| Saturday, 2 September 2017 |
| Caldy 2nd XV | 23 | 43 | Chester 2nd XV |
| Sedgley Park 2nd XV | 41 | 22 | Macclesfield 2nd XV |
| Saturday, 9 September 2017 |
| Caldy 2nd XV | 25 | 17 | Fylde Wanderers (2nd XV) |
| Chester 2nd XV | 45 | 19 | Sedgley Park 2nd XV |
| Macclesfield 2nd XV | 12 | 15 | Preston Grasshoppers 2nd XV |
| Saturday, 16 September 2017 |
| Chester 2nd XV | 71 | 15 | Macclesfield 2nd XV |
| Preston Grasshoppers 2nd XV | 40 | 33 | Fylde Wanderers (2nd XV) |
| Saturday, 23 September 2017 |
| Fylde Wanderers (2nd XV) | 7 | 95 | Chester 2nd XV |
| Macclesfield 2nd XV | 24 | 54 | Caldy 2nd XV |
| Saturday, 30 September 2017 |
| Preston Grasshoppers 2nd XV | 21 | 52 | Caldy 2nd XV |
| Sedgley Park 2nd XV | 33 | 17 | Fylde Wanderers (2nd XV) |
| Saturday, 7 October 2017 |
| Caldy 2nd XV | 77 | 0 | Sedgley Park 2nd XV |
| Chester 2nd XV | 32 | 5 | Preston Grasshoppers 2nd XV |
| Saturday, 21 October 2017 |
| Macclesfield 2nd XV | 20 | 7 | Fylde Wanderers (2nd XV) |
| Preston Grasshoppers 2nd XV | 33 | 12 | Sedgley Park 2nd XV |
| Saturday, 28 October 2017 |
| Caldy 2nd XV | 45 | 7 | Fylde Wanderers (2nd XV) |
| Preston Grasshoppers 2nd XV | 7 | 38 | Macclesfield 2nd XV |
| Sedgley Park 2nd XV | 7 | 46 | Chester 2nd XV |
| Saturday, 4 November 2017 |
| Chester 2nd XV | 8 | 13 | Caldy 2nd XV |
| Macclesfield 2nd XV | 26 | 10 | Sedgley Park 2nd XV |
| Saturday, 11 November 2017 |
| Caldy 2nd XV | 67 | 24 | Macclesfield 2nd XV |
| Chester 2nd XV | 57 | 5 | Fylde Wanderers (2nd XV) |
| Saturday, 18 November 2017 |
| Fylde Wanderers (2nd XV) | 19 | 5 | Preston Grasshoppers 2nd XV |
| Macclesfield 2nd XV | 21 | 22 | Chester 2nd XV |
| Saturday, 25 November 2017 |
| Fylde Wanderers (2nd XV) | 10 | 29 | Macclesfield 2nd XV |
| Sedgley Park 2nd XV | 24 | 24 | Preston Grasshoppers 2nd XV |
| Saturday, 2 December 2017 |
| Preston Grasshoppers 2nd XV | 11 | 51 | Chester 2nd XV |
| Sedgley Park 2nd XV | 15 | 40 | Caldy 2nd XV |
| Saturday, 9 December 2017 |
| Caldy 2nd XV | 29 | 19 | Preston Grasshoppers 2nd XV |
| Fylde Wanderers (2nd XV) | 5 | 43 | Sedgley Park 2nd XV |
| Saturday, 16 December 2017 |
| Caldy 2nd XV | 29 | 47 | Chester 2nd XV |
| Saturday, 23 December 2017 |
| Fylde Wanderers (2nd XV) | 17 | 17 | Caldy 2nd XV |
| Saturday, 6 January 2018 |
| Chester 2nd XV | 19 | 12 | Sedgley Park 2nd XV |
| Macclesfield 2nd XV | 26 | 28 | Preston Grasshoppers 2nd XV |
| Saturday, 13 January 2018 |
| Chester 2nd XV | 21 | 17 | Macclesfield 2nd XV |
| Preston Grasshoppers 2nd XV | 24 | 38 | Fylde Wanderers (2nd XV) |
| Saturday, 20 January 2018 |
| Fylde Wanderers (2nd XV) | 24 | 43 | Chester 2nd XV |
| Macclesfield 2nd XV | 17 | 5 | Caldy 2nd XV |
| Saturday, 27 January 2018 |
| Preston Grasshoppers 2nd XV | 10 | 22 | Caldy 2nd XV |
| Sedgley Park 2nd XV | 74 | 0 | Fylde Wanderers (2nd XV) |
| Saturday, 3 February 2018 |
| Caldy 2nd XV | 28 | 20 | Sedgley Park 2nd XV |
| Chester 2nd XV | 27 | 7 | Preston Grasshoppers 2nd XV |
| Saturday, 17 February 2018 |
| Macclesfield 2nd XV | 21 | 22 | Fylde Wanderers (2nd XV) |
| Saturday, 24 February 2018 |
| Fylde Wanderers (2nd XV) | 31 | 19 | Caldy 2nd XV |
| Preston Grasshoppers 2nd XV | 19 | 42 | Macclesfield 2nd XV |
| Sedgley Park 2nd XV | 47 | 19 | Chester 2nd XV |
| Saturday, 3 March 2018 |
| Macclesfield 2nd XV | 5 | 0 | Sedgley Park 2nd XV |
| Saturday, 10 March 2018 |
| Caldy 2nd XV | 53 | 19 | Macclesfield 2nd XV |
| Chester 2nd XV | 29 | 0 | Fylde Wanderers (2nd XV) |
| Saturday, 17 March 2018 |
| Chester 2nd XV | 52 | 30 | Caldy 2nd XV |
| Saturday, 24 March 2018 |
| Fylde Wanderers (2nd XV) | 7 | 50 | Preston Grasshoppers 2nd XV |
| Macclesfield 2nd XV | 10 | 13 | Chester 2nd XV |
| Saturday, 31 March 2018 |
| Sedgley Park 2nd XV | 15 | 30 | Macclesfield 2nd XV |
| Saturday, 7 April 2018 |
| Fylde Wanderers (2nd XV) | 15 | 17 | Macclesfield 2nd XV |
| Sedgley Park 2nd XV | 41 | 24 | Preston Grasshoppers 2nd XV |
| Saturday, 14 April 2018 |
| Preston Grasshoppers 2nd XV | 36 | 73 | Chester 2nd XV |
| Sedgley Park 2nd XV | 43 | 24 | Caldy 2nd XV |
| Saturday, 21 April 2018 |
| Caldy 2nd XV | 60 | 35 | Preston Grasshoppers 2nd XV |
| Fylde Wanderers (2nd XV) | 26 | 36 | Sedgley Park 2nd XV |
| Saturday, 28 April 2018 |
| Preston Grasshoppers 2nd XV | 45 | 41 | Sedgley Park 2nd XV |