| Saturday, 23 January 2021 |
| Preston Grasshoppers 2nd XV | Postponed | Blackburn 2nd XV |
| Vale of Lune 2nd XV | Postponed | Rossendale 2nd XV |
| Saturday, 30 January 2021 |
| Blackburn 2nd XV | Postponed | Vale of Lune 2nd XV |
| Rossendale 2nd XV | Postponed | Preston Grasshoppers 2nd XV |
| Saturday, 13 February 2021 |
| Rossendale 2nd XV | Postponed | Blackburn 2nd XV |
| Vale of Lune 2nd XV | Postponed | Preston Grasshoppers 2nd XV |
| Saturday, 13 March 2021 |
| Blackburn 2nd XV | v | Rossendale 2nd XV |
| Preston Grasshoppers 2nd XV | v | Vale of Lune 2nd XV |
| Saturday, 20 March 2021 |
| Blackburn 2nd XV | v | Preston Grasshoppers 2nd XV |
| Rossendale 2nd XV | v | Vale of Lune 2nd XV |
| Saturday, 27 March 2021 |
| Preston Grasshoppers 2nd XV | v | Rossendale 2nd XV |
| Vale of Lune 2nd XV | v | Blackburn 2nd XV |
| Saturday, 10 April 2021 |
| Blackburn 2nd XV | v | Vale of Lune 2nd XV |
| Preston Grasshoppers 2nd XV | v | Rossendale 2nd XV |
| Saturday, 17 April 2021 |
| Rossendale 2nd XV | v | Blackburn 2nd XV |
| Vale of Lune 2nd XV | v | Preston Grasshoppers 2nd XV |
| Saturday, 24 April 2021 |
| Preston Grasshoppers 2nd XV | v | Blackburn 2nd XV |
| Vale of Lune 2nd XV | v | Rossendale 2nd XV |