| Saturday, 2 September 2017 |
| Leigh 2nd XV | 34 | 0 | Fleetwood 2nd XV |
| Littleborough 2nd XV | 17 | 10 | West Park (St Helens) 2nd XV |
| Penrith A XV | 37 | 14 | Eccles 2nd XV |
| Tarleton 2nd XV | 40 | 15 | Southport 2nd XV |
| Saturday, 9 September 2017 |
| Bolton 2nd XV | 11 | 5 | Southport 2nd XV |
| Eccles 2nd XV | 22 | 24 | Tarleton 2nd XV |
| Fleetwood 2nd XV | 20 | 54 | Littleborough 2nd XV |
| Thornton Cleveleys | 50 | 12 | Leigh 2nd XV |
| West Park (St Helens) 2nd XV | 20 | 50 | Penrith A XV |
| Saturday, 16 September 2017 |
| Littleborough 2nd XV | 12 | 41 | Thornton Cleveleys |
| Penrith A XV | 61 | 0 | Fleetwood 2nd XV |
| Southport 2nd XV | 34 | 19 | Eccles 2nd XV |
| Tarleton 2nd XV | 33 | 11 | West Park (St Helens) 2nd XV |
| Vale of Lune 3rd XV | 29 | 56 | Bolton 2nd XV |
| Saturday, 23 September 2017 |
| Bolton 2nd XV | 27 | 17 | Eccles 2nd XV |
| Fleetwood 2nd XV | 19 | 36 | Tarleton 2nd XV |
| Thornton Cleveleys | 50 | 5 | Penrith A XV |
| West Park (St Helens) 2nd XV | 41 | 21 | Southport 2nd XV |
| Saturday, 30 September 2017 |
| Eccles 2nd XV | 5 | 26 | West Park (St Helens) 2nd XV |
| Leigh 2nd XV | 19 | 10 | Vale of Lune 3rd XV |
| Southport 2nd XV | 45 | 19 | Fleetwood 2nd XV |
| Tarleton 2nd XV | 5 | 22 | Thornton Cleveleys |
| Saturday, 7 October 2017 |
| Bolton 2nd XV | 15 | 13 | West Park (St Helens) 2nd XV |
| Fleetwood 2nd XV | 34 | 20 | Eccles 2nd XV |
| Thornton Cleveleys | 52 | 3 | Southport 2nd XV |
| Vale of Lune 3rd XV | 33 | 17 | Littleborough 2nd XV |
| Saturday, 21 October 2017 |
| Eccles 2nd XV | 0 | 55 | Thornton Cleveleys |
| Leigh 2nd XV | 17 | 25 | Bolton 2nd XV |
| Penrith A XV | 26 | 0 | Vale of Lune 3rd XV |
| West Park (St Helens) 2nd XV | 29 | 5 | Fleetwood 2nd XV |
| Saturday, 28 October 2017 |
| Bolton 2nd XV | 5 | 10 | Fleetwood 2nd XV |
| Leigh 2nd XV | 7 | 17 | Littleborough 2nd XV |
| Thornton Cleveleys | 87 | 7 | West Park (St Helens) 2nd XV |
| Vale of Lune 3rd XV | 26 | 30 | Tarleton 2nd XV |
| Saturday, 4 November 2017 |
| Fleetwood 2nd XV | 0 | 58 | Thornton Cleveleys |
| Littleborough 2nd XV | 24 | 15 | Bolton 2nd XV |
| Penrith A XV | 17 | 12 | Leigh 2nd XV |
| Southport 2nd XV | 48 | 17 | Vale of Lune 3rd XV |
| Saturday, 11 November 2017 |
| Bolton 2nd XV | 19 | 31 | Thornton Cleveleys |
| Leigh 2nd XV | 36 | 15 | Tarleton 2nd XV |
| Littleborough 2nd XV | 14 | 22 | Penrith A XV |
| Vale of Lune 3rd XV | 0 | 36 | Eccles 2nd XV |
| Saturday, 25 November 2017 |
| Penrith A XV | 41 | 17 | Bolton 2nd XV |
| Southport 2nd XV | 5 | 12 | Leigh 2nd XV |
| Saturday, 2 December 2017 |
| Leigh 2nd XV | Home Walkover | Eccles 2nd XV |
| Littleborough 2nd XV | Home Walkover | Southport 2nd XV |
| Penrith A XV | 10 | 9 | Tarleton 2nd XV |
| Vale of Lune 3rd XV | 10 | 28 | Fleetwood 2nd XV |
| Saturday, 9 December 2017 |
| Southport 2nd XV | 5 | 13 | Penrith A XV |
| Tarleton 2nd XV | 34 | 24 | Bolton 2nd XV |
| Thornton Cleveleys | Home Walkover | Vale of Lune 3rd XV |
| West Park (St Helens) 2nd XV | 5 | 16 | Leigh 2nd XV |
| Saturday, 16 December 2017 |
| Southport 2nd XV | 41 | 3 | Bolton 2nd XV |
| Tarleton 2nd XV | 12 | 0 | Eccles 2nd XV |
| Saturday, 23 December 2017 |
| Tarleton 2nd XV | 24 | 5 | Littleborough 2nd XV |
