 3rd XV |
| Bury 3rd XV | v | Holmes Chapel 2nd XV |
| Carrington | v | Bolton 4th XV |
| Crewe & Nantwich 3rd XV | v | Marple 3rd XV |
| Eccles 3rd XV | v | Heaton Moor 3rd XV |
| Wythenshawe | v | Manchester Hawks |
| Saturday, 1 October 2022 |
| Bolton 4th XV | v | Wythenshawe |
| Carrington | v | Marple 3rd XV |
| Heaton Moor 3rd XV | v | Bury 3rd XV |
| Holmes Chapel 2nd XV | v | Crewe & Nantwich 3rd XV |
| Manchester Hawks | v | Bowdon 3rd XV |
| Newcastle (Staffs) 3rd XV | v | Eccles 3rd XV |
| Saturday, 8 October 2022 |
| Newcastle (Staffs) 3rd XV | v | Manchester Hawks |
| Saturday, 15 October 2022 |
| Bowdon 3rd XV | v | Bolton 4th XV |
| Bury 3rd XV | v | Newcastle (Staffs) 3rd XV |
| Carrington | v | Wythenshawe |
| Crewe & Nantwich 3rd XV | v | Heaton Moor 3rd XV |
| Eccles 3rd XV | v | Manchester Hawks |
| Marple 3rd XV | v | Holmes Chapel 2nd XV |
| Saturday, 22 October 2022 |
| Bolton 4th XV | v | Eccles 3rd XV |
| Heaton Moor 3rd XV | v | Marple 3rd XV |
| Holmes Chapel 2nd XV | v | Carrington |
| Manchester Hawks | v | Bury 3rd XV |
| Newcastle (Staffs) 3rd XV | v | Crewe & Nantwich 3rd XV |
| Wythenshawe | v | Bowdon 3rd XV |
| Saturday, 29 October 2022 |
| Bury 3rd XV | v | Bolton 4th XV |
| Carrington | v | Bowdon 3rd XV |
| Crewe & Nantwich 3rd XV | v | Manchester Hawks |
| Eccles 3rd XV | v | Wythenshawe |
| Holmes Chapel 2nd XV | v | Heaton Moor 3rd XV |
| Marple 3rd XV | v | Newcastle (Staffs) 3rd XV |
| Saturday, 5 November 2022 |
| Bolton 4th XV | v | Crewe & Nantwich 3rd XV |
| Bowdon 3rd XV | v | Eccles 3rd XV |
| Heaton Moor 3rd XV | v | Carrington |
| Manchester Hawks | v | Marple 3rd XV |
| Newcastle (Staffs) 3rd XV | v | Holmes Chapel 2nd XV |
| Wythenshawe | v | Bury 3rd XV |
| Saturday, 12 November 2022 |
| Bury 3rd XV | v | Bowdon 3rd XV |
| Carrington | v | Eccles 3rd XV |
| Crewe & Nantwich 3rd XV | v | Wythenshawe |
| Heaton Moor 3rd XV | v | Newcastle (Staffs) 3rd XV |
| Holmes Chapel 2nd XV | v | Manchester Hawks |
| Marple 3rd XV | v | Bolton 4th XV |
| Saturday, 26 November 2022 |
| Bolton 4th XV | v | Holmes Chapel 2nd XV |
| Bowdon 3rd XV | v | Crewe & Nantwich 3rd XV |
| Eccles 3rd XV | v | Bury 3rd XV |
| Manchester Hawks | v | Heaton Moor 3rd XV |
| Newcastle (Staffs) 3rd XV | v | Carrington |
| Wythenshawe | v | Marple 3rd XV |
| Saturday, 3 December 2022 |
| Bury 3rd XV | v | Crewe & Nantwich 3rd XV |
| Heaton Moor 3rd XV | v | Wythenshawe |
| Holmes Chapel 2nd XV | v | Bowdon 3rd XV |
| Manchester Hawks | v | Carrington |
| Marple 3rd XV | v | Eccles 3rd XV |
| Newcastle (Staffs) 3rd XV | v | Bolton 4th XV |
| Saturday, 10 December 2022 |
| Bolton 4th XV | v | Manchester Hawks |
| Bowdon 3rd XV | v | Heaton Moor 3rd XV |
| Bury 3rd XV | v | Marple 3rd XV |
| Crewe & Nantwich 3rd XV | v | Carrington |
| Eccles 3rd XV | v | Holmes Chapel 2nd XV |
| Wythenshawe | v | Newcastle (Staffs) 3rd XV |
| Saturday, 17 December 2022 |
| Bolton 4th XV | v | Carrington |
| Heaton Moor 3rd XV | v | Eccles 3rd XV |
| Holmes Chapel 2nd XV | v | Bury 3rd XV |
| Manchester Hawks | v | Wythenshawe |
| Marple 3rd XV | v | Crewe & Nantwich 3rd XV |
| Newcastle (Staffs) 3rd XV | v | Bowdon 3rd XV |
| Saturday, 7 January 2023 |
| Bowdon 3rd XV | v | Manchester Hawks |
| Bury 3rd XV | v | Heaton Moor 3rd XV |
| Crewe & Nantwich 3rd XV | v | Holmes Chapel 2nd XV |
| Eccles 3rd XV | v | Newcastle (Staffs) 3rd XV |
| Marple 3rd XV | v | Carrington |
| Wythenshawe | v | Bolton 4th XV |
| Saturday, 14 January 2023 |
| Bolton 4th XV | v | Bowdon 3rd XV |
| Heaton Moor 3rd XV | v | Crewe & Nantwich 3rd XV |
| Holmes Chapel 2nd XV | v | Marple 3rd XV |
| Manchester Hawks | v | Eccles 3rd XV |
| Newcastle (Staffs) 3rd XV | v | Bury 3rd XV |
| Wythenshawe | v | Carrington |
| Saturday, 21 January 2023 |
| Bowdon 3rd XV | v | Wythenshawe |
| Bury 3rd XV | v | Manchester Hawks |
| Carrington | v | Holmes Chapel 2nd XV |
| Crewe & Nantwich 3rd XV | v | Newcastle (Staffs) 3rd XV |
| Eccles 3rd XV | v | Bolton 4th XV |
| Marple 3rd XV | v | Heaton Moor 3rd XV |
| Saturday, 28 January 2023 |
| Bolton 4th XV | v | Bury 3rd XV |
| Bowdon 3rd XV | v | Carrington |
| Heaton Moor 3rd XV | v | Holmes Chapel 2nd XV |
| Manchester Hawks | v | Crewe & Nantwich 3rd XV |
| Newcastle (Staffs) 3rd XV | v | Marple 3rd XV |
| Wythenshawe | v | Eccles 3rd XV |
| Saturday, 11 February 2023 |
| Bury 3rd XV | v | Wythenshawe |
| Carrington | v | Heaton Moor 3rd XV |
| Crewe & Nantwich 3rd XV | v | Bolton 4th XV |
| Eccles 3rd XV | v | Bowdon 3rd XV |
| Holmes Chapel 2nd XV | v | Newcastle (Staffs) 3rd XV |
| Marple 3rd XV | v | Manchester Hawks |
| Saturday, 18 February 2023 |
| Bolton 4th XV | v | Marple 3rd XV |
| Bowdon 3rd XV | v | Bury 3rd XV |
| Eccles 3rd XV | v | Carrington |
| Manchester Hawks | v | Holmes Chapel 2nd XV |
| Newcastle (Staffs) 3rd XV | v | Heaton Moor 3rd XV |
| Wythenshawe | v | Crewe & Nantwich 3rd XV |
| Saturday, 4 March 2023 |
| Bury 3rd XV | v | Eccles 3rd XV |
| Carrington | v | Newcastle (Staffs) 3rd XV |
| Crewe & Nantwich 3rd XV | v | Bowdon 3rd XV |
| Heaton Moor 3rd XV | v | Manchester Hawks |
| Holmes Chapel 2nd XV | v | Bolton 4th XV |
| Marple 3rd XV | v | Wythenshawe |
| Saturday, 11 March 2023 |
| Bolton 4th XV | v | Heaton Moor 3rd XV |
| Bowdon 3rd XV | v | Marple 3rd XV |
| Carrington | v | Bury 3rd XV |
| Eccles 3rd XV | v | Crewe & Nantwich 3rd XV |
| Manchester Hawks | v | Newcastle (Staffs) 3rd XV |
| Wythenshawe | v | Holmes Chapel 2nd XV |