| Saturday, 3 September 2022 |
| Capenhurst | v | Prenton |
| Eagle | v | Oxton Parkonians |
| Newton-le-Willows | v | Moore |
| Oldershaw | v | Crosby St Mary's |
| St Edward's O.B. | v | Mossley Hill |
| Wallasey | v | Christleton |
| Saturday, 10 September 2022 |
| Capenhurst | v | St Edward's O.B. |
| Christleton | v | Newton-le-Willows |
| Moore | v | Mossley Hill |
| Oxton Parkonians | v | Oldershaw |
| Prenton | v | Eagle |
| Wallasey | v | Crosby St Mary's |
| Saturday, 17 September 2022 |
| Eagle | v | Capenhurst |
| Mossley Hill | v | Christleton |
| Newton-le-Willows | v | Crosby St Mary's |
| Oldershaw | v | Prenton |
| St Edward's O.B. | v | Moore |
| Wallasey | v | Oxton Parkonians |
| Saturday, 24 September 2022 |
| Capenhurst | v | Oldershaw |
| Crosby St Mary's | v | Mossley Hill |
| Eagle | v | St Edward's O.B. |
| Moore | v | Christleton |
| Oxton Parkonians | v | Newton-le-Willows |
| Prenton | v | Wallasey |
| Saturday, 1 October 2022 |
| Crosby St Mary's | v | Moore |
| Mossley Hill | v | Oxton Parkonians |
| Newton-le-Willows | v | Prenton |
| Oldershaw | v | Eagle |
| St Edward's O.B. | v | Christleton |
| Wallasey | v | Capenhurst |
| Saturday, 15 October 2022 |
| Capenhurst | v | Newton-le-Willows |
| Crosby St Mary's | v | Christleton |
| Eagle | v | Wallasey |
| Oldershaw | v | St Edward's O.B. |
| Oxton Parkonians | v | Moore |
| Prenton | v | Mossley Hill |
| Saturday, 22 October 2022 |
| Christleton | v | Oxton Parkonians |
| Moore | v | Prenton |
| Mossley Hill | v | Capenhurst |
| Newton-le-Willows | v | Eagle |
| St Edward's O.B. | v | Crosby St Mary's |
| Wallasey | v | Oldershaw |
| Saturday, 29 October 2022 |
| Capenhurst | v | Moore |
| Eagle | v | Mossley Hill |
| Oldershaw | v | Newton-le-Willows |
| Oxton Parkonians | v | Crosby St Mary's |
| Prenton | v | Christleton |
| Wallasey | v | St Edward's O.B. |
| Saturday, 5 November 2022 |
| Christleton | v | Capenhurst |
| Crosby St Mary's | v | Prenton |
| Moore | v | Eagle |
| Mossley Hill | v | Oldershaw |
| Newton-le-Willows | v | Wallasey |
| St Edward's O.B. | v | Oxton Parkonians |
| Saturday, 12 November 2022 |
| Capenhurst | v | Crosby St Mary's |
| Eagle | v | Christleton |
| Newton-le-Willows | v | St Edward's O.B. |
| Oldershaw | v | Moore |
| Prenton | v | Oxton Parkonians |
| Wallasey | v | Mossley Hill |
| Saturday, 26 November 2022 |
| Christleton | v | Oldershaw |
| Crosby St Mary's | v | Eagle |
| Moore | v | Wallasey |
| Mossley Hill | v | Newton-le-Willows |
| Oxton Parkonians | v | Capenhurst |
| St Edward's O.B. | v | Prenton |
| Saturday, 3 December 2022 |
| Crosby St Mary's | v | Wallasey |
| Eagle | v | Prenton |
| Mossley Hill | v | Moore |
| Newton-le-Willows | v | Christleton |
| Oldershaw | v | Oxton Parkonians |
| St Edward's O.B. | v | Capenhurst |
| Saturday, 10 December 2022 |
| Capenhurst | v | Eagle |
| Christleton | v | Mossley Hill |
| Crosby St Mary's | v | Newton-le-Willows |
| Moore | v | St Edward's O.B. |
| Oxton Parkonians | v | Wallasey |
| Prenton | v | Oldershaw |
| Saturday, 17 December 2022 |
| Christleton | v | Moore |
| Mossley Hill | v | Crosby St Mary's |
| Newton-le-Willows | v | Oxton Parkonians |
| Oldershaw | v | Capenhurst |
| St Edward's O.B. | v | Eagle |
| Wallasey | v | Prenton |
| Saturday, 7 January 2023 |
| Capenhurst | v | Wallasey |
| Christleton | v | St Edward's O.B. |
| Eagle | v | Oldershaw |
| Moore | v | Crosby St Mary's |
| Oxton Parkonians | v | Mossley Hill |
| Prenton | v | Newton-le-Willows |
| Saturday, 14 January 2023 |
| Christleton | v | Crosby St Mary's |
| Moore | v | Oxton Parkonians |
| Mossley Hill | v | Prenton |
| Newton-le-Willows | v | Capenhurst |
| St Edward's O.B. | v | Oldershaw |
| Wallasey | v | Eagle |
| Saturday, 21 January 2023 |
| Capenhurst | v | Mossley Hill |
| Crosby St Mary's | v | St Edward's O.B. |
| Eagle | v | Newton-le-Willows |
| Oldershaw | v | Wallasey |
| Oxton Parkonians | v | Christleton |
| Prenton | v | Moore |
| Saturday, 28 January 2023 |
| Christleton | v | Prenton |
| Crosby St Mary's | v | Oxton Parkonians |
| Moore | v | Capenhurst |
| Mossley Hill | v | Eagle |
| Newton-le-Willows | v | Oldershaw |
| St Edward's O.B. | v | Wallasey |
| Saturday, 11 February 2023 |
| Capenhurst | v | Christleton |
| Eagle | v | Moore |
| Oldershaw | v | Mossley Hill |
| Oxton Parkonians | v | St Edward's O.B. |
| Prenton | v | Crosby St Mary's |
| Wallasey | v | Newton-le-Willows |
| Saturday, 18 February 2023 |
| Christleton | v | Eagle |
| Crosby St Mary's | v | Capenhurst |
| Moore | v | Oldershaw |
| Mossley Hill | v | Wallasey |
| Oxton Parkonians | v | Prenton |
| St Edward's O.B. | v | Newton-le-Willows |
| Saturday, 4 March 2023 |
| Capenhurst | v | Oxton Parkonians |
| Eagle | v | Crosby St Mary's |
| Newton-le-Willows | v | Mossley Hill |
| Oldershaw | v | Christleton |
| Prenton | v | St Edward's O.B. |
| Wallasey | v | Moore |
| Saturday, 11 March 2023 |
| Christleton | v | Wallasey |
| Crosby St Mary's | v | Oldershaw |
| Moore | v | Newton-le-Willows |
| Mossley Hill | v | St Edward's O.B. |
| Oxton Parkonians | v | Eagle |
| Prenton | v | Capenhurst |