| West Park (St Helens) 2nd XV | 52 | 12 | Vale of Lune 3rd XV |
| Saturday, 6 January 2018 |
| Bolton 2nd XV | 66 | 26 | Vale of Lune 3rd XV |
| Eccles 2nd XV | 3 | 17 | Southport 2nd XV |
| Fleetwood 2nd XV | 0 | 66 | Penrith A XV |
| Thornton Cleveleys | 32 | 8 | Littleborough 2nd XV |
| West Park (St Helens) 2nd XV | 50 | 7 | Tarleton 2nd XV |
| Saturday, 13 January 2018 |
| Eccles 2nd XV | 17 | 37 | Bolton 2nd XV |
| Penrith A XV | 41 | 19 | Thornton Cleveleys |
| Southport 2nd XV | 17 | 27 | West Park (St Helens) 2nd XV |
| Tarleton 2nd XV | 40 | 19 | Fleetwood 2nd XV |
| Saturday, 20 January 2018 |
| Vale of Lune 3rd XV | 0 | 86 | Leigh 2nd XV |
| West Park (St Helens) 2nd XV | 5 | 29 | Eccles 2nd XV |
| Saturday, 27 January 2018 |
| Eccles 2nd XV | 3 | 36 | Fleetwood 2nd XV |
| Littleborough 2nd XV | 27 | 13 | Vale of Lune 3rd XV |
| Southport 2nd XV | 12 | 52 | Thornton Cleveleys |
| Saturday, 3 February 2018 |
| Bolton 2nd XV | 7 | 10 | Leigh 2nd XV |
| Saturday, 10 February 2018 |
| Penrith A XV | Home Walkover | West Park (St Helens) 2nd XV |
| Thornton Cleveleys | 19 | 27 | Tarleton 2nd XV |
| Saturday, 17 February 2018 |
| Fleetwood 2nd XV | 20 | 59 | Bolton 2nd XV |
| Littleborough 2nd XV | 10 | 12 | Leigh 2nd XV |
| Tarleton 2nd XV | 59 | 7 | Vale of Lune 3rd XV |
| West Park (St Helens) 2nd XV | 22 | 18 | Thornton Cleveleys |
| Saturday, 24 February 2018 |
| Leigh 2nd XV | 28 | 19 | Thornton Cleveleys |
| Littleborough 2nd XV | Home Walkover | Fleetwood 2nd XV |
| West Park (St Helens) 2nd XV | 55 | 12 | Bolton 2nd XV |
| Saturday, 10 March 2018 |
| Eccles 2nd XV | 5 | 85 | Vale of Lune 3rd XV |
| Penrith A XV | 71 | 7 | Littleborough 2nd XV |
| Thornton Cleveleys | 76 | 0 | Bolton 2nd XV |
| Saturday, 17 March 2018 |
| Bolton 2nd XV | 15 | 15 | Littleborough 2nd XV |
| Fleetwood 2nd XV | 34 | 45 | Southport 2nd XV |
| Thornton Cleveleys | Home Walkover | Eccles 2nd XV |
| Vale of Lune 3rd XV | 10 | 74 | Penrith A XV |
| Saturday, 24 March 2018 |
| Bolton 2nd XV | 0 | 34 | Penrith A XV |
| Leigh 2nd XV | 10 | 15 | Southport 2nd XV |
| Littleborough 2nd XV | 36 | 26 | Tarleton 2nd XV |
| Thornton Cleveleys | 68 | 5 | Fleetwood 2nd XV |
| Vale of Lune 3rd XV | 17 | 44 | West Park (St Helens) 2nd XV |
| Saturday, 31 March 2018 |
| Fleetwood 2nd XV | 69 | 12 | West Park (St Helens) 2nd XV |
| Leigh 2nd XV | 48 | 12 | Penrith A XV |
| Vale of Lune 3rd XV | 10 | 17 | Southport 2nd XV |
| Saturday, 7 April 2018 |
| Fleetwood 2nd XV | 30 | 24 | Vale of Lune 3rd XV |
| Leigh 2nd XV | 24 | 12 | Eccles 2nd XV |
| Littleborough 2nd XV | 27 | 31 | Southport 2nd XV |
| Tarleton 2nd XV | 5 | 5 | Penrith A XV |
| Saturday, 14 April 2018 |
| Bolton 2nd XV | 22 | 15 | Tarleton 2nd XV |
| Leigh 2nd XV | 10 | 40 | West Park (St Helens) 2nd XV |
| Littleborough 2nd XV | 41 | 0 | Eccles 2nd XV |
| Penrith A XV | 52 | 26 | Southport 2nd XV |
| Thornton Cleveleys | 67 | 12 | Vale of Lune 3rd XV |
| Saturday, 21 April 2018 |
| Eccles 2nd XV | 14 | 66 | Penrith A XV |
| Fleetwood 2nd XV | 0 | 36 | Leigh 2nd XV |
| Southport 2nd XV | 29 | 17 | Tarleton 2nd XV |
| West Park (St Helens) 2nd XV | 42 | 24 | Littleborough 2nd XV |
| Saturday, 28 April 2018 |
| Eccles 2nd XV | 24 | 26 | Littleborough 2nd XV |
| Tarleton 2nd XV | 19 | 19 | Leigh 2nd XV |