| Saturday, 23 January 2021 |
| Glossop 2nd XV | Postponed | Burnage 2nd XV |
| Manchester 2nd XV | Postponed | Broughton Park 2nd XV |
| Manchester Metropolitan University 2nd XV | Postponed | Altrincham Kersal Cougars (2nd XV) |
| Stockport 2nd XV | Postponed | Bowdon 2nd XV |
| Saturday, 30 January 2021 |
| Bowdon 2nd XV | Postponed | Altrincham Kersal Cougars (2nd XV) |
| Broughton Park 2nd XV | Postponed | Stockport 2nd XV |
| Burnage 2nd XV | Postponed | Manchester 2nd XV |
| Glossop 2nd XV | Postponed | Manchester Metropolitan University 2nd XV |
| Saturday, 6 February 2021 |
| Altrincham Kersal Cougars (2nd XV) | Postponed | Stockport 2nd XV |
| Bowdon 2nd XV | Postponed | Manchester 2nd XV |
| Broughton Park 2nd XV | Postponed | Glossop 2nd XV |
| Manchester Metropolitan University 2nd XV | Postponed | Burnage 2nd XV |
| Saturday, 13 February 2021 |
| Altrincham Kersal Cougars (2nd XV) | Postponed | Broughton Park 2nd XV |
| Manchester 2nd XV | Postponed | Glossop 2nd XV |
| Manchester Metropolitan University 2nd XV | Postponed | Bowdon 2nd XV |
| Stockport 2nd XV | Postponed | Burnage 2nd XV |
| Saturday, 20 February 2021 |
| Broughton Park 2nd XV | Postponed | Bowdon 2nd XV |
| Burnage 2nd XV | Postponed | Altrincham Kersal Cougars (2nd XV) |
| Glossop 2nd XV | Postponed | Stockport 2nd XV |
| Manchester 2nd XV | Postponed | Manchester Metropolitan University 2nd XV |
| Saturday, 27 February 2021 |
| Altrincham Kersal Cougars (2nd XV) | Postponed | Glossop 2nd XV |
| Bowdon 2nd XV | Postponed | Burnage 2nd XV |
| Manchester Metropolitan University 2nd XV | Postponed | Broughton Park 2nd XV |
| Stockport 2nd XV | Postponed | Manchester 2nd XV |
| Saturday, 6 March 2021 |
| Burnage 2nd XV | Postponed | Broughton Park 2nd XV |
| Glossop 2nd XV | Postponed | Bowdon 2nd XV |
| Manchester 2nd XV | Postponed | Altrincham Kersal Cougars (2nd XV) |
| Stockport 2nd XV | Postponed | Manchester Metropolitan University 2nd XV |
| Saturday, 13 March 2021 |
| Altrincham Kersal Cougars (2nd XV) | v | Manchester Metropolitan University 2nd XV |
| Bowdon 2nd XV | v | Stockport 2nd XV |
| Broughton Park 2nd XV | v | Manchester 2nd XV |
| Burnage 2nd XV | v | Glossop 2nd XV |
| Saturday, 27 March 2021 |
| Altrincham Kersal Cougars (2nd XV) | v | Bowdon 2nd XV |
| Manchester 2nd XV | v | Burnage 2nd XV |
| Manchester Metropolitan University 2nd XV | v | Glossop 2nd XV |
| Stockport 2nd XV | v | Broughton Park 2nd XV |
| Saturday, 10 April 2021 |
| Bowdon 2nd XV | v | Manchester Metropolitan University 2nd XV |
| Broughton Park 2nd XV | v | Altrincham Kersal Cougars (2nd XV) |
| Burnage 2nd XV | v | Stockport 2nd XV |
| Glossop 2nd XV | v | Manchester 2nd XV |
| Saturday, 17 April 2021 |
| Altrincham Kersal Cougars (2nd XV) | v | Burnage 2nd XV |
| Bowdon 2nd XV | v | Broughton Park 2nd XV |
| Manchester Metropolitan University 2nd XV | v | Manchester 2nd XV |
| Stockport 2nd XV | v | Glossop 2nd XV |
| Saturday, 24 April 2021 |
| Broughton Park 2nd XV | v | Manchester Metropolitan University 2nd XV |
| Burnage 2nd XV | v | Bowdon 2nd XV |
| Glossop 2nd XV | v | Altrincham Kersal Cougars (2nd XV) |
| Manchester 2nd XV | v | Stockport 2nd XV |
| Saturday, 8 May 2021 |
| Altrincham Kersal Cougars (2nd XV) | v | Manchester 2nd XV |
| Bowdon 2nd XV | v | Glossop 2nd XV |
| Broughton Park 2nd XV | v | Burnage 2nd XV |
| Manchester Metropolitan University 2nd XV | v | Stockport 2nd XV |
| Saturday, 15 May 2021 |
| Burnage 2nd XV | v | Manchester Metropolitan University 2nd XV |
| Glossop 2nd XV | v | Broughton Park 2nd XV |
| Manchester 2nd XV | v | Bowdon 2nd XV |
| Stockport 2nd XV | v | Altrincham Kersal Cougars (2nd XV) |