| Saturday, 4 September 2021 |
| Moore 2nd XV | Home Walkover | Birkenhead Park 4th XV |
| Winnington Park 3rd XV | 19 | 19 | New Brighton 2nd XV |
| Saturday, 11 September 2021 |
| Ellesmere Port 2nd XV | 14 | 7 | Winnington Park 3rd XV |
| Firwood Waterloo 3rd XV | Home Walkover | Northwich 3rd XV |
| New Brighton 2nd XV | 22 | 31 | Moore 2nd XV |
| Saturday, 18 September 2021 |
| Moore 2nd XV | 24 | 29 | Ellesmere Port 2nd XV |
| Northwich 3rd XV | Home Walkover | Widnes 3rd XV |
| Ormskirk 3rd XV | 31 | 17 | Firwood Waterloo 3rd XV |
| Saturday, 25 September 2021 |
| Birkenhead Park 4th XV | 71 | 0 | Northwich 3rd XV |
| Widnes 3rd XV | 20 | 35 | Ormskirk 3rd XV |
| Winnington Park 3rd XV | 33 | 21 | Moore 2nd XV |
| Saturday, 2 October 2021 |
| Northwich 3rd XV | 32 | 20 | New Brighton 2nd XV |
| Ormskirk 3rd XV | 10 | 12 | Birkenhead Park 4th XV |
| Saturday, 16 October 2021 |
| Birkenhead Park 4th XV | Away Walkover | Christleton |
| Ellesmere Port 2nd XV | Home Walkover | Northwich 3rd XV |
| New Brighton 2nd XV | 13 | 38 | Ormskirk 3rd XV |
| Saturday, 23 October 2021 |
| Christleton | 85 | 7 | New Brighton 2nd XV |
| Firwood Waterloo 3rd XV | Home Walkover | Widnes 3rd XV |
| Northwich 3rd XV | 24 | 17 | Winnington Park 3rd XV |
| Ormskirk 3rd XV | 51 | 7 | Ellesmere Port 2nd XV |
| Saturday, 30 October 2021 |
| Ellesmere Port 2nd XV | 32 | 47 | Christleton |
| Moore 2nd XV | 10 | 19 | Northwich 3rd XV |
| Winnington Park 3rd XV | 12 | 24 | Ormskirk 3rd XV |
| Saturday, 6 November 2021 |
| Firwood Waterloo 3rd XV | 19 | 22 | Christleton |
| Saturday, 13 November 2021 |
| Christleton | 29 | 15 | Winnington Park 3rd XV |
| Firwood Waterloo 3rd XV | 12 | 33 | New Brighton 2nd XV |
| Ormskirk 3rd XV | 81 | 0 | Moore 2nd XV |
| Saturday, 20 November 2021 |
| Christleton | 73 | 10 | Moore 2nd XV |
| Ellesmere Port 2nd XV | Home Walkover | Firwood Waterloo 3rd XV |
| New Brighton 2nd XV | 33 | 22 | Widnes 3rd XV |
| Saturday, 27 November 2021 |
| Widnes 3rd XV | 5 | 37 | Ellesmere Port 2nd XV |
| Saturday, 4 December 2021 |
| Ellesmere Port 2nd XV | 5 | 10 | Birkenhead Park 4th XV |
| Moore 2nd XV | Home Walkover | Firwood Waterloo 3rd XV |
| Northwich 3rd XV | 53 | 17 | Ormskirk 3rd XV |
| Winnington Park 3rd XV | 26 | 0 | Widnes 3rd XV |
| Saturday, 11 December 2021 |
| Birkenhead Park 4th XV | 46 | 26 | Winnington Park 3rd XV |
| New Brighton 2nd XV | 3 | 17 | Ellesmere Port 2nd XV |
| Widnes 3rd XV | 49 | 26 | Moore 2nd XV |
| Saturday, 8 January 2022 |
| Firwood Waterloo 3rd XV | 10 | 21 | Ormskirk 3rd XV |
| Northwich 3rd XV | 5 | 0 | Widnes 3rd XV |
| Saturday, 15 January 2022 |
| Christleton | 45 | 7 | Firwood Waterloo 3rd XV |
| Moore 2nd XV | 20 | 12 | Winnington Park 3rd XV |
| Northwich 3rd XV | 40 | 28 | Birkenhead Park 4th XV |
| Ormskirk 3rd XV | 32 | 21 | Widnes 3rd XV |
| Saturday, 22 January 2022 |
| Birkenhead Park 4th XV | 24 | 29 | Ormskirk 3rd XV |
| New Brighton 2nd XV | 7 | 36 | Northwich 3rd XV |
| Widnes 3rd XV | 27 | 24 | Christleton |
| Saturday, 29 January 2022 |
| Christleton | 43 | 5 | Birkenhead Park 4th XV |
| Ellesmere Port 2nd XV | Home Walkover | Northwich 3rd XV |
| Ormskirk 3rd XV | Home Walkover | New Brighton 2nd XV |
| Saturday, 5 February 2022 |
| Birkenhead Park 4th XV | 30 | 12 | Firwood Waterloo 3rd XV |
| Christleton | 19 | 5 | Widnes 3rd XV |
| Saturday, 12 February 2022 |
| Ellesmere Port 2nd XV | 12 | 21 | Ormskirk 3rd XV |
| Firwood Waterloo 3rd XV | 17 | 19 | Widnes 3rd XV |
| New Brighton 2nd XV | Away Walkover | Christleton |
| Winnington Park 3rd XV | 5 | 25 | Northwich 3rd XV |
| Saturday, 19 February 2022 |
| Christleton | 5 | 0 | Ellesmere Port 2nd XV |
| Firwood Waterloo 3rd XV | 15 | 48 | Birkenhead Park 4th XV |
| Northwich 3rd XV | 43 | 7 | Moore 2nd XV |
| Ormskirk 3rd XV | Home Walkover | Winnington Park 3rd XV |
| Saturday, 26 February 2022 |
| Widnes 3rd XV | 19 | 19 | Birkenhead Park 4th XV |
| Saturday, 5 March 2022 |
| Birkenhead Park 4th XV | 0 | 5 | Widnes 3rd XV |
| Moore 2nd XV | 21 | 52 | Ormskirk 3rd XV |
| New Brighton 2nd XV | Home Walkover | Firwood Waterloo 3rd XV |
| Winnington Park 3rd XV | 3 | 70 | Christleton |
| Saturday, 12 March 2022 |
| Ellesmere Port 2nd XV | 51 | 12 | Firwood Waterloo 3rd XV |
| Moore 2nd XV | Away Walkover | Christleton |
| Widnes 3rd XV | 31 | 7 | New Brighton 2nd XV |
| Saturday, 19 March 2022 |
| Christleton | 48 | 38 | Northwich 3rd XV |
| Ellesmere Port 2nd XV | 10 | 25 | Moore 2nd XV |
| Firwood Waterloo 3rd XV | 44 | 7 | Winnington Park 3rd XV |
| Saturday, 26 March 2022 |
| Birkenhead Park 4th XV | 5 | 0 | New Brighton 2nd XV |
| Ellesmere Port 2nd XV | 21 | 43 | Widnes 3rd XV |
| New Brighton 2nd XV | Away Walkover | Birkenhead Park 4th XV |
| Ormskirk 3rd XV | 10 | 38 | Christleton |
| Winnington Park 3rd XV | 27 | 19 | Firwood Waterloo 3rd XV |
| Saturday, 2 April 2022 |
| Birkenhead Park 4th XV | 10 | 10 | Ellesmere Port 2nd XV |
| Moore 2nd XV | 22 | 37 | Firwood Waterloo 3rd XV |
| Ormskirk 3rd XV | 54 | 5 | Northwich 3rd XV |
| Widnes 3rd XV | Home Walkover | Winnington Park 3rd XV |
| Saturday, 9 April 2022 |
| Ellesmere Port 2nd XV | 5 | 0 | New Brighton 2nd XV |
| Moore 2nd XV | 15 | 50 | Widnes 3rd XV |
| Northwich 3rd XV | 5 | 43 | Christleton |
| Winnington Park 3rd XV | Home Walkover | Birkenhead Park 4th XV |
| Saturday, 23 April 2022 |
| Christleton | 60 | 27 | Ormskirk 3rd XV |
| Moore 2nd XV | 29 | 41 | Birkenhead Park 4th XV |
| New Brighton 2nd XV | Home Walkover | Winnington Park 3rd XV |
| Saturday, 30 April 2022 |
| Firwood Waterloo 3rd XV | 41 | 10 | Northwich 3rd XV |
| Moore 2nd XV | 54 | 19 | New Brighton 2nd XV |
| Winnington Park 3rd XV | 0 | 61 | Ellesmere Port 2nd XV |