| Round 1 |
| Saturday, 25 September 2021 |
| 1 | Wallasey | 12 | 24 | Oldershaw |
| 2 | Mossley Hill | v | Bye |
| 3 | Moore | v | Bye |
| 4 | Newton-le-Willows | v | Bye |
| 5 | Helsby | v | Bye |
| 6 | Newcastle (Staffs) 2nd XV | 40 | 19 | Winnington Park 2nd XV |
| 7 | Eagle | v | Bye |
| 8 | Oxton Parkonians | v | Bye |
| 9 | Crosby St Mary's | v | Bye |
| 10 | Port Sunlight | v | Bye |
| 11 | Capenhurst | v | Bye |
| 12 | St Edward's O.B. | v | Bye |
| 13 | Preston Grasshoppers 4th XV | v | Bye |
| 14 | Leek 2nds | v | Bye |
| 15 | Leigh 3rd XV | v | Bye |
| 16 | Blackburn 3rd XV | v | Bye |
| 17 | Lostock | v | Bye |
| 18 | Rochdale 3rd XV | v | Bye |
| 19 | Sedgley Park 4th XV | v | Bye |
| 20 | Blackpool | v | Bye |
| 21 | Lymm Eagles | v | Bye |
| 22 | Fylde Vandals (4th XV) | Home Walkover | Kirkby Lonsdale RUFC Wanderers |
| 23 | Linley & Kidsgrove 1st XV | v | Bye |
| 24 | Oswestry 2nd XV | v | Bye |
| 25 | Ormskirk 2nd XV | v | Bye |
| 26 | Rossendale 3rd XV | v | Bye |
| 27 | Wirral 3rd XV | v | Bye |
| 28 | Northwich 2nd XV | v | Bye |
| 29 | Sandbach 3rd XV | v | Bye |
| 30 | Prenton | v | Bye |
| 31 | Fleetwood 2nd XV | v | Bye |
| 32 | Heaton Moor 2nd XV | v | Bye |
| Round 2 |
| Saturday, 9 October 2021 |
| Oldershaw | 29 | 10 | Mossley Hill |
| Helsby | 22 | 7 | Newcastle (Staffs) 2nd XV |
| Eagle | 101 | 7 | Oxton Parkonians |
| Crosby St Mary's | 10 | 22 | Port Sunlight |
| Capenhurst | Away Walkover | St Edward's O.B. |
| Preston Grasshoppers 4th XV | 26 | 24 | Leek 2nds |
| Leigh 3rd XV | 15 | 14 | Blackburn 3rd XV |
| Lostock | 50 | 7 | Rochdale 3rd XV |
| Sedgley Park 4th XV | Away Walkover | Blackpool |
| Lymm Eagles | 41 | 41 | Fylde Vandals (4th XV) |
| Linley & Kidsgrove 1st XV | 10 | 17 | Oswestry 2nd XV |
| Ormskirk 2nd XV | Home Walkover | Rossendale 3rd XV |
| Wirral 3rd XV | 19 | 0 | Northwich 2nd XV |
| Sandbach 3rd XV | 12 | 7 | Prenton |
| Fleetwood 2nd XV | Home Walkover | Heaton Moor 2nd XV |
| Saturday, 23 October 2021 |
| Moore | 53 | 24 | Newton-le-Willows |
| Round 3 |
| Saturday, 6 November 2021 |
| Helsby | 3 | 34 | Eagle |
| Port Sunlight | Home Walkover | St Edward's O.B. |
| Preston Grasshoppers 4th XV | 10 | 18 | Leigh 3rd XV |
| Fylde Vandals (4th XV) | Home Walkover | Oswestry 2nd XV |
| Ormskirk 2nd XV | 50 | 15 | Wirral 3rd XV |
| Sandbach 3rd XV | Home Walkover | Fleetwood 2nd XV |
| Saturday, 27 November 2021 |
| Oldershaw | 30 | 31 | Moore |
| Lostock | 44 | 17 | Blackpool |
| Round 4 |
| Saturday, 5 February 2022 |
| Moore | 52 | 0 | Port Sunlight |
| Fylde Vandals (4th XV) | 17 | 3 | Leigh 3rd XV |
| Eagle | 19 | 13 | Lostock |
| Ormskirk 2nd XV | 11 | 17 | Sandbach 3rd XV |
| Round 5 |
| Saturday, 26 February 2022 |
| Moore | 66 | 19 | Fylde Vandals (4th XV) |
| Eagle | 41 | 12 | Sandbach 3rd XV |
| Round 6 |
| Saturday, 7 May 2022 |
| Moore | 26 | 25 | Eagle |