| Saturday, 4 September 2021 |
| Burnage 2nd XV | 21 | 62 | Caldy 2nd XV |
| Rossendale 2nd XV | 7 | 27 | Blackburn 2nd XV |
| Sedgley Park 2nd XV | 33 | 40 | Preston Grasshoppers 2nd XV |
| Saturday, 11 September 2021 |
| Blackburn 2nd XV | 15 | 24 | Fylde Hawks (2nd XV) |
| Lymm 2nd XV | 12 | 31 | Rossendale 2nd XV |
| Preston Grasshoppers 2nd XV | 5 | 33 | Caldy 2nd XV |
| Saturday, 18 September 2021 |
| Burnage 2nd XV | 22 | 27 | Preston Grasshoppers 2nd XV |
| Fylde Hawks (2nd XV) | 26 | 22 | Lymm 2nd XV |
| Sandbach 2nd XV | 37 | 25 | Blackburn 2nd XV |
| Saturday, 25 September 2021 |
| Blackburn 2nd XV | 13 | 27 | Chester 2nd XV |
| Lymm 2nd XV | 17 | 48 | Sandbach 2nd XV |
| Saturday, 2 October 2021 |
| Blackburn 2nd XV | 17 | 38 | Sedgley Park 2nd XV |
| Chester 2nd XV | 19 | 22 | Lymm 2nd XV |
| Fylde Hawks (2nd XV) | 57 | 0 | Rossendale 2nd XV |
| Saturday, 9 October 2021 |
| Rossendale 2nd XV | 26 | 45 | Burnage 2nd XV |
| Saturday, 16 October 2021 |
| Blackburn 2nd XV | 24 | 57 | Caldy 2nd XV |
| Fylde Hawks (2nd XV) | 64 | 7 | Burnage 2nd XV |
| Lymm 2nd XV | 18 | 12 | Sedgley Park 2nd XV |
| Rossendale 2nd XV | 17 | 30 | Sandbach 2nd XV |
| Saturday, 23 October 2021 |
| Caldy 2nd XV | 43 | 10 | Lymm 2nd XV |
| Chester 2nd XV | 36 | 10 | Rossendale 2nd XV |
| Preston Grasshoppers 2nd XV | 46 | 0 | Blackburn 2nd XV |
| Saturday, 30 October 2021 |
| Fylde Hawks (2nd XV) | 21 | 17 | Chester 2nd XV |
| Lymm 2nd XV | 55 | 33 | Preston Grasshoppers 2nd XV |
| Rossendale 2nd XV | 22 | 26 | Sedgley Park 2nd XV |
| Sandbach 2nd XV | 67 | 12 | Burnage 2nd XV |
| Saturday, 13 November 2021 |
| Chester 2nd XV | 19 | 15 | Sandbach 2nd XV |
| Sedgley Park 2nd XV | 31 | 27 | Fylde Hawks (2nd XV) |
| Saturday, 20 November 2021 |
| Chester 2nd XV | 92 | 0 | Burnage 2nd XV |
| Fylde Hawks (2nd XV) | 17 | 19 | Caldy 2nd XV |
| Rossendale 2nd XV | Away Walkover | Preston Grasshoppers 2nd XV |
| Sandbach 2nd XV | 14 | 12 | Sedgley Park 2nd XV |
| Saturday, 27 November 2021 |
| Caldy 2nd XV | 53 | 12 | Sandbach 2nd XV |
| Preston Grasshoppers 2nd XV | 45 | 29 | Fylde Hawks (2nd XV) |
| Sedgley Park 2nd XV | 5 | 17 | Chester 2nd XV |
| Saturday, 4 December 2021 |
| Chester 2nd XV | 5 | 12 | Caldy 2nd XV |
| Lymm 2nd XV | Home Walkover | Blackburn 2nd XV |
| Sandbach 2nd XV | 10 | 26 | Preston Grasshoppers 2nd XV |
| Sedgley Park 2nd XV | 59 | 0 | Burnage 2nd XV |
| Saturday, 11 December 2021 |
| Burnage 2nd XV | 14 | 56 | Lymm 2nd XV |
| Preston Grasshoppers 2nd XV | 0 | 27 | Chester 2nd XV |
| Saturday, 8 January 2022 |
| Blackburn 2nd XV | 36 | 27 | Sandbach 2nd XV |
| Lymm 2nd XV | 21 | 12 | Fylde Hawks (2nd XV) |
| Preston Grasshoppers 2nd XV | 53 | 12 | Burnage 2nd XV |
| Saturday, 15 January 2022 |
| Burnage 2nd XV | 69 | 22 | Rossendale 2nd XV |
| Chester 2nd XV | 29 | 14 | Blackburn 2nd XV |
| Sandbach 2nd XV | 14 | 29 | Lymm 2nd XV |
| Saturday, 22 January 2022 |
| Lymm 2nd XV | 5 | 21 | Chester 2nd XV |
| Rossendale 2nd XV | 0 | 56 | Fylde Hawks (2nd XV) |
| Sedgley Park 2nd XV | 7 | 24 | Blackburn 2nd XV |
| Saturday, 29 January 2022 |
| Burnage 2nd XV | 5 | 59 | Fylde Hawks (2nd XV) |
| Caldy 2nd XV | 74 | 13 | Blackburn 2nd XV |
| Saturday, 5 February 2022 |
| Rossendale 2nd XV | 0 | 76 | Caldy 2nd XV |
| Saturday, 12 February 2022 |
| Blackburn 2nd XV | 20 | 19 | Preston Grasshoppers 2nd XV |
| Fylde Hawks (2nd XV) | 20 | 17 | Sandbach 2nd XV |
| Lymm 2nd XV | 17 | 54 | Caldy 2nd XV |
| Rossendale 2nd XV | 0 | 44 | Chester 2nd XV |
| Saturday, 19 February 2022 |
| Burnage 2nd XV | 17 | 16 | Sandbach 2nd XV |
| Chester 2nd XV | 17 | 7 | Fylde Hawks (2nd XV) |
| Preston Grasshoppers 2nd XV | 5 | 5 | Lymm 2nd XV |
| Saturday, 26 February 2022 |
| Sandbach 2nd XV | 38 | 39 | Fylde Hawks (2nd XV) |
| Sedgley Park 2nd XV | 97 | 0 | Rossendale 2nd XV |
| Saturday, 5 March 2022 |
| Blackburn 2nd XV | 10 | 19 | Burnage 2nd XV |
| Caldy 2nd XV | 74 | 12 | Rossendale 2nd XV |
| Fylde Hawks (2nd XV) | 41 | 21 | Sedgley Park 2nd XV |
| Sandbach 2nd XV | 7 | 50 | Chester 2nd XV |
| Saturday, 12 March 2022 |
| Burnage 2nd XV | 34 | 27 | Chester 2nd XV |
| Caldy 2nd XV | 40 | 19 | Fylde Hawks (2nd XV) |
| Preston Grasshoppers 2nd XV | 69 | 7 | Rossendale 2nd XV |
| Sedgley Park 2nd XV | 45 | 5 | Sandbach 2nd XV |
| Saturday, 19 March 2022 |
| Sandbach 2nd XV | Home Walkover | Rossendale 2nd XV |
| Sedgley Park 2nd XV | 21 | 12 | Lymm 2nd XV |
| Saturday, 26 March 2022 |
| Burnage 2nd XV | 50 | 29 | Blackburn 2nd XV |
| Chester 2nd XV | 76 | 7 | Sedgley Park 2nd XV |
| Fylde Hawks (2nd XV) | 26 | 15 | Preston Grasshoppers 2nd XV |
| Sandbach 2nd XV | 0 | 85 | Caldy 2nd XV |
| Saturday, 2 April 2022 |
| Burnage 2nd XV | 35 | 29 | Sedgley Park 2nd XV |
| Caldy 2nd XV | 19 | 12 | Chester 2nd XV |
| Lymm 2nd XV | 20 | 41 | Blackburn 2nd XV |
| Preston Grasshoppers 2nd XV | 23 | 27 | Sandbach 2nd XV |
| Saturday, 9 April 2022 |
| Burnage 2nd XV | 28 | 34 | Lymm 2nd XV |
| Caldy 2nd XV | Home Walkover | Sedgley Park 2nd XV |
| Caldy 2nd XV | Home Walkover | Sedgley Park 2nd XV |
| Chester 2nd XV | 77 | 15 | Preston Grasshoppers 2nd XV |
| Fylde Hawks (2nd XV) | 57 | 27 | Blackburn 2nd XV |
| Saturday, 23 April 2022 |
| Blackburn 2nd XV | 49 | 17 | Rossendale 2nd XV |
| Caldy 2nd XV | 66 | 0 | Burnage 2nd XV |
| Preston Grasshoppers 2nd XV | 20 | 12 | Sedgley Park 2nd XV |
| Saturday, 30 April 2022 |
| Caldy 2nd XV | Home Walkover | Preston Grasshoppers 2nd XV |
| Rossendale 2nd XV | 38 | 5 | Lymm 2nd XV